Results 31 to 40 of about 106 (74)

The Immp2l mutation causes age‐dependent degeneration of cerebellar granule neurons prevented by antioxidant treatment

Aging Cell, Volume 15, Issue 1, Page 167-176, February 2016., 2016
Summary Reactive oxygen species are implicated in age‐associated neurodegeneration, although direct in vivo evidence is lacking. We recently showed that mice with a mutation in the Inner Mitochondrial Membrane Peptidase 2‐like (Immp2l) gene had elevated levels of mitochondrial superoxide, impaired fertility and age‐associated phenotypes, including ...
Chunlian Liu, Xue Li, Baisong Lu
wiley   +1 more source

Hypertension reduces expression of soluble guanylyl cyclase in the aorta via the Notch signaling pathway

The FASEB Journal, 2017
Hypertension is a dominating risk factor for cardiovascular morbidity and mortality. Here, aiming to characterize the genomic response of the vascular wall to hypertension, we administered physiological saline (NaCl, n=6) or angiotensin II (AngII, n=6 ...
C. Rippe, Baoyi Zhu, Katarzyna K. Krawczyk, Ed Van Bavel Van Bavel, Sebastian Albinsson, Jonas Sjölund, E. Bakker, K. Swärd   +7 more
semanticscholar   +1 more source

Comparative Microarray Analysis of Proliferating and Differentiating Murine ENS Progenitor Cells

Stem Cells International, Volume 2016, Issue 1, 2016., 2016
Postnatal neural progenitor cells of the enteric nervous system are a potential source for future cell replacement therapies of developmental dysplasia like Hirschsprung’s disease. However, little is known about the molecular mechanisms driving the homeostasis and differentiation of this cell pool.
Peter Helmut Neckel, Roland Mohr, Ying Zhang, Bernhard Hirt, Lothar Just, Kodandaramireddy Nalapareddy   +5 more
wiley   +1 more source

Defined PEG smears as an alternative approach to enhance the search for crystallization conditions and crystal‐quality improvement in reduced screens

Acta Crystallographica Section D, Volume 71, Issue 8, Page 1627-1639, August 2015., 2015
The quest for an optimal limited set of effective crystallization conditions remains a challenge in macromolecular crystallography, an issue that is complicated by the large number of chemicals which have been deemed to be suitable for promoting crystal growth.
Apirat Chaikuad, Stefan Knapp, Frank von Delft   +2 more
wiley   +1 more source

Gene expression changes caused by the p38 MAPK inhibitor dilmapimod in COPD patients: analysis of blood and sputum samples from a randomized, placebo‐controlled clinical trial

Pharmacology Research &Perspectives, Volume 3, Issue 1, February 2015., 2015
Abstract The p38 mitogen‐activated protein kinase (MAPK) intracellular signaling pathway responds to a variety of extracellular stimuli, including cytokines, Toll‐like receptor agonists, and components of cigarette smoke to influence the expression of proinflammatory mediators. Activation of p38 MAPK is increased within the lungs of chronic obstructive
Joanna C. Betts, Ruth J. Mayer, Ruth Tal‐Singer, Linda Warnock, Chris Clayton, Stewart Bates, Bryan E. Hoffman, Christopher Larminie, Dave Singh   +8 more
wiley   +1 more source

Luteal function during the estrous cycle in arginine-treated ewes fed different planes of nutrition.

Reproduction, 2017
Functions of corpus luteum (CL) are influenced by numerous factors including hormones, growth and angiogenic factors, nutritional plane and dietary supplements such as arginine (Arg), a semi-essential amino acid and precursor for proteins, polyamines and
C. Bass, D. Redmer, S. Kaminski, A. Grazul-Bilska   +3 more
semanticscholar   +1 more source

Effects of day of gestation and feeding regimen in Holstein × Gyr cows: III. Placental adaptations and placentome gene expression.

Journal of Dairy Science, 2015
This study investigated the influence of day of gestation (DG) and feeding regimens (FR) on the expression of genes responsible for placenta development, nutrient transfer, and angiogenic factors in Holstein × Gyr cows.
P. Rotta, P. Rotta, S. C. V. Filho, Tathyane R. S. Gionbelli, L. F. Silva, L. F. Silva, T. E. Engle, M. I. Marcondes, S. Guimarães, C. S. Nascimento, B. C. Carvalho, F. A. S. Silva, J.R.S. Oliveira   +12 more
semanticscholar   +1 more source

Plasma Soluble HLA-Bound Peptides Derived from Acute Myeloid Leukemia Patients during Induction May Predict Individual Response to Therapy

Blood, 2018
Introduction: Human leukocyte antigen (HLA) molecules are membrane-bound transporters carrying peptides from the cytoplasm to the cell surface where they become exposed to T lymphocytes. Soluble HLA molecules (sHLA) bound to their specific peptides are
M. Hayun, Chen Itzkovich, Eilon Barnea, A. Admon, Igal Louria‐Hayon, Y. Ofran   +5 more
semanticscholar   +1 more source

Effects of late gestational nutrient restriction on uterine artery blood flow, placental size, and cotyledonary mRNA expression in primiparous beef females

Journal of Animal Science
Fall-calving primiparous beef females [body weight (BW): 451 ± 28 (SD) kg; body condition score (BCS): 5.4 ± 0.7] were individually-fed either 100% (control; CON; n = 13) or 70% (nutrient restricted; NR; n = 13) of metabolizable energy and metabolizable ...
C. Redifer, Lindsey G Wichman, Abigail R Rathert-Williams, Allison M Meyer   +3 more
semanticscholar   +1 more source

The blood vessels development, morphogenesis and blood circulation are three ontologic groups highly up-regulated in porcine oocytes before in vitro maturation

, 2017
The mammalian oocytes undergo significant biochemical and structural modifications during maturation both in vitro and in vivo. These changes involve chromatin reorganization and modification within metabolic status of cytoplasmic organelles.
M. Nawrocki, P. Celichowski, J. Budna, A. Bryja, W. Kranc, S. Ciesiółka, S. Borys, Sandra Knap, M. Ješeta, R. Khozmi, D. Bukowska, P. Antosik, K. Brüssow, M. Bruska, M. Nowicki, M. Zabel, B. Kempisty   +16 more
semanticscholar   +1 more source