Results 11 to 20 of about 106 (74)

FoxO4 Controls sGCβ Transcription in Vascular Smooth Muscle.

American Journal of Physiology. Heart and Circulatory Physiology, 2022
Nitric oxide (NO) binds soluble guanylyl cyclase β (sGCβ) to produce cGMP and relax vascular smooth muscle cells (SMC) needed for vasodilation. While the regulation of NO-stimulated sGC activity has been well-characterized at the post-translational level,
Joseph C. Galley, Megan P. Miller, S. Sanker, Mingjun Liu, I. Sharina, E. Martin, Delphine Gomez, A. Straub   +7 more
semanticscholar   +1 more source

Genome‐wide pathogenesis interpretation using a heat diffusion‐based systems genetics method and implications for gene function annotation

Molecular Genetics &Genomic Medicine, Volume 8, Issue 10, October 2020., 2020
It is still a great challenge to use GWAS/PheWAS‐derived data to elucidate pathogenesis. In this study, we used HotNet2, a heat diffusion‐based systems genetics algorithm, to calculate the networks for disease genes obtained from GWAS and PheWAS, with an attempt to get deeper insights into disease pathogenesis at a molecular level.
Yuan Quan, Qing‐Ye Zhang, Bo‐Min Lv, Rui‐Feng Xu, Hong‐Yu Zhang   +4 more
wiley   +1 more source

Gene Expression, Network Analysis, and Drug Discovery of Neurofibromatosis Type 2‐Associated Vestibular Schwannomas Based on Bioinformatics Analysis

Journal of Oncology, Volume 2020, Issue 1, 2020., 2020
Neurofibromatosis Type 2‐ (NF2‐) associated vestibular schwannomas (VSs) are histologically benign tumors. This study aimed to determine disease‐related genes, pathways, and potential therapeutic drugs associated with NF2‐VSs using the bioinformatics method.
Qiao Huang, Si-Jia Zhai, Xing-Wei Liao, Yu-Chao Liu, Shi-Hua Yin, Pierfrancesco Franco   +5 more
wiley   +1 more source

Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk

Nature, 2011
Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or ≥90 mm Hg diastolic blood pressure).
George B. Ehret, P. Munroe, Andrew D. Johnson, D. Chasman, Albert V Smith, Martin D. Tobin, G. Verwoert, N. Amin, A. Teumer, G. Lucas, Andrew A. Hicks, D. Arking, I. Prokopenko, Paavo, Zitting, Jackie A. Cooper, S. E. Humphries, WiekH. van, Gilst, C. S. Janipalli, K. R. Mani, B. Oostra, A. Demirkan, Aaron Isaacs, F. Rivadeneira, Massimo Mangino, Guangju Zhai, Pankaj Sharma, J. Terzić, E. Lynne, Wagenknecht, F. J. Charchar, Charles N. Rotimi, Fredrik, Nyberg, M. Laan, Kristian Hveem, K. Mohlke, E. Tai, Richard S. Cooper, M. Laakso, T. Harris, RichardW. Morris, M. Kivimaki, Olle Melander, P. Ridker, David Altshuler, Ruth J. F. Loos, A. Shuldiner, Pierre Meneton, A. Uitterlinden, Jacqueline, C. Witteman, Anna-Liisa Hartikainen, Eric, Boerwinkle, Ramachandran S. Vasan, M. Boehnke, G. Martin, Larson, B. Psaty, Aravinda Chakravarti, P. Elliott, C. M. Duijn, C. Newton‐Cheh, Daniel Levy   +65 more
semanticscholar   +1 more source

PSIV-14 Effects of Maternal Nutrient Restriction During Late Gestation on Expelled Cotyledonary Mrna Expression in Primiparous Beef Females

Journal of Animal Science, 2023
To determine the effects of late gestational nutrient restriction on expelled cotyledonary mRNA expression, fall-calving Hereford × Simmental-Angus heifers [single-sired; BW: 451 ± 28 (SD) kg; BCS: 5.4 ± 0.7] bred to a single sire were allocated by ...
C. Redifer, Abigail R Rathert-Williams, Lindsey G Wichman, Allison M Meyer   +3 more
semanticscholar   +1 more source

A genome‐wide association and replication study of blood pressure in Ugandan early adolescents

Molecular Genetics &Genomic Medicine, Volume 7, Issue 10, October 2019., 2019
Using the Entebbe Mother and Baby Study, we aimed to identify genetic variants associated with blood pressure (BP) among Ugandan adolescents. We conducted Genome‐wide association study (GWAS) and replication analysis for variants associated with BP. Variants showing suggestive associations are worthy of future investigation. Replication results suggest
Swaib A. Lule, Alexander J. Mentzer, Benigna Namara, Allan G. Muwenzi, Beatrice Nassanga, Dennison kizito, Helen Akurut, Lawrence Lubyayi, Josephine Tumusiime, Christopher Zziwa, Florence Akello, Deept Gurdasani, Manjinder Sandhu, Liam Smeeth, Alison M. Elliott, Emily L. Webb   +15 more
wiley   +1 more source

Cell-specific deletion of nitric oxide-sensitive guanylyl cyclase reveals a dual pathway for nitrergic neuromuscular transmission in the murine fundus.

Gastroenterology, 2013
BACKGROUND & AIMS It is not clear how nitric oxide (NO) released from enteric neurons relaxes gastrointestinal (GI) smooth muscle. In analogy to the vascular system, NO might directly induce relaxation of smooth muscle cells (SMCs) by acting on its ...
D. Groneberg, B. Lies, P. König, Ronald Jäger, B. Seidler, Sabine Klein, D. Saur, A. Friebe   +7 more
semanticscholar   +1 more source

An integrative systems approach identifies novel candidates in Marfan syndrome‐related pathophysiology

Journal of Cellular and Molecular Medicine, Volume 23, Issue 4, Page 2526-2535, April 2019., 2019
Abstract Marfan syndrome (MFS) is an autosomal dominant genetic disorder caused by mutations in the FBN1 gene. Although many peripheral tissues are affected, aortic complications, such as dilation, dissection and rupture, are the leading causes of MFS‐related mortality.
Raghu Bhushan, Lukas Altinbas, Marten Jäger, Marcin Zaradzki, Daniel Lehmann, Bernd Timmermann, Nicholas P. Clayton, Yunxiang Zhu, Klaus Kallenbach, Georgios Kararigas, Peter N. Robinson   +10 more
wiley   +1 more source

Bufei Qingyu Granules Inhibit the Development of Systemic Sclerosis via Notch‐1/Jagged‐2 Signaling Pathway

Evidence-Based Complementary and Alternative Medicine, Volume 2019, Issue 1, 2019., 2019
Systemic sclerosis (SSc) is a rare chronic autoimmune disorder, mainly characterized by skin sclerosis. In this study, Bufei Qingyu Granules (BQG), a Chinese herbal formula, was used to treat SSc. To better understand the effects and molecular mechanisms of BQG, we successfully established a Bleomycin‐ (BLM‐) induced SSc mouse model, and the mice were ...
Minhui Su, Fang Tian, Bingchen Ouyang, Xiaoyu Wu, Feng Guo, Hua Chen, Xuejun Zhu, Jianmei Chen, Xian Qian, Yuewen Gong   +9 more
wiley   +1 more source

Soluble guanylate cyclase contribute genetic susceptibility to essential hypertension in the Han Chinese population.

Annals of Translational Medicine, 2019
Background Animal study found that soluble guanylate cyclase (sGC) plays an important role in development of hypertension (HT) by affecting the NO-sGC-CGMP signaling pathway. This study aims to evaluate the association of sGC with essential hypertension (
Yan Chen, Lijun Zhu, Z. Fang, Yuelong Jin, Chong Shen, Ying-shui Yao, Chengchao Zhou   +6 more
semanticscholar   +1 more source