Results 191 to 200 of about 4,450,920 (398)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Short oligonucleotides as external guide sequences for site-specific cleavage of RNA molecules with human RNase P

, 1998
Martina Werner, Eddie Rosa, Jeffrey L. Nordstrom, Allan R. Goldberg, Shaji T. George   +4 more
openalex   +1 more source

A rough guide to the non‐coding RNA world of Salmonella [PDF]

, 2008
Jörg Vogel
openalex   +1 more source

Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA

Cell, 2016
T. Yamano, H. Nishimasu, Bernd Zetsche, H. Hirano, I. Slaymaker, Yinqing Li, I. Fedorova, T. Nakane, K. Makarova, E. Koonin, R. Ishitani, Feng Zhang, O. Nureki   +12 more
semanticscholar   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Reviewer #1 (Public Review): Specific Modulation of CRISPR Transcriptional Activators through RNA-Sensing Guide RNAs in Mammalian Cells and Zebrafish Embryos [PDF]

, 2023
Pelea Oana, Mayes Sarah, Ferry Quentin RV., Fulga Tudor A., Sauka-Spengler Tatjana   +4 more
openalex   +1 more source

A novel RNA-guided RNA-targeting CRISPR tool [PDF]

Science China Life Sciences, 2016
Zhang, Dandan, Li, Zhenxiang, Yan, Bingyu, Li, Jian-Feng   +3 more
openaire   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Structure and engineering of Brevibacillus laterosporus Cas9

Communications Biology
The RNA-guided DNA endonuclease Cas9 cleaves double-stranded DNA targets complementary to an RNA guide, and is widely used as a powerful genome-editing tool.
Toshihiro Nakane, Ryoya Nakagawa, Soh Ishiguro, Sae Okazaki, Hideto Mori, Yutaro Shuto, Keitaro Yamashita, Nozomu Yachie, Hiroshi Nishimasu, Osamu Nureki   +9 more
doaj   +1 more source

Unlocking the potential of CRISPR tools and databases for precision genome editing

Frontiers in Plant Science
Recent breakthroughs in CRISPR/Cas genome editing have transformed molecular biology research and offer significant potential across biotechnology and medicine.
Pooja Saraswat, Rajiv Ranjan
doaj   +1 more source