Maternal age effects on myometrial expression of contractile proteins, uterine gene expression, and contractile activity during labor in the rat [PDF]
, 2015 Advanced maternal age of first time pregnant mothers is associated with prolonged and dysfunctional labor and significant risk of emergency cesarean section.
Agarwal +138 more
core +2 more sources
Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages [PDF]
, 2015 Cognitive decline is associated with gene expression changes in the brain, but the transcriptional mechanisms underlying memory impairments in cognitive disorders, such as Alzheimer's disease (AD), are largely unknown.
Chen, M. +7 more
core +6 more sources
Traumatic Brain Injury Induces Genome-Wide Transcriptomic, Methylomic, and Network Perturbations in Brain and Blood Predicting Neurological Disorders. [PDF]
, 2017 The complexity of the traumatic brain injury (TBI) pathology, particularly concussive injury, is a serious obstacle for diagnosis, treatment, and long-term prognosis. Here we utilize modern systems biology in a rodent model of concussive injury to gain a
Agrawal, Rahul +5 more
core +2 more sources
Nitric oxide regulates synaptic transmission between spiny projection neurons [PDF]
, 2014 Recurrent axon collaterals are a major means of communication between spiny projection neurons (SPNs) in the striatum and profoundly affect the function of the basal ganglia.
Greengard, Paul +9 more
core +1 more source
Gentrepid V2.0: a web server for candidate disease gene prediction [PDF]
, 2013 Contains fulltext : 124935.pdf (publisher's version ) (Open Access)BACKGROUND: Candidate disease gene prediction is a rapidly developing area of bioinformatics research with the potential to deliver great benefits to human health.
Bains, Naresh +8 more
core +2 more sources
A genome‐wide association and replication study of blood pressure in Ugandan early adolescents
Molecular Genetics &Genomic Medicine, Volume 7, Issue 10, October 2019., 2019 Using the Entebbe Mother and Baby Study, we aimed to identify genetic variants associated with blood pressure (BP) among Ugandan adolescents. We conducted Genome‐wide association study (GWAS) and replication analysis for variants associated with BP. Variants showing suggestive associations are worthy of future investigation. Replication results suggest
Swaib A. Lule +15 more
wiley +1 more source
A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs [PDF]
, 2016 Chikungunya virus (CHIKV) is a globally spreading alphavirus against which there is no commercially available vaccine or therapy. Here we use a genome-wide siRNA screen to identify 156 proviral and 41 antiviral host factors affecting CHIKV replication ...
Berre, Stefano +16 more
core +5 more sources
Journal of Cellular and Molecular Medicine, Volume 23, Issue 4, Page 2526-2535, April 2019., 2019 Abstract Marfan syndrome (MFS) is an autosomal dominant genetic disorder caused by mutations in the FBN1 gene. Although many peripheral tissues are affected, aortic complications, such as dilation, dissection and rupture, are the leading causes of MFS‐related mortality.
Raghu Bhushan +10 more
wiley +1 more source
Regulation of intraocular pressure by soluble and membrane guanylate cyclases and their role in glaucoma [PDF]
, 2014 Glaucoma is a progressive optic neuropathy characterized by visual field defects that ultimately lead to irreversible blindness (Alward, 2000; Anderson et al., 2006).
Buys, Emmanuel S. +3 more
core +2 more sources
Evidence-Based Complementary and Alternative Medicine, Volume 2019, Issue 1, 2019., 2019 Systemic sclerosis (SSc) is a rare chronic autoimmune disorder, mainly characterized by skin sclerosis. In this study, Bufei Qingyu Granules (BQG), a Chinese herbal formula, was used to treat SSc. To better understand the effects and molecular mechanisms of BQG, we successfully established a Bleomycin‐ (BLM‐) induced SSc mouse model, and the mice were ...
Minhui Su +9 more
wiley +1 more source