Results 191 to 200 of about 9,297,024 (336)

In vivo screen reveals specific roles of Hippo pathway components in development and regeneration. [PDF]

Life Sci Alliance
Riley SE, Noskova Fairley M, Xia S, Cunningham R, Cholewa-Waclaw J, Feng Y, Hansen CG.   +6 more
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Developing updated and new guidance to promote reliable patient identification. [PDF]

JAMIA Open
Weatherford E, Grauer A, Sirochinsky C, Lehman IF, Thummala N, Callahan M, Sittig DF, Singh H, Salmasian H, Jurgens M, Adelman JS.   +10 more
europepmc   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Evaluation of the Accuracy of Intraoperative Femoral Stem Anteversion Using a Mechanical Alignment Guide and a CT-Based Navigation System. [PDF]

Cureus
Masumoto Y, Fukunishi S, Nakai T, Tachibana T.   +3 more
europepmc   +1 more source

P-98 Developing guides for use of specialist subcutaneous medications for end-of-life care in the community [PDF]

Claire Stark Toller, Samuel Teong Huang Chew, Laura Deacon   +2 more
openalex   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

More tricks with tetramers: a practical guide to staining T cells with peptide–MHC multimers [PDF]

, 2015
Garry Dolton, Katie Tungatt, Angharad Lloyd, Valentina Bianchi, Sarah M. Theaker, Andrew Trimby, Christopher Holland, Marco Donia, Andrew Godkin, David K. Cole, Per thor Straten, Mark Peakman, Inge Marie Svane, Andrew K. Sewell   +13 more
openalex   +1 more source

Application of the navigation guide systematic review methodology to evaluate prenatal exposure to particulate matter air pollution and infant birth weight

, 2021
Inyang Uwak, Natalie Olson, Angelica M. Fuentes, Megan Moriarty, Jairus C. Pulczinski, Juleen Lam, Xiaohui Xu, Brandie D. Taylor, Samuel Taiwo, Kirsten Koehler, Margaret Foster, Weihsueh A. Chiu, Natalie M. Johnson   +12 more
openalex   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source