Results 61 to 70 of about 84,005 (291)

Hot Deformation Behavior and Constitutive Modeling of H13-Mod Steel

Metals, 2018
The H13-mod steel optimized by composition and heat treatment has reached the performance index of the shield machine hob. The hot deformation behavior of the H13-mod steel was investigated by compression tests in the temperature range from 900 to 1150 ...
Changmin Li, Yuan Liu, Yuanbiao Tan, Fei Zhao   +3 more
doaj   +1 more source

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu, Haojie Chen, Xiang Li, Jingxin Liu, Yiwen Li, Zhenyi Shi, Shenshen Guo, Qingfeng Du, Aiping Lu, Daogang Guan   +9 more
wiley   +1 more source

NIPAL1 Drives a Metabolic‐Epigenetic Feedback Loop to Promote Lactate‐Mediated Immune Evasion in Esophageal Cancer

Advanced Science, EarlyView.
The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen, Xiao‐Dan Ma, Shui‐Dan Xu, Ao‐Tian Mo, Min‐Hua Deng, Jun‐Han Wu, Wei‐Tao Zhuang, Jin‐Ling Duan, Shu‐Huan Xie, Jin‐Long Lin, Peng Lin, Ji‐Ming Tang, Hai‐Yu Zhou, Xiao‐Song Ben, Gui‐Bin Qiao, Dan Xie   +15 more
wiley   +1 more source

RESEARCH OF THE INFLUENCE OF MODERN TRENDS IN UI/ UX DESIGN OF MOBILE APPLICATIONS ON USER’S MOOD

Автоматизация технологических и бизнес-процессов
: The research explores the impact of modern trends in UI/UX design on the mood of users interacting with mobile applications. Through an analysis of literature and a survey of IT students, the study evaluates the emotional resonance of seven ...
A. S. Zhadan, O. O. Sichkar, D. A. Pishkin   +2 more
doaj   +1 more source

Selectivity Filter Dynamics Define Ion Conductance and Selectivity Differences in CNG and HCN Channels

Advanced Science, EarlyView.
Cyclic nucleotide‐gated (CNG) and hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels share substantial sequence and structural similarity but differ markedly in ion conductance and K+ selectivity. Microsecond‐scale atomistic MD simulations qualitatively reproduced the conductance differences observed in single‐channel recordings and ...
Haoran Liu, Klaus Benndorf, Yessenbek K. Aldakul, Han Sun   +3 more
wiley   +1 more source

Masquerade Detection Using GUI Events in Windows Systems

International Journal of Information and Communication Technology Research, 2011
Masquerade attack in computer systems refers to the illegitimate user activities while pretending to be legitimate user. Detection of such attacks is done by discovering significant changes in user's behavior based on his profile.
Parisa Kaghazgaran, Babak Sadeghyan
doaj  

Crystal structure of tris((2-(2,2-dicyanovinyl)phenoxy)ethyl)amine, C36H27N7O3

Zeitschrift für Kristallographie - New Crystal Structures, 2016
C36H27N7O3, P21/n (no. 14), a = 8.469(3) Å, b = 19.345(6) Å, c = 19.517(6) Å, α = γ = 90.00°, β = 95.337(5)°, V = 3183.7(17) Å3, Z = 4, Rgt(F) = 0.0538, wRref(F2) = 0.1187, T = 293.
Yin Xiao-Gang, Zuo Zhen-Yu, Chen Zhi-Ming, Gong Wei, Chen Zhuo   +4 more
doaj   +1 more source

Modular Generation of Alkyl Selenyl Radicals for the Synthesis of Alkyl Selenides via a Mechanochemical Approach

Advanced Science, EarlyView.
We present a mechanochemical, radical‐mediated hydroselenation of alkenes under ambient conditions. This method modularly generates alkyl selenyl radicals from elemental selenium and alkyl (pseudo)halides, utilizing PhSiH3 and H2O as hydrogen atom donors, with the water likely originating from the air and/or trace water present in the reagents ...
Xiaochun He, Yu Zhou, Fei Zhou, Zixi Ai, Peiyu Hu, Xuemei Zhang, Xiaofeng Wei, Gui‐Juan Cheng, Zhong Lian   +8 more
wiley   +1 more source

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

Innovative Metasurface Colorimetric Cell‐on‐a‐Chip Sensor for Continuous, Label‐Free, Non‐Destructive Assessment of Intestinal Barrier Dynamics

Advanced Science, EarlyView.
We developed a real‐time, label‐free, high‐throughput cell‐on‐a‐chip system based on a metasurface plasmon resonance colorimetric sensor (MetaSPRCS) to evaluate intestinal barrier function. This platform enables continuous monitoring of cell adhesion, proliferation, and barrier layer formation, disruption, and repair.
Youqian Chen, Wen Li, Jiaying Feng, Yue Shu, Yihui Yang, Yuyan Wang, Rui Li, Hanlin Zhou, Xinfan Yang, Yuxue Guo, Mingqian Chen, Wenjun Hu, Gang Logan Liu, Liping Huang, Yanan Li   +14 more
wiley   +1 more source