Results 21 to 30 of about 106 (74)
Molecular Genetics &Genomic Medicine, Volume 6, Issue 6, Page 1199-1208, November 2018., 2018 NextGen sequencing and analysis of clinically derived Fanconi anemia (FA) cell lines are presented. FA affects only 1 in 130,000 births, but has severe and diverse clinical and genome stability/regulation consequences. We find that the lines have accumulated numerous genetic variants, including high impact mutations, such as deletion of start codons ...
Karthik Raja Velmurugan +4 more
wiley +1 more source
Mediators of Inflammation, Volume 2018, Issue 1, 2018., 2018 Emerging evidence suggests that cellular metabolism plays a critical role in regulating immune activation. Alterations in energy and lipid and amino acid metabolism have been shown to contribute to type I interferon (IFN) responses in macrophages, but the relationship between metabolic reprogramming and the establishment of early antiviral function ...
Duale Ahmed +6 more
wiley +1 more source
Brief Overview of a Decade of Genome‐Wide Association Studies on Primary Hypertension
International Journal of Endocrinology, Volume 2018, Issue 1, 2018., 2018 Primary hypertension is widely believed to be a complex polygenic disorder with the manifestation influenced by the interactions of genomic and environmental factors making identification of susceptibility genes a major challenge. With major advancement in high‐throughput genotyping technology, genome‐wide association study (GWAS) has become a powerful
Afifah Binti Azam +2 more
wiley +1 more source
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Enzymes
British Journal of Pharmacology, Volume 174, Issue S1, Page S272-S359, December 2017., 2017 The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand ...
Stephen PH Alexander +11 more
wiley +1 more source
Expression of endothelial nitric oxide synthase in the ovine ovary throughout the estrous cycle.
Reproduction, 2006 This study was conducted to evaluate the expression of endothelial nitric oxide synthase (eNOS) in ovarian follicles and corpora lutea (CL) throughout the estrous cycle in sheep.
A. Grazul-Bilska +5 more
semanticscholar +1 more source
Thin endometrium transcriptome analysis reveals a potential mechanism of implantation failure
Reproductive Medicine and Biology, Volume 16, Issue 2, Page 206-227, April 2017., 2017 Abstract Aim Although a thin endometrium has been well recognized as a critical factor in implantation failure, little information is available regarding the molecular mechanisms. The present study investigated these mechanisms by using genome‐wide mRNA expression analysis.
Ryo Maekawa +11 more
wiley +1 more source
Croatian Medical Journal, 2019 Aim To assess the effects of single nucleotide polymorphisms (SNPs) on blood pressure control in patients with obstructive sleep apnea (OSA). Methods This prospective observational cohort study, conducted between 2004 and 2014, examined the associations ...
I. Paranicova +7 more
semanticscholar +1 more source
The Identification of Key Genes and Pathways in Glioma by Bioinformatics Analysis
Journal of Immunology Research, Volume 2017, Issue 1, 2017., 2017 Glioma is the most common malignant tumor in the central nervous system. This study aims to explore the potential mechanism and identify gene signatures of glioma. The glioma gene expression profile GSE4290 was analyzed for differentially expressed genes (DEGs). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were applied
Mingfa Liu +9 more
wiley +1 more source
Cellular mediators of nitrergic neurotransmission in GI smooth muscles: no easy answer
Journal of Physiology, 2015 Gastrointestinal muscles receive both excitatory and inhibitory innervation, and both positive and negative influences impart important regulatory control of motility and transit.
K. Sanders, K. Keef
semanticscholar +1 more source
BioMed Research International, Volume 2017, Issue 1, 2017., 2017 The microRNA (miRNA) expression profiles and their biological functions in calcium oxalate nephrolithiasis remain unclear. In this study, we investigate the miRNA and mRNA expression profiles of kidney tissues in calcium oxalate stone rats. 16 Sprague Dawley rats were divided into control group and stone‐forming group.
Chuangxin Lan +12 more
wiley +1 more source