Results 351 to 360 of about 4,450,920 (398)

Small Nucleolar RNAs Guide Ribosomal RNA Methylation

Science, 1996
Two recent reports, one in Cell and one in the Journal of Molecular Biology , show that the newly described small nucleolar RNAs control the site of methylation of the ribosomal RNA (rRNA). Tollervey explains how these small RNAs accomplish this targeting and discusses the possible role of ...
openaire   +2 more sources

Characterization of Cas9–Guide RNA Orthologs

Cold Spring Harbor Protocols, 2016
In light of the multitude of new Cas9-mediated functionalities, the ability to carry out multiple Cas9-enabled processes simultaneously and in a single cell is becoming increasingly valuable. Accomplishing this aim requires a set of Cas9–guide RNA (gRNA) pairings that are functionally independent and insulated from one another.
Jonathan L. Braff, Stephanie J. Yaung, Kevin M. Esvelt, George M. Church   +3 more
openaire   +2 more sources

Small nucleolar RNAs and RNA-guided post-transcriptional modification

Essays in Biochemistry, 2013
snoRNAs (small nucleolar RNAs) constitute one of the largest and best-studied classes of non-coding RNAs that confer enzymatic specificity. With associated proteins, these snoRNAs form ribonucleoprotein complexes that can direct 2′-O-methylation or pseudouridylation of target non-coding RNAs.
Lauren, Lui, Todd, Lowe
openaire   +2 more sources

Lentiviral delivery of co-packaged Cas9 mRNA and a Vegfa-targeting guide RNA prevents wet age-related macular degeneration in mice

Nature Biomedical Engineering, 2021
Sikai Ling, Shiqi Yang, Xinde Hu, Di Yin, Yao Dai, Xiaoqin Qian, Dawei Wang, Xiaoyong Pan, Jiaxu Hong, Xiaodong Sun, Hui Yang, S. Paludan, Yujia Cai   +12 more
semanticscholar   +1 more source

Increasing the efficiency and precision of prime editing with guide RNA pairs

Nature Chemical Biology, 2021
Zhuang Yuan, Jiangle Liu, Hao Wu, Qingguo Zhu, Yongchang Yan, Haowei Meng, Peng R. Chen, C. Yi   +7 more
semanticscholar   +1 more source

RNA‐Guided RNA Pseudouridylation and 2’‐O‐Methylation

Israel Journal of Chemistry
AbstractRNA‐guided RNA modifications, including pseudouridylation and 2′‐O‐methylation, are naturally occurring processes that introduce pseudouridines (Ψ) and 2’‐O‐methylated residues (2’‐O−Me) into various types of RNA. This modification is orchestrated by two distinct families of ribonucleoprotein complexes: Box H/ACA RNP and Box C/D RNP.
Hironori Adachi, Jonathan L. Chen, W.‐Matthias Leeder, Pedro Morais, Yi‐Tao Yu   +4 more
openaire   +1 more source

Acquiring tissue for advanced lung cancer diagnosis and comprehensive biomarker testing: A National Lung Cancer Roundtable best‐practice guide

Ca-A Cancer Journal for Clinicians, 2023

exaly  

How can hospitals change practice to better implement smoking cessation interventions? A systematic review

Ca-A Cancer Journal for Clinicians, 2022
Anna Ugalde, Vicki White, Nicole M Rankin   +2 more
exaly  

Guide RNAs and guide RNA genes in the cryptobiid kinetoplastid protozoan, Trypanoplasma borreli.

RNA (New York, N.Y.), 1996
Trypanoplasma borreli belongs to the bodonid/cryptobiid group of kinetoplastid protozoa, which represents a sister group to the trypanosomatids. RNA transcripts from several mitochondrial genes in this organism undergo the trypanosomatid type of uridine addition/deletion RNA editing.
S, Yasuhira, L, Simpson
openaire   +1 more source

A Hitchhiker’s Guide to Click-Chemistry with Nucleic Acids

Chemical Reviews, 2021
Nicolo Zuin Fantoni, Afaf El-Sagheer, Tom Brown   +2 more
exaly