Results 341 to 350 of about 4,450,920 (398)

A pipeline for identifying guide RNA sequences that promote RNA editing of nonsense mutations that cause inherited retinal diseases. [PDF]

Mol Ther Nucleic Acids
Schneider N, Steinberg R, Ben-David A, Valensi J, David-Kadoch G, Rosenwasser Z, Banin E, Levanon EY, Sharon D, Ben-Aroya S.   +9 more
europepmc   +1 more source

Guide RNA scaffold variants enabled easy cloning of large gRNA cluster for multiplexed gene editing. [PDF]

Plant Biotechnol J
Wang Y, Li X, Liu M, Zhou Y, Li F.
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Genomic and Transcriptomic Analyses of Prime Editing Guide RNA–Independent Off-Target Effects by Prime Editors

The CRISPR Journal, 2022
Prime editors (PEs) were developed to induce versatile edits at a guide-specified genomic locus. With all RNA-guided genome editors, guide-dependent off-target (OT) mutations can occur at other sites bearing similarity to the intended target.
Runze Gao, Zhicong Fu, Xiangyang Li, Ying Wang, Jia Wei, Guangye Li, Lijie Wang, Jing Wu, Xingxu Huang, Li Yang, Jia Chen   +10 more
semanticscholar   +1 more source

Controlling CRISPR‐Cas9 by guide RNA engineering

Wiley Interdisciplinary Reviews - RNA, 2022
The clustered regularly interspaced short palindromic repeats (CRISPR) system is a product of million years of evolution by microbes to fight against invading genetic materials.
Lu-Feng Hu, Yu-Xuan Li, Jia-Zhen Wang, Yu-Ting Zhao, Yangming Wang   +4 more
semanticscholar   +1 more source

RNA-Guided RNA Modifications: Biogenesis, Functions, and Applications

Accounts of Chemical Research, 2023
Post-transcriptional modifications are ubiquitous in both protein-coding and noncoding RNAs (ncRNAs), playing crucial functional roles in diverse biological processes across all kingdoms of life. These RNA modifications can be achieved through two distinct mechanisms: RNA-independent and RNA-guided (also known as RNA-dependent).
Bin Li, Lianghu Qu, Jianhua Yang
openaire   +2 more sources

Chimeric DNA–RNA Guide RNA Designs

2020
CRISPR-associated nuclease (Cas) has been widely applied to modify the genomes of various cell types. As RNA-guided endonucleases, Cas enzymes can target different genomic sequences simply by changing the guide sequence of the CRISPR RNA (crRNA) or single guide RNA (sgRNA).
Shuhan, Lu, Ying, Zhang, Hao, Yin
openaire   +2 more sources

RNA: Guiding Gene Silencing

Science, 2001
In diverse organisms, small RNAs derived from cleavage of double-stranded RNA can trigger epigenetic gene silencing in the cytoplasm and at the genome level. Small RNAs can guide posttranscriptional degradation of complementary messenger RNAs and, in plants, transcriptional gene silencing by methylation of homologous DNA sequences.
M, Matzke, A J, Matzke, J M, Kooter
openaire   +2 more sources

RNA-guided DNA assembly

Journal of Theoretical Biology, 2007
We propose molecular models for homologous DNA recombination events that are guided by either double-stranded RNA (dsRNA) or single-stranded RNA (ssRNA) templates. The models are applied to explain DNA rearrangements in some groups of ciliates, such as Stylonychia or Oxytricha, where extensive gene rearrangement occurs during differentiation of a ...
Angeleska, Angela, Jonoska, Nataša, Saito, Masahico, Landweber, Laura F.   +3 more
openaire   +2 more sources

RNA guides genome engineering

Nature Biotechnology, 2013
The Cas9 endonuclease is reprogrammed by RNAs for site-specific modification of eukaryotic and microbial genomes.
Mussolino, Claudio, Cathomen, Toni
openaire   +2 more sources

RNA Editing: RNA duplexes guide base conversions

Current Biology, 1994
Recent evidence strengthens the case that editing of mRNAs encoding glutamate receptors subunits occurs by a mechanism in which the RNA editing substrate has a double-stranded conformation.
openaire   +2 more sources