Results 161 to 170 of about 36,942 (288)

AKR1C3 Binds β‐Trcp to Promote the Degradation of TFRC to Protect Hepatocellular Carcinoma From Ferroptosis

Cancer Science, EarlyView.
In this study, we show that aldo‐keto reductase family 1 member C3 (AKR1C3), a protein highly expressed in ferroptosis resistant hepatocellular carcinoma cells, acts as an enzyme‐independent scaffold protein by promoting the nuclear export of β‐transducin repeat protein (β‐TrCP) and its binding to transferrin receptor (TFRC) in an enzyme‐independent ...
Lei Qi, Jingyi Hua, Di Pan, Wanwan Yang, Geng Tian, Fangyu Ye, Lingxiang Liu, Yuhan Mao, Qinglong Guo, Haopeng Sun, Li Zhao   +10 more
wiley   +1 more source

<i>Carya luodianensis</i> (Juglandaceae), a New Species From Guizhou Province, Southern China, Revealed by Morphological and Plastid Evidence. [PDF]

Ecol Evol
Yang YB, Yang CY, Yao WH, Yang B, Huang L, An MT, Jiang GB, Luo H, Li H.   +8 more
europepmc   +1 more source

Listening to Children's Need to Matter in Skipped Generation Migrant Households: A Study in Rural Hunan, China

Child &Family Social Work, EarlyView.
ABSTRACT This article explores the experiences of children who live in skipped generation households because of parental migration. Drawing on our matched interviews with 34 children and 20 grandparents from 19 skipped generation households in rural Hunan, central China, we examine what the children wanted significant adults to know about their care ...
Rachel Murphy, Li Mi, Xiaoyan Huang
wiley   +1 more source

Three new species of <i>Ochrolechia</i> (Ochrolechiaceae, Pertusariales) from Guizhou Province, China. [PDF]

MycoKeys
Zheng W, He L, Bo H, Jeewon R, Jayawardena RS, Wang Y, Wang J, Fu S, Meng Q.   +8 more
europepmc   +1 more source

SCD2 Alleviates Diabetes‐Associated Cognitive Dysfunction by Improving Microglial Lipid Metabolism

Cell Proliferation, EarlyView.
This study reveals a novel mechanism of microglial metabolic dysfunction in diabetic cognitive impairment. Defective SCD2 disrupts monounsaturated fatty acid (MUFA) metabolism, triggering mitochondrial oxidative phosphorylation dysfunction and leading to abnormal lipid droplet accumulation (marked by PLIN2).
Yang Yang, Juan He, Jing Zheng, Bing Shao, Lixin Shi, Miao Zhang   +5 more
wiley   +1 more source

Feedback Intervention for the Control of Glucocorticoid Prescription in Primary Care Institutions: A Cluster Randomized Cross-Over Controlled Trial in Southwest China

Risk Management and Healthcare Policy
Ling Liu,1,* Lei Wang,2,* Hanni Zhou,3,4 Junli Yang,3 Wenju Wang,1 Xiaobo Luo,1 Yue Chang3,4,* 1School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical ...
Liu L, Wang L, Zhou H, Yang J, Wang W, Luo X, Chang Y   +6 more
doaj  

Osteology and phylogeny of <i>Panzhousaurus rotundirostris</i> from the Middle Triassic (Anisian) of Guizhou Province, China, and implications for the origin of Keichousauridae (Pachypleurosauroidea, Eosauropterygia). [PDF]

PeerJ
Tan FT, Xu GH, Shang QH.
europepmc   +1 more source

A Curcumin‐Derived HSP70 Inhibitor Disrupts Lysosomal Function to Suppress Triple‐Negative Breast Cancer Progression

Cell Proliferation, EarlyView.
Novel curcumin‐derived M4 binds HSP70's ATPase domain, disrupting HSP70‐mediated lysosomes‐autophagy pathway to inhibit TNBC growth and metastasis, and synergizes with paclitaxel for potent combination therapy. ABSTRACT Structural modification of curcumin yielded a novel series of 1,4‐pentadien‐3‐one oxime ether derivatives, among which compound M4 ...
Zijian Li, Wanxia Wang, Yuxin Zhou, Tao Zeng, Jian Liu, Yingjie Qing, Xuan Han   +6 more
wiley   +1 more source

Analysis of Spatiotemporal Evolution Characteristics and Driving Factors of NPP in Guizhou Province, China. [PDF]

Ecol Evol
Xie B, Liu Y, Fan H, Zhang M.
europepmc   +1 more source

Rhododendron diversity patterns provide new insights for conserving China's montane flora

Journal of Integrative Plant Biology, EarlyView.
Integrating distribution, phylogenetic, and functional trait data for 603 Rhododendron species in China identified significant conservation hotspots of multidimensional diversity, particularly in the Hengduan Mountains. Climate seasonality and topographic heterogeneity jointly influenced these patterns; however, notable conservation gaps remained ...
Ming‐Shu Zhu, Zhi‐Qiong Mo, Ya‐Yuang Luo, Chao‐Nan Fu, Ting Zhang, Michael Möller, Jie Cai, Wei Zheng, De‐Zhu Li, Lian‐Ming Gao   +9 more
wiley   +1 more source