ELABELA Targets Mitochondria to Modulate Heart Development
The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang +22 more
wiley +1 more source
Guideline Adherence of Asymptomatic Bacteriuria Management Among Physicians in Jordan: A Cross-sectional Study. [PDF]
Allan H +3 more
europepmc +1 more source
Dissemination and implementation of the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines for allergic rhinitis in general and specialist practice [PDF]
Van Hoecke, Helen
core
A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol +18 more
wiley +1 more source
Tuberculosis contact investigation: an evaluation of yield and guideline adherence, Upper Bavaria, Germany, 2018 to 2022. [PDF]
van de Berg S +6 more
europepmc +1 more source
A new class of biohybrid spheroids is engineered through the self‐assembly of adherent cells and extracellular matrix‐mimetic hydrogel microparticles (microgels). By mimicking a snowballing effect, this approach enables scalable formation of porous, millimeter‐scale spheroids with enhanced cell viability and molecular diffusion.
Zaman Ataie +7 more
wiley +1 more source
Association between pharmacological guideline adherence and actigraphy-measured sleep variables in long-term hospitalized patients with schizophrenia. [PDF]
Saito K +11 more
europepmc +1 more source
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao +11 more
wiley +1 more source
Guideline adherence in surgical decisions for T1 colorectal cancer after endoscopic resection: large language models vs clinicians. [PDF]
Zeng L +5 more
europepmc +1 more source

