Results 41 to 50 of about 59,577 (303)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Treatment of Gingival Recession [PDF]

, 2010
Gingival recession is an intriguing and complex phenomenon. Recession frequently disturbs patients because of sensitivity and esthetics. Many surgical techniques have been introduced to treat gingival recession, including those involving autogenous ...
Badawi, Hala, Dentino, Andrew R., Kassab, Moawia M   +2 more
core   +1 more source

Synthesis and characterization of novel scaffold for bone tissue engineering based on Whartons´s jelly [PDF]

, 2017
A composite is a material made of more than one component, and the bond between the components is on a scale larger than the atomic scale. The objective of the present study was to synthesize and perform the structural characterization and biological ...
Aniket, Aniket, Bakhtiari, Barbeck, Boryskina, Cabrini, Camacho, Cao, Carlton, Chang, Desimone, Dhimolea, El-Ghannam, El-Ghannam, Fan, Fong, Franz, Ghanaati, Guo, Hanjaya-Putra, Heinemann, Hench, Hench, Hench, Hench, Henkel, Herten, Hutmacher, Kandamchira, Katti, Kikuchi, Kim, Kisiel, Klein, Lee, Letaief, Leu, Li, Li, Li, Libonati, Lin, Liu, Ma, MacDuff, Meng, Oonishi, Pek, Petite, Plewinski, Qian, Quinlan, Quinlan, Rodrigues, Roveri, Salgado, Salma-Ancane, Santos, Scalera, Schneider, Sha, Shin, Singh, Sionkowska, Sobolewski, Taghizadeh, Tamimi, Tapety, Twardowski, Vidal, Xu, Zhang   +71 more
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration. [PDF]

, 2014
The regenerative capacity of skeletal muscle declines with age. Previous studies suggest that this process can be reversed by exposure to young circulation; however, systemic age-specific factors responsible for this phenomenon are largely unknown.
Chen, Robert Y, Chooljian, Marc S, Conboy, Irina M, Cousin, Wendy, Elabd, Christian, Jiang, Kevin P, Kung, Sunny, Li, Ju, Upadhyayula, Pavan   +8 more
core   +1 more source

Biostimulatory effects of simvastatin on MDPC-23 odontoblast-like cells

Brazilian Oral Research, 2017
: The aim of this study was to evaluate the bioactivity and cytocompatibility of simvastatin (SV) applied to MDPC-23 odontoblast-like cells. For this purpose, MDPC-23 cells were seeded in 96-well plates and submitted to treatments with 0.01 or 0.1 μM of ...
Maria Luísa de Alencar e Silva Leite, Diana Gabriela Soares, Fernanda Gonçalves Basso, Josimeri Hebling, Carlos Alberto de Souza Costa   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Current Overview of Materials and Strategies for Potential Use in Maxillofacial Tissue Regeneration [PDF]

, 2017
Tissue regeneration is rapidly evolving to treat anomalies in the entire human body. The production of biodegradable, customizable scaffolds to achieve this clinical aim is dependent on the interdisciplinary collaboration among clinicians, bioengineers ...
Almeida, Luis Eduardo, Dashtimoghadam, Erfan, Fahimipour, Farahnaz, Jazayeri, Hossein E., Khoshroo, Kimia, Razavi, Mehdi, Tahriri, Mohammadreza, Tayebi, Lobat   +7 more
core   +1 more source

Treatment of a Localized Stage III Periodontitis in the Esthetic Zone with Guided Tissue Regeneration Technique on a Heavy Smoker Patient with 12-Year Follow- up: A Case Report [PDF]

Journal of Dentistry
This case report exhibits a heavy smoker female patient with a localized stage III periodontitis who has been under cessation smoking program during the pre-surgical period, followed by a strict maintenance program for the past twelve years, after being ...
Fatme Hamasni, Fadi El Hajj
doaj   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source