Results 21 to 30 of about 1,019 (115)

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. [PDF]

, 2011
Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or  ≥90 mm Hg diastolic blood pressure).
Abecasis GR, Abecasis, Gonçalo R., Absher D, Adair, Linda S., Adeyemo, Adebowale, Aherrahrou Z, Ahmadi KR, Ala-Korpela, Mika, Alexander, Myriam, Altshuler D, Altshuler, David, Amin, Najaf, Andersen K, Aragam J, Arfan Ikram, M., Arking DE, Arking, Dan E., Arnett D, Arora, Pankaj, Artigas, Maria Soler, Aspelund T, Aspelund, Thor, Assimes TL, Atkinson EJ, Aulchenko YS, Aulchenko YS, Aulchenko YS, Aulchenko, Yurii, Badola S, Bakker SJ, Bakker, Stephan J. L., Ball SG, Balmforth AJ, Bandinelli, Stefania, Barbalic M, Barroso, Inês, Beckmann J, Beckmann, Jacques S., Beilby, John P., Benjamin E, Benjamin EJ, Bergman, Richard N., Bergmann, Sven, Bickel C, Bilo HJ, Bis J, Bis JC, Bis JC, Bis, Joshua C., Blankenberg S, Blankenberg S, Blankenberg S, Blettner M, Boban M, Bochud M, Bochud, Murielle, Boehnke, Michael, Boerwinkle E, Boerwinkle E, Boerwinkle E, Boerwinkle, Eric, Bolton, Judith A Hoffman, Bonnycastle, Lori L., Borecki I, Bornstein, Stefan R., Bots, Michiel L., Bragg-Gresham, Jennifer L., Brand, Eva, Brand, Stefan-Martin, Brandstätter A, Braund PS, Braund, Peter S., Brown MJ, Brown, Morris J., Bruse P, Burnett MS, Burton, Paul R., Burtt N, Böger CA, Böhm BO, Cambien F, Campbell H, Campbell S, Campbell, Harry, Casas, Juan P., Caulfield MJ, Caulfield, Mark J., Cavalieri M, Chakravarti, Aravinda, Chambers JC, Chambers, John C., Chandak, Giriraj R., Chang PP, Chang, Yen-Pei C., Charchar, Fadi J., Charlotte Onland-Moret, N., Chasman DI, Chasman, Daniel I., Chaturvedi, Nish, Chen IY, Chen L, Chen, Ming-Huei, Cho, Yoon Shin, Clarke, Robert, Collins, Francis S., Connell JM, Connell, John M., Cook HT, Cook HT, Cooper, Jackie A., Cooper, Matthew N., Cooper, Richard S., Coresh J, Coresh, Josef, Cornelis MC, Corsi, Anna Maria, Cotlarciuc I, Cotlarciuc I, Couper D, Cupples LA, Cupples LA, Curhan GC, Dahgam, Santosh, Dandona S, Danesh, John, Davey Smith G, Davey Smith G, Day, Ian N. M., de Andrade M, de Boer J, de Jong PE, de Silva R, de Silva R, Deckers JW, Dehghan A, Dehghan A, Dehghan A, Dehghan A, Dehghan, Abbas, Deloukas, Panos, Demirkan, Ayse, Demissie S, Demissie-Banjaw S, Deng G, Deng G, Denniff, Matthew, Devaney J, Devuyst O, Devuyst O, Dikkeschei LD, Dikkeschei LD, Dimkovic T, Dobnig H, Dockrell M, Doering A, Dominiczak A, Dominiczak, Anna F., Dong, Yanbin, Doumatey, Ayo, Dreisbach, Albert W., Dörr M, Dörr, Marcus, Ebrahim S, Eggermann T, Ehret, Georg B., Eiriksdottir G, Ellinghaus D, Elliot P, Elliott, Paul, Elosua R, Elosua, Roberto, Emilsson, Valur, Endlich K, Epstein S, Erdmann J, Erdmann J, Erdmann, Jeanette, Eyheramendy, Susana, Farrall M, Farrall, Martin, Fava, Cristiano, Feitosa M, Felix JF, Felix JF, Felix JF, Felix SB, Ferrucci L, Ferrucci L, Ferrucci, Luigi, Fisher M, Floege J, Folsom A, Folsom AR, Forouhi NG, Forrester, Terrence, Fortmann S, Fowkes, F. Gerald R., Fox CS, Fox ER, Fox, Ervin R., Franke A, Frayling, Timothy M., Freyer J, Friedrich N, Fuchsberger C, Gabriel SB, Galan, Pilar, Gale DP, Ganesh, Santhi K., Gansevoort RT, Gao X, Garcia, Melissa, Gaunt, Tom R., Giallauria, Francesco, Gieger, Christian, Glazer N, Glazer NL, Glazer NL, Glazer NL, Glazer, Nicole L., Go A, Go, Min Jin, Goel, Anuj, Gottdiener JS, Gottdiener JS, Grammer TB, Greiser KH, Gretarsdottir S, Grobbee, Diederick E., Groop, Leif, Grosshennig A, Grosshennig A, Grässler, Jürgen, Guarrera, Simonetta, Gudnason V, Gudnason V, Gudnason, Vilmundur, Guiducci C, Gulcher JR, Gulde S, Guo, Xiuqing, Gyllensten U, Gyllensten, Ulf B., Hadley, David, Haerting J, Hakonarson HH, Hall AS, Halperin E, Hamsten, Anders, Han X, Han, Bok-Ghee, Hardy, Rebecca, Haritunians T, Haritunians T, Haritunians T, Harris T, Harris TB, Harris, Tamara B., Hartikainen, Anna-Liisa, Hastie N, Hayward C, Hayward, Caroline, Heath, Simon, Heckbert S, Heckbert SR, Heckbert SR, Heckbert, Susan R., Hedblad B, Hedblad, Bo, Heid IM, Hengstenberg C, Hepkema BG, Hercberg, Serge, Hernandez, Dena, Hernandez-Fuentes M, Hicks, Andrew A., Hilton, Gina, Hingorani, Aroon D., Hlatky M, Hoang Nguyen, Khanh-Dung, Hoffmann M, Hofman A, Hofman A, Hofman A, Hofman A, Hofman, Albert, Holm H, Homan van der Heide JJ, Homuth G, Hopewell, Jemma C., Howard, Philip, Hu FB, Humphries, Steve E., Hunt, Steven C., Hunter Young, J., Hveem, Kristian, Hwang SJ, Hwang, Shih-Jen, Hypponen E, Igl W, Igl, Wilmar, Illig T, Illig T, Imboden M, Ingelsson E, Iribarren C, Isaacs A, Isaacs, Aaron, Islam, Muhammad, Iwai, Naoharu, Jackson, Anne U., Jafar, Tazeen H., Janipalli, Charles S., Jarinova O, Jarvelin MR, Johansson A, Johnson A, Johnson T, Johnson, Andrew D., Johnson, Toby, Järvelin, Marjo-Riitta, Kangas, Antti J., Kao WH, Kao, Wen Hong Linda, Kardia SL, Kardia, Sharon L., Kathiresan S, Kathiresan S, Kathiresan, Sekar, Kedenko L, Kent KM, Ketkar S, Kettunen, Johannes, Khaw, Kay-Tee, Kim, Hyung-Lae, Kinra, Sanjay, Kita, Yoshikuni, Kivimaki, Mika, Kleber M, Kleefstra N, Klopp N, Klopp N, Knouf CW, Knowles J, Koenig W, Kolcic I, Kollerits B, Kong A, Kooner JS., Kooner, Jaspal S., Kovacs P, Kranthi Kumar, M. V., Kroemer HK, Kroemer HK, Kroemer, Heyo K., Kronenberg F, Krämer BK, Kuh, Diana, Kulkarni, Smita R., Kullo I, Kumari, Meena, Kuusisto, Johanna, Kuznetsova, Tatiana, Kähönen, Mika, König IR, König IR, Köttgen A, Köttgen, Anna, Laakso, Markku, Laaksonen R, Laan, Maris, Lackner K, Lackner KJ, Lagou V, Laitinen, Jaana, Lakatta, Edward G., Langefeld, Carl D., Lapsley M, Larson MG, Larson, Martin G., Lathrop, Mark, Launer LJ, Launer, Lenore, Lawlor DA, Lawlor, Debbie A., Lawrence, Robert W., Leak TS, Lee, Jong-Young, Lee, Nanette R., Lehtimäki, Terho, Levy D, Levy D, Levy D, Levy, Daniel, Li M, Li M, Li Y, Li, Yali, Lieb W, Lieb W, Lieb W, Lightstone L, Lind L, Lindsay JM, Linsel-Nitschke P, Liu Y, Liu, Yongmei, Loehr LR, Lohman K, Lohman, Kurt K., Loley C, Longstreth Jr. , W. T., Loos RJ, Loos, Ruth J. F., Lord GM, Luan J, Luan, Jian'an, Lucas, Gavin, Ludwig, Barbara, Lumley T, Lumley T, Lumley T, Lumley T, Luttropp K, Lyytikäinen, Leo-Pekka, Mangino, Massimo, Marciante K, Marmot, Michael G., Maréchal C, Mattace-Raso, Francesco U. S., Mattha W, Matullo, Giuseppe, Maxwell PH, McArdle, Wendy L., McCarthy MI, McKenzie, Colin A., McPherson R, Medack A, Meinitzer A, Meisinger C, Meisinger C, Meitinger T, Meitinger T, Meitinger, Thomas, Melander O, Melander O, Melander, Olle, Meneton, Pierre, Meschia, James F., Metter J, Meyers R, Miki, Tetsuro, Milaneschi, Yuri, Minelli C, Mitchell BD, Mitchell GF, Mohlke, Karen L., Mooser V, Mooser V, Mooser, Vincent, Morken, Mario A., Morris, Richard W., Morrison A, Morrison AC, Morrison, Alanna C., Mosley, Thomas H., Munroe PB, Munroe, Patricia B., Munzel TF, Munzel TF, Murabito J, Musunuru K, Mägi R, März W, Münzel T, Nahrstedt J, Najjar, Samer, Nalls, Michael A., Narisu, Narisu, Nauck M, Navis G, Navis, Gerjan, Nelson C, Newton-Cheh, Christopher, Nicaud V, Nilsson, Peter, Nitsch D, Nordfors L, Nyberg, Fredrik, O'Connell JR, O'Connell, Jeffrey R., O'Donnell CJ, O'Donnell CJ, O'Donnell CJ, O'Donnell, Christopher J., O'Reilly, Paul F., Ogihara, Toshio, Ohkubo, Takayoshi, Okamura, Tomonori, Olden M, Olden, Matthias, Ongen, Halit, Oostra BA, Oostra, Ben A., Org, Elin, Orru, Marco, Palmas, Walter, Palmen, Jutta, Palmer, Lyle J., Palmer, Nicholette D., Parker AN, Parker, Alex N., Parsa A, Parsa A, Parsa, Afshin, Paré G, Pattaro C, Pattaro, Cristian, Paulweber B, Peden, John F., Peltonen L, Peltonen L, Peltonen, Leena, Penninx BW, Perola, Markus, Perret C, Perucha E, Peters A, Pichard AD, Pihur, Vasyl, Pilz S, Platou, Carl G. P., Plump, Andrew, Polasek O, Polasek, Ozren, Pouta A, Prabhakaran, Dorairaj, Pramstaller PP, Pramstaller, Peter P., Preuss M, Probst-Hensch NM, Prokopenko I, Prokopenko I, Prokopenko, Inga, Proust C, Province M, Psaty BM, Psaty BM, Psaty BM, Psaty BM, Psaty, Bruce M., Qu L, Quertermous T, Rader DJ, Radha Mani, K., Raffel, Leslie J., Raitakari, Olli, Ramachandran V, Rampersaud E, Rao, Dabeeru C., Rasheed, Asif, Redfield MM, Reffelmann T, Reilly MP, Renner W, Rettig R, Rettig, Rainer, Ricceri, Fulvio, Rice K, Rice K, Rice KM, Rice, Kenneth M., Ridker PM, Ridker, Paul M., Risch N, Rivadeneira F, Rivadeneira F, Rivadeneira F, Rivadeneira, Fernando, Roberts R, Rochat T, Rodeheffer RJ, Roderick PJ, Rosamond WD, Rosengren, Annika, Rotimi, Charles, Rotter JI, Rotter JI, Rotter JI, Rotter, Jerome I., Rudan I, Rudan, Igor, Rudock, Megan E., Ruokonen A, Rupprecht HJ, Salako, Tunde, Saleheen, Danish, Salomaa V, Salomaa, Veikko, Samani NJ, Samani NJ, Samani, Nilesh J., Sanna S, Satler L, Schalling M, Scharnagl H, Schillert A, Schillert A, Schillert A, Schlessinger D, Schlieper G, Schmidt H, Schmidt H, Schmidt R, Schmidt R, Schnabel R, Schnabel RB, Schnabel RB, Schreiber S, Schreiber S, Schunkert H, Schunkert H, Schwartz SM, Schwartz, Stephen M., Schwarz, Peter E. H., Scott J, Scott, James, Scott, Laura J., Scuteri, Angelo, Seelen MA, Sehmi JS, Sehmi, Joban S., Seielstad, Mark, Seshadri, Sudha, Sharma, Pankaj, Shaw-Hawkins, Sue, Shi, Gang, Shlipak MG, Shrine, Nick R. G., Shriner, Daniel, Shuldiner AR, Shuldiner AR, Shuldiner, Alan R., Shyong Tai, E., Sidney S, Sijbrands, Eric J. G., Sim, Xueling, Singleton A, Singleton, Andrew, Sinning C, Siscovick D, Siscovick DS, Sjögren M, Sjögren, Marketa, Smit JH, Smith A, Smith AV, Smith N, Smith NL, Smith NL, Smith, Albert V., Smith, George Davey, Smith, Nicholas L., Snieder H, Snieder, Harold, Sober, Siim, Soininen, Pasi, Soranzo N, Soranzo, Nicole, Spector TD, Spector, Tim D., Staessen, Jan A., Stančáková, Alena, Stark K, Stefansson K, Steinle, Nanette I., Stenvinkel P, Sternberg MJ, Stewart AF, Stojakovic T, Strachan, David P., Stricker B, Stricker BH, Stringham, Heather M., Stritzke J, Struchalin M, Struchalin M, Stumvoll M, Sun, Yan V., Swaminathan R, Swift, Amy J., Tabara, Yasuharu, Talmud, Philippa J., Tanaka T, Tanaka T, Tanaka, Toshiko, Tang H, Taylor KD, Taylor, Andrew, Tayo, Bamidele, Terzic, Janos, Teumer A, Teumer A, Teumer, Alexander, Thelle, Dag S., Thompson JR, Thorgeirsson G, Thorleifsson G, Thorsteinsdottir U, Tiret L, Tobin, Martin D., Tomaschitz A, Tomaszewski, Maciej, Tripathy, Vikal, Tukiainen, Taru, Tuomilehto, Jaakko, Turne ST, Twee-HeeOng, Rick, Tzoulaki, Ioanna, Tönjes A, Ubink-Veltmaat LJ, Uda M, Uda, Manuela, Ueshima, Hirotsugu, Uiterwaal, Cuno S. P. M., Uitterlinden A, Uitterlinden AG, Uitterlinden AG, Uitterlinden AG, Uitterlinden, Andre G., Umemura, Satoshi, van der Harst P, van der Harst, Pim, van der Schouw, Yvonne T., van Duijn C, van Duijn CM, van Duijn CM, van Duijn CM, van Duijn, Cornelia M., van Gilst, Wiek H., Vartiainen, Erkki, Vasan R, Vasan RS, Vasan, Ramachandran S., Veldre, Gudrun, Verwoert, Germaine C., Viigimaa, Margus, Viikari, Jorma, Vinay, D. G., Vineis, Paolo, Vitart V, Vitart, Veronique, Voight BF, Voight, Benjamin F., Volcik K, Vollenweider P, Vollenweider, Peter, Völker U, Völker U, Völker, Uwe, Völzke H, Völzke H, Völzke, Henry, Waeber G, Wagenknecht, Lynne E., Wain, Louise V., Waksman R, Walker M, Wallace C, Wang TJ, Wang TJ, Wang W, Wang YA, Wang, Thomas J., Wang, Xiaoling, Wareham NJ, Wareham, Nicholas J., Wass MN, Waterworth D, Waterworth DM, Watkins, Hugh, Watzinger N, Weder, Alan B., Wells GA, Werdan K, Whincup, Peter H., Whitteman J, Wichmann HE, Wichmann HE, Wichmann HE, Wichmann, H. -Erich, Wiggins, Kerri L., Wild P, Wild PS, Wild PS, Wild SH, Wild, Sarah H., Wilde S, Wilensky R, Willenborg C, Willerson JT, Wilson JF, Wilson, James F., Winkelmann BR, Winkler K, Witteman JC, Witteman JC, Witteman JC, Witteman, Jacqueline C. M., Wong, Andrew, Wong, Tien Y., Wright AF, Wright BJ, Wright, Alan F., Wu, Ying, Würtz, Peter, Yajnik, Chittaranjan S., Yang Q, Yao, Jie, Zaboli G, Zelenika, Diana, Zeller T, Zeller T, Zeller T, Zemunik T, Zerres K, Zgaga L, Zhai, Guangju, Zhang W, Zhang, Feng, Zhang, Weihua, Zhao, Jing Hua, Zhu, Haidong, Zhu, Xiaofeng, Ziegler A, Ziegler A, Ziegler A, Zillikens MC, Zitting, Paavo, Zukowska-Szczechowska, Ewa, Zweiker R   +840 more
core   +11 more sources

Increasing the Understanding of Nutrient Transport Capacity of the Ovine Placentome. [PDF]

Animals (Basel)
Placental nutrient transport capacity influences fetal growth and development; however, it is affected by environmental factors, which are poorly understood.
Erichsen C, Heiser A, Haack N, Maclean P, Dwyer CM, McCoard S.   +5 more
europepmc   +5 more sources

Genome‐wide pathogenesis interpretation using a heat diffusion‐based systems genetics method and implications for gene function annotation

Molecular Genetics &Genomic Medicine, Volume 8, Issue 10, October 2020., 2020
It is still a great challenge to use GWAS/PheWAS‐derived data to elucidate pathogenesis. In this study, we used HotNet2, a heat diffusion‐based systems genetics algorithm, to calculate the networks for disease genes obtained from GWAS and PheWAS, with an attempt to get deeper insights into disease pathogenesis at a molecular level.
Yuan Quan, Qing‐Ye Zhang, Bo‐Min Lv, Rui‐Feng Xu, Hong‐Yu Zhang   +4 more
wiley   +1 more source

Gene Expression, Network Analysis, and Drug Discovery of Neurofibromatosis Type 2‐Associated Vestibular Schwannomas Based on Bioinformatics Analysis

Journal of Oncology, Volume 2020, Issue 1, 2020., 2020
Neurofibromatosis Type 2‐ (NF2‐) associated vestibular schwannomas (VSs) are histologically benign tumors. This study aimed to determine disease‐related genes, pathways, and potential therapeutic drugs associated with NF2‐VSs using the bioinformatics method.
Qiao Huang, Si-Jia Zhai, Xing-Wei Liao, Yu-Chao Liu, Shi-Hua Yin, Pierfrancesco Franco   +5 more
wiley   +1 more source

Soluble guanylyl cyclase α1 subunit is a key mediator of proliferation, survival, and migration in ECC-1 and HeLa cell lines [PDF]

, 2019
Soluble guanylyl cyclase (sGC) is a heterodimeric enzyme constituted by two subunits, α1 and β1. Previously we have shown that 17β-estradiol (E2) exerts opposite effects on these subunits by increasing α1 and decreasing both β1 expression and enzymatic ...
Bollani, Sabrina Natalia, Cabilla, Jimena Paula, Cordeiro, Georgina, Duvilanski, Beatriz Haydee, Pino, María Teresa Luján, Ricci, Analía Gabriela, Ronchetti, Sonia Alejandra   +6 more
core   +1 more source

Soluble Guanylate Cyclase Generation of cGMP Regulates Migration of MGE Neurons [PDF]

, 2013
Here we have provided evidence that nitric oxide-cyclic GMP (NO-cGMP) signaling regulates neurite length and migration of immature neurons derived from the medial ganglionic eminence (MGE).
Buys, E. S., Enikolopov, G., Mandal, S., Rubenstein, J. L., Stanco, A.   +4 more
core   +1 more source

Profiling age-related epigenetic markers of stomach adenocarcinoma in young and old subjects [PDF]

, 2015
The purpose of our study is to identify epigenetic markers that are differently expressed in the stomach adenocarcinoma (STAD) condition. Based on data from The Cancer Genome Atlas (TCGA), we were able to detect an age-related difference in methylation ...
Bhak, Jong Hwa, Chung, Hae Young, Im, Eunok, Jeong, Hyoung Oh, Kim, Byoung-Chul, Kim, Chul-Hong, Kim, Dae Hyun, Kim, Nam Deuk, Lee, Eun Kyeong, Lee, Sunghoon, Park, Daeui, Yu, Byung Pal   +11 more
core   +2 more sources

Statistical confidence estimation for Hi-C data reveals regulatory chromatin contacts [PDF]

, 2014
Our current understanding of how DNA is packed in the nucleus is most accurate at the fine scale of individual nucleosomes and at the large scale of chromosome territories.
Bailey, Timothy L., Ferhat, Ay, Noble, William Stafford   +2 more
core   +1 more source

Gene expression within the extended amygdala of 5 pairs of rat lines selectively bred for high or low ethanol consumption [PDF]

, 2013
The objectives of this study were to determine innate differences in gene expression in 2 regions of the extended amygdala between 5 different pairs of lines of male rats selectively bred for high or low ethanol consumption: a) alcohol-preferring (P) vs.
Bell, Richard L., Colombo, Giancarlo, Ding, Zheng-Ming, Edenberg, Howard J., Hyytia, Petri, Kimpel, Mark W., Liang, Tiebing, Lumeng, Lawrence, McBride, William J., McClintick, Jeanette N.   +9 more
core   +2 more sources

Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium [PDF]

, 2012
Aims: Orthostatic hypotension (OH), an independent predictor of mortality and cardiovascular events, strongly correlates with hypertension. Recent genome-wide studies have identified new loci influencing blood pressure (BP) in populations, but their ...
Almgren, Peter,, Boerwinkle, Eric, Brody, Jennifer, Couper, David, Fedorowski, Artur,, Franceschini, Nora, Hedblad, Bo,, Hofman, Albert, Larson, Martin G, Levy, Daniel, Liu, Chunyu, Lund University., Lund University., Lund University., Lund University., Lund University., Melander, Olle,, Newton-Cheh, Christopher, Psaty, Bruce M, Raso, Francesco Mattace, Rice, Kenneth M, Rose, Kathryn M, Rotter, Jerome I, Sjögren, Marketa,, Uitterlinden, Andre, Verwoert, Germaine C, Wang, Thomas J, Witteman, Jacqueline   +27 more
core   +7 more sources