Results 161 to 170 of about 570,529 (349)

Predicting Distance matrix with large language models [PDF]

arXiv
Structural prediction has long been considered critical in RNA research, especially following the success of AlphaFold2 in protein studies, which has drawn significant attention to the field. While recent advances in machine learning and data accumulation have effectively addressed many biological tasks, particularly in protein related research.
arxiv  

Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs [PDF]

, 2002
Xavier Darzacq, Beáta E. Jády, Céline Verheggen, Arnold M. Kiss, Édouard Bertrand, Tamás Kiss   +5 more
openalex   +1 more source

NanoCMSer: a consensus molecular subtype stratification tool for fresh‐frozen and paraffin‐embedded colorectal cancer samples

Molecular Oncology, EarlyView.
Consensus molecular subtypes (CMS1‐4) have been identified to study colorectal cancer heterogeneity and serve as potential biomarkers. In this study, we developed and evaluated NanoCMSer, a NanoString‐based classifier using 55 genes, optimized for FF and FFPE to facilitate the clinical evaluation of CMS subtyping.
Arezo Torang, Simone van de Weerd, Veerle Lammers, Sander van Hooff, Inge van den Berg, Saskia van den Bergh, Miriam Koopman, Jan N. IJzermans, Jeanine M. L. Roodhart, Jan Koster, Jan Paul Medema   +10 more
wiley   +1 more source

Guide RNA resource for Drosophila [PDF]

Nature Methods, 2020
openaire   +3 more sources

Selective RNA pseudouridinylation in situ by circular gRNAs in designer organelles

Nature Communications
RNA modifications play a pivotal role in the regulation of RNA chemistry within cells. Several technologies have been developed with the goal of using RNA modifications to regulate cellular biochemistry selectively, but achieving selective and precise ...
Lukas Schartel, Cosimo Jann, Anna Wierczeiko, Tamer Butto, Stefan Mündnich, Virginie Marchand, Yuri Motorin, Mark Helm, Susanne Gerber, Edward A. Lemke   +9 more
doaj   +1 more source

Archaeal Guide RNAs Function in rRNA Modification in the Eukaryotic Nucleus [PDF]

, 2002
Wayne Speckmann, Zhu‐Hong Li, Todd M. Lowe, Sean R. Eddy, Rebecca M. Terns, Michael P. Terns   +5 more
openalex   +1 more source

Genome-wide DNA sampling by Ago nuclease from the cyanobacterium Synechococcus elongatus [PDF]

, 2020
Members of the conserved Argonaute (Ago) protein family provide defense against invading nucleic acids in eukaryotes in the process of RNA interference. Many prokaryotes also contain Ago proteins that are predicted to be active nucleases, however, their ...
Aravin, Alexei A., Esyunina, Daria, Kulbachinskiy, Andrey, Kuzmenko, Anton, Ninova, Maria, Olina, Anna   +5 more
core  

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Guiding Cas13 for RNA knockdown [PDF]

Nature Methods, 2020
openaire   +3 more sources

In vitro RNP assembly and methylation guide activity of an unusual box C/D RNA, cis-acting archaeal pre-tRNATrp [PDF]

, 2003
Marie‐Line Bortolin‐Cavaillé
openalex   +1 more source