Results 41 to 50 of about 2,352,224 (278)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Open Guided Waves: online platform for ultrasonic guided wave measurements [PDF]

open access: yesStructural Health Monitoring, 2018
Ultrasonic guided waves have been used successfully in structural health monitoring systems to detect damage in isotropic and composite materials with simple and complex geometry. A limitation of current research is given by a lack of freely available benchmark measurements to comparatively evaluate existing methods.
Jochen Moll   +8 more
openaire   +4 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

open access: yesFEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana   +5 more
wiley   +1 more source

Signal Enhancement Technology Based on Ultrasonic Guided Wave Rail Bottom Crack Detection

open access: yesChengshi guidao jiaotong yanjiu
[Objective] During the propagation of guided waves in rails, there are problems of poor anti-interference ability and severe signal attenuation, which hinder the identification of rail bottom cracks.
HE Jiping   +7 more
doaj   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

open access: yesFEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

Fatigue Crack Evaluation with the Guided Wave–Convolutional Neural Network Ensemble and Differential Wavelet Spectrogram

open access: yesSensors, 2021
On-line fatigue crack evaluation is crucial for ensuring the structural safety and reducing the maintenance costs of safety-critical systems. Among structural health monitoring (SHM), guided wave (GW)-based SHM has been deemed as one of the most ...
Jian Chen   +3 more
doaj   +1 more source

The Hitchhiker’s Guide to the Wave Function

open access: yesThe Journal of Physical Chemistry A, 2022
The electronic wave function of molecules is 3N-dimensional and inseparable in the coordinates of the N electrons. Whereas molecular orbitals are often invoked to visualize the electronic structure, they are nonunique, with the same 3N-dimensional wave function being represented by an infinite number of 3-D, one-electron functions (orbitals ...
Liu, Y, Frankcombe, TJ, Schmidt, TW
openaire   +3 more sources

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi   +8 more
wiley   +1 more source

Propagation Characteristics and Defect Sensitivity Analysis of Guided Wave From Single Excitation Source in Elbows

open access: yesIEEE Access, 2019
Ultrasonic guided wave has received significant attention in the field of nondestructive testing because of their advantages in detecting the entire wall thickness.
Yu Wang, Xueyi Li
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

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