Results 51 to 60 of about 1,019 (115)

Use of a targeted, combinatorial next-generation sequencing approach for the study of bicuspid aortic valve [PDF]

, 2014
BACKGROUND: Bicuspid aortic valve (BAV) is the most common type of congenital heart disease with a population prevalence of 1-2%. While BAV is known to be highly heritable, mutations in single genes (such as GATA5 and NOTCH1) have been reported in few ...
David Newsom, Don Corsmeier, Elizabeth M Bonachea, Gloria Zender, Kim L McBride, Peter White, Sara Fitzgerald-Butt, Vidu Garg   +7 more
core   +2 more sources

Candidate disease gene prediction using Gentrepid: application to a genome‐wide association study on coronary artery disease

Molecular Genetics &Genomic Medicine, Volume 2, Issue 1, Page 44-57, January 2014., 2014
The application of a candidate disease gene prediction tool to a genome‐wide association study on coronary artery disease revealed numerous novel candidates. The method and results of this analysis using protein networks and protein functional domains are presented here, along with the candidates.
Sara Ballouz, Jason Y. Liu, Martin Oti, Bruno Gaeta, Diane Fatkin, Melanie Bahlo, Merridee A. Wouters   +6 more
wiley   +1 more source

Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice [PDF]

, 2015
Oxidative stress, a central mediator of cardiovascular disease, results in loss of the prosthetic haem group of soluble guanylate cyclase (sGC), preventing its activation by nitric oxide (NO). Here we introduce Apo-sGC mice expressing haem-free sGC.
Bloch, Kenneth D, Brouckaert, Peter, Buys, Emmanuel S, Cauwels, Anje, De Cauwer, Lode, Decaluwé, Kelly, Delanghe, Joris, Geschka, Sandra, Hochepied, Tino, Karas, Richard H, Rogge, Elke, Sips, Patrick, Stasch, Johannes-Peter, Tainsh, Robert E, Thoonen, Robrecht, Van de Voorde, Johan, Voet, Sofie, Vuylsteke, Marnik   +17 more
core   +1 more source

Gene Expression Profile of Increased Heart Rate in Shensongyangxin‐Treated Bradycardia Rabbits

Evidence-Based Complementary and Alternative Medicine, Volume 2014, Issue 1, 2014., 2014
Aims. The present study tries to investigate the gene expression profile of bradycardia rabbits’ hearts after SSYX (SSYX, a traditional Chinese medicine) treatment. Methods. Eighteen adult rabbits were randomly assigned in three groups: sham, model, and SSYX treatment groups.
Zhouying Liu, Jian Huang, Roumu Hu, Youping Huo, Jing Gong, Yinhui Zhang, Cong Wei, Jielin Pu, Adair Santos   +8 more
wiley   +1 more source

Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery. [PDF]

, 2017
Neurite initiation is the first step in neuronal development and occurs spontaneously in soft tissue environments. Although the mechanisms regulating the morphology of migratory cells on rigid substrates in cell culture are widely known, how soft ...
Chang, Ting-Ya, Chang, Ya-Chu, Chen, Chen, Cheng, Pei-Lin, Guo, Chin-Lin, Lee, Min, Lu, Chi-Huan, Lu, Shao-Tzu, Wang, Aijun, Wang, De-Yao   +9 more
core   +2 more sources

Vascular Histomolecular Analysis by Sequential Endoarterial Biopsy in a Shunt Model of Pulmonary Hypertension

Pulmonary Circulation, Volume 3, Issue 1, Page 50-57, January 2013., 2013
The molecular mechanisms of pulmonary arterial hypertension (PAH) remain ill‐defined. The aims of this study were to obtain sequential endoarterial biopsy samples in a surgical porcine model of PAH and assess changes in histology and mRNA expression during the disease progression.
Abraham Rothman, Stephanie Davidson, Robert G. Wiencek, William N. Evans, Humberto Restrepo, Valeri Sarukhanov, Erkki Ruoslahti, Roy Williams, David Mann   +8 more
wiley   +1 more source

NCR‐PCOPGene: An Exploratory Tool for Analysis of Sample‐Classes Effect on Gene‐Expression Relationships

Advances in Bioinformatics, Volume 2008, Issue 1, 2008., 2008
Background. Microarray technology is so expensive and powerful that it is essential to extract maximum value from microarray data. Our tools allow researchers to test and formulate from a hypothesis to entire models. Results. The objective of the NCRPCOPGene is to study the relationships among gene expressions under different conditions, to classify ...
Juan Cedano, Mario Huerta, Enrique Querol, Pierre Rouzé   +3 more
wiley   +1 more source

Topological Analysis of Metabolic Networks Integrating Co-Segregating Transcriptomes and Metabolomes in Type 2 Diabetic Rat Congenic Series [PDF]

, 2016
Background: The genetic regulation of metabolic phenotypes (i.e., metabotypes) in type 2 diabetes mellitus is caused by complex organ-specific cellular mechanisms contributing to impaired insulin secretion and insulin resistance.
Argoud, K, Ayala, R, Calderari, S, Cazier, JB, Collins, S, Domange, C, Dumas, ME, Gauguier, D, Gu, Q, Holmes, E, Hue, C, Lindon, JC, Mitchell, S, Navratil, V, Nicholson, JK, Otto, GW, Rodriguez Martinez, A, Suárez-Zamorano, N, Wallis, R, Wang, Y, Wilder, S   +20 more
core   +6 more sources

Transfection of Sertoli cells with androgen receptor alters gene expression without androgen stimulation [PDF]

, 2015
Background: Androgens play an important role for the development of male fertility and gained interest as growth and survival factors for certain types of cancer.
Bergmann, M., Chakraborty, Trinad, Fietz, Daniela, Geyer, J., Hossain, Hamid, Kliesch, S., Konrad, L., Lang, D., Markmann, M.   +8 more
core   +3 more sources

Identifying novel hypoxia-associated markers of chemoresistance in ovarian cancer [PDF]

, 2015
BACKGROUND Ovarian cancer is associated with poor long-term survival due to late diagnosis and development of chemoresistance. Tumour hypoxia is associated with many features of tumour aggressiveness including increased cellular proliferation ...
Blackshields, Gordon, Gallagher, Michael F., Martin, Cara M., McEvoy, Lynda M., O'Leary, John J., O'Toole, Sharon A., Sheils, Orla, Spillane, Cathy D., Stordal, Britta K.   +8 more
core   +1 more source