Results 131 to 140 of about 71,451 (265)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

High-Q multimodal guided-surface lattice resonances in index-discontinuous environments. [PDF]

Nat Commun
Huang S, Yao K, Wang H, Ding X, Li F, Huang C, Huang W, Zhao X, Zheng Y, Pan Y.   +9 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

TiO₂-coated guided-mode resonance gratings for polarization-selective green light filtering. [PDF]

Discov Nano
Aslam K, Mushtaq N, Chai Y, Kang G.
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Delamination Localization in CFRP Laminates Using One-Way Mixing of Ultrasonic Guided Waves. [PDF]

Sensors (Basel)
Sun M, Liu Y, Li L, Zhang X, Xiao B, Zhang Y, Liu H.   +6 more
europepmc   +1 more source

A free plate model can predict guided modes propagating in tubular bone-mimicking phantoms. [PDF]

J Acoust Soc Am, 2015
Minonzio JG, Foiret J, Moilanen P, Pirhonen J, Zhao Z, Talmant M, Timonen J, Laugier P.   +7 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Freestanding Polymer Metasurface Supporting Higher-Order Optical Resonances for Strong Field Enhancement in TMD Monolayers. [PDF]

Small
Deng CZ, Shi S, Chiang CH, Chen MH, Liu S, Sakurai H, Fu JH, Konishi K, Iwanaga M, Tung V, Ho YL.   +10 more
europepmc   +1 more source