Results 231 to 240 of about 9,297,024 (336)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Medial meniscus posterior root tear repair: An overview of surgical techniques and augmentation strategies. [PDF]

J Exp Orthop
Cortina G, Perelli S, Pizza N, Condello V, Madonna V, Monllau JC.   +5 more
europepmc   +1 more source

Basketball Guide, 1996-97 [PDF]

, 1996
Bryant University,
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Neurosurgeons' knowledge, attitudes, and practices regarding 3D-printed guide plate-guided puncture and drainage surgery for intracerebral hemorrhage. [PDF]

Sci Rep
Kang S, Zhao C, Fan Y, Zhao J.
europepmc   +1 more source

A Practitioner's Guide to the Promissory Note Requirement in C.R.C.P. 121, Section 1-14(F)

, 2014
Forrest Plesko
openalex   +1 more source

Basketball Guide, 1973-74 [PDF]

, 1973
Bryant University,
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Taxonomy of cognitive operations as a guide for the design of a professional medical examination

Alfonso Navarro‐Zapata, Amílcar Alpuche-Hernández, Armando Ortíz Montalvo, Adrián Martínez-González   +3 more
openalex   +1 more source

Faculty Guide 2016-2017 [PDF]

, 2016
Folmer, Fred
core   +1 more source