Results 281 to 290 of about 9,297,024 (336)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

CURE: Curriculum-guided Multi-task Training for Reliable Anatomy Grounded Report Generation [PDF]

Pablo Messina, Andrés Villa, Juan León Alcázar, Karen Sánchez, Carlos Hinojosa, Denis Parra, Álvaro Soto, Bernard Ghanemm   +7 more
openalex  

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Application of patient-specific surgical guides in foot and ankle surgery. [PDF]

Acta Orthop Traumatol Turc
Kavak S, Ozturk B, Ogut T, DiGiovanni CW, Ashkani-Esfahani S, Karaismailoglu B.   +5 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Argonaute-mediated RNA editing selectively repairs point mutations. [PDF]

Nucleic Acids Res
Zhang Z, Wang J, Guo T, Yu X, Wang F, Zhang H, Liu Y, Li W, Cheng Y, Peng Y, Yan G, Cui J, Ma L.   +12 more
europepmc   +1 more source

Coping with Pokes: Child, Caregiver, and Clinician Feedback on a Caregiver-Led Educational Resource for Managing Children's Needle Fear. [PDF]

Nurs Rep
Nauman H, Truffyn EE, Taddio A, Birnie KA, McMurtry CM.   +4 more
europepmc   +1 more source

Integrated DEP presorting and wireless electrode array for high-throughput selective single-cell isolation.

Lab Chip
Rathnaweera TN, Rajkumar D, Anand RK.
europepmc   +1 more source

Prefabricated 3D-printed full-arch implant for functional and esthetic rehabilitation: a prosthesis-integrated drill guide solution. [PDF]

3D Print Med
Bai H, Wu W, Ge X, Wang Z.
europepmc   +1 more source

Evaluation of 3-Dimensional accuracy of guided implant placement using guided osteoperiosteal flap versus guided ridge splitting for atrophic maxillary augmentation (a randomized clinical trial). [PDF]

BMC Oral Health
Salem OAEH, Elmahlawy AS, Saber ME.
europepmc   +1 more source