Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium [PDF]
, 2012 Aims Orthostatic hypotension (OH), an independent predictor of mortality and cardiovascular events, strongly correlates with hypertension. Recent genome-wide studies have identified new loci influencing blood pressure (BP) in populations, but their ...
Almgren, P. (Peter) +22 more
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Coronary artery disease-associated genetic variants and biomarkers of inflammation [PDF]
, 2017 Introduction: Genetic constitution and inflammation both contribute to development of coronary artery disease (CAD). Several CAD-associated single-nucleotide polymorphisms (SNPs) have recently been identified, but their functions are largely unknown.
Ajjan, R +9 more
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Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy. [PDF]
, 2019 Soluble guanylate cyclase (sGC) is the primary receptor for nitric oxide (NO) in mammalian nitric oxide signaling. We determined structures of full-length Manduca sexta sGC in both inactive and active states using cryo-electron microscopy. NO and the sGC-
Hammel, Michal +6 more
core
Efficient algorithms to discover alterations with complementary functional association in cancer
, 2018 Recent large cancer studies have measured somatic alterations in an unprecedented number of tumours. These large datasets allow the identification of cancer-related sets of genetic alterations by identifying relevant combinatorial patterns.
Basso, Rebecca Sarto +2 more
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Moyamoya disease and syndromes: from genetics to clinical management
The Application of Clinical Genetics, 2015 Stéphanie Guey,1,3 Elisabeth Tournier-Lasserve,1,2 Dominique Hervé,1,3 Manoelle Kossorotoff4 1Inserm UMR-S1161, Université Paris 7 Denis Diderot, Sorbonne Paris Cité, Paris, France; 2AP-HP, Groupe hospitalier Lariboisiè ...
Guey S +3 more
doaj
Differential gene expression profile of retinoblastoma compared to normal retina. [PDF]
, 2010 PURPOSE: The retinoblastoma gene (RB1) is a tumor suppressor gene that was first discovered in a rare ocular pediatric tumor called retinoblastoma (RB).
Ganguly, Arupa, Shields, Carol L
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In Systemic Sclerosis, a Unique Long Non Coding RNA Regulates Genes and Pathways Involved in the Three Main Features of the Disease (Vasculopathy, Fibrosis and Autoimmunity) and in Carcinogenesis [PDF]
, 2019 Systemic sclerosis (SSc) is an autoimmune disease characterized by three main features: vasculopathy, immune system dysregulation and fibrosis. Long non-coding RNAs (lncRNAs) may play a role in the pathogenesis of autoimmune diseases and a comprehensive ...
Dolcino, Marzia +3 more
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Fibroblasts profiling in scarring trachoma identifies IL-6 as a functional component of a fibroblast-macrophage pro-fibrotic and pro-inflammatory feedback loop [PDF]
, 2016 Trachoma is a conjunctiva scarring disease, which is the leading infectious cause of blindness worldwide. Yet, the molecular mechanisms underlying progressive fibrosis in trachoma are unknown. To investigate the contribution of local resident fibroblasts
Bailly, M +3 more
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Der Einfluss häufiger genetischer Varianten im KHK-Risikogen GUCY1A3 auf die Thrombozytenfunktion
, 2019 In genomweiten Assoziationsstudien konnte ein Locus auf Chromosom 4q32.1 genomweit signifikant mit der koronaren Herzerkrankung (KHK) assoziiert werden. Der Locus enthält das GUCY1A3-Gen, welches für die alpha1-Untereinheit der löslichen Guanylatzyklase (sGC) kodiert. Die sGC führt Stickstoffmonoxid- (NO-) abhängig durch die Bildung des intrazellulären
openaire +1 more source
A comprehensive analysis of gene expression profiles in distal parts of the mouse renal tubule [PDF]
, 2018 The distal parts of the renal tubule play a critical role in maintaining homeostasis of extracellular fluids. In this review, we present an in-depth analysis of microarray-based gene expression profiles available for microdissected mouse distal nephron ...
Bonny, Olivier +4 more
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