Results 1 to 10 of about 106 (74)

Hypertension reduces soluble guanylyl cyclase expression in the mouse aorta via the Notch signaling pathway

Scientific Reports, 2017
Hypertension is a dominating risk factor for cardiovascular disease. To characterize the genomic response to hypertension, we administered vehicle or angiotensin II to mice and performed gene expression analyses.
Catarina Rippe, Baoyi Zhu, Katarzyna K. Krawczyk, Ed. Van Bavel, Sebastian Albinsson, Jonas Sjölund, Erik N. T. P. Bakker, Karl Swärd   +7 more
doaj   +3 more sources

Identification of target genes and pathways regulated by miRNA-132, miRNA-182, and miRNA-124 in depression: a bioinformatics analysis

Khyber Medical University Journal
OBJECTIVE: To investigate the associations of miRNA-132, miRNA-182, and miRNA-124 with long-term depression and elucidate their target genes and translational implications utilizing miRabel, a bioinformatics tool.
Shamaila Wadud, Sadia Fatima, Roshan Ali, Rubina Nazli, Zahid Khan, Muhammad Irfan   +5 more
doaj   +4 more sources

Complex control of GABA(A) receptor subunit mRNA expression: variation, covariation, and genetic regulation. [PDF]

PLoS ONE, 2012
GABA type-A receptors are essential for fast inhibitory neurotransmission and are critical in brain function. Surprisingly, expression of receptor subunits is highly variable among individuals, but the cause and impact of this fluctuation remains unknown.
Megan K Mulligan, Xusheng Wang, Adrienne L Adler, Khyobeni Mozhui, Lu Lu, Robert W Williams   +5 more
doaj   +4 more sources

Exploring the molecular mechanism of comorbidity of autism spectrum disorder and inflammatory bowel disease by combining multiple data sets

Journal of Translational Medicine, 2023
Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is difficult to diagnose. Inflammatory bowel disease (IBD) is a common chronic digestive disease. Previous studies have shown a potential correlation between ASD and IBD, but
Jinyi Zhu, Haoran Meng, Li Zhang, Yan Li
doaj   +2 more sources

Mechanism of tanshinones and phenolic acids from Danshen in the treatment of coronary heart disease based on co-expression network

BMC Complementary Medicine and Therapies, 2020
Background The tanshinones and phenolic acids in Salvia miltiorrhiza (also named Danshen) have been confirmed for the treatment of coronary heart disease (CHD), but the action mechanisms remain elusive.
Dongxue Wu, Mengqi Huo, Xi Chen, Yanling Zhang, Yanjiang Qiao   +4 more
doaj   +2 more sources

Analyzing and validating the prognostic value and mechanism of colon cancer immune microenvironment

Journal of Translational Medicine, 2020
Background Colon cancer is a disease with high malignancy and incidence in the world. Tumor immune microenvironment (TIM) and tumor mutational burden (TMB) have been proved to play crucial roles in predicting clinical outcomes and therapeutic efficacy ...
Xinyi Wang, Jinzhong Duanmu, Xiaorui Fu, Taiyuan Li, Qunguang Jiang   +4 more
doaj   +2 more sources

ICF, an immunodeficiency syndrome: DNA methyltransferase 3B involvement, chromosome anomalies, and gene dysregulation

Autoimmunity, 2008
The immunodeficiency, centromeric region instability, and facial anomalies syndrome (ICF) is the only disease known to result from a mutated DNA methyltransferase gene, namely, DNMT3B.
Melanie Ehrlich, John H Kehrl, Theo Kurtén   +2 more
exaly   +2 more sources

PRDM16 expression and function in mammalian cochlear development

Developmental Dynamics, Volume 251, Issue 10, Page 1666-1683, October 2022., 2022
Abstract Background PR domain containing 16 (PRDM16) is a key transcriptional regulator in the development of craniofacial, adipose, and neural tissues. Our lab identified PRDM16 expression in the epithelial cells of the Kölliker's organ (KO) that starts at ~E13.5 and is maintained until KO disappearance.
Michael Ebeid, Kathy Barnas, Hongji Zhang, Amal Yaghmour, Gabriele Noreikaite, Bryan C. Bjork   +5 more
wiley   +1 more source

Impact of In Utero Folate Exposure on DNA Methylation and Its Potential Relevance for Later‐Life Health—Evidence from Mouse Models Translated to Human Cohorts

Molecular Nutrition &Food Research, Volume 66, Issue 3, February 2022., 2022
Methylation refers to DNA markers responsible for gene‐activation. It is investigated if methylation changed in response to maternal folate intake during pregnancy. Eight genes have increased (hyper)methylation in fetal and adult mouse liver in response to maternal folate depletion.
Dieuwertje E. Kok, Rebecca C. Richmond, Michiel Adriaens, Chris T. Evelo, Dianne Ford, John C. Mathers, Natassia Robinson, Jill A. McKay   +7 more
wiley   +1 more source

Modulation of vascular contraction via soluble guanylate cyclase signaling in a novel ex vivo method using rat precision‐cut liver slices

Pharmacology Research &Perspectives, Volume 9, Issue 3, June 2021., 2021
Cultures of rat precision cut liver slices (PCLS) were used for ex vivo blood vessel function analysis via live recording. The sGC activator BI703704 differentiates from the sGC stimulator Riociguat in the prevention of serotonin induced blood vessel contraction of normal and fibrotic rat liver slices.
Anouk Oldenburger, Gerald Birk, Marco Schlepütz, Andre Broermann, Birgit Stierstorfer, Steven S. Pullen, Jörg F. Rippmann   +6 more
wiley   +1 more source