Results 31 to 40 of about 9,618 (261)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Increased brain white matter axial diffusivity associated with fatigue, pain and hyperalgesia in Gulf War illness.

PLoS ONE, 2013
BackgroundGulf War exposures in 1990 and 1991 have caused 25% to 30% of deployed personnel to develop a syndrome of chronic fatigue, pain, hyperalgesia, cognitive and affective dysfunction.MethodsGulf War veterans (n = 31) and sedentary veteran and ...
Rakib U Rayhan, Benson W Stevens, Christian R Timbol, Oluwatoyin Adewuyi, Brian Walitt, John W VanMeter, James N Baraniuk   +6 more
doaj   +1 more source

Self-reported ill health in male UK Gulf War veterans: a retrospective cohort study

BMC Public Health, 2004
Background Forces deployed to the first Gulf War report more ill health than veterans who did not serve there. Many studies of post-Gulf morbidity are based on relatively small sample sizes and selection bias is often a concern.
Doyle Pat, Maconochie Noreen, Simmons Rebecca   +2 more
doaj   +1 more source

Restoring tripartite glutamatergic synapses: A potential therapy for mood and cognitive deficits in Gulf War illness

Neurobiology of Stress, 2020
Gulf War illness is associated with a combination of exposure to war-related chemical agents and traumatic stress. Currently, there are no effective treatments, and the pathophysiology remains elusive.
Xueqin Wang, Zan Xu, Fangli Zhao, Kuanhung J. Lin, Joshua B. Foster, Tianqi Xiao, Nydia Kung, Candice C. Askwith, John P. Bruno, Valentina Valentini, Kevin J. Hodgetts, Chien-liang Glenn Lin   +11 more
doaj   +1 more source

Geopolitical factors affecting childhood nutrition: Iraqi case

مجلة كلية الطب, 2021
In Iraq, child’s health had been deteriorated over three turbulent decades starting from the huge and rapid degradation of the country infrastructure by Iraq –Iran war (1980-1988), Gulf War in 1991, and economic sanction.
Huda Sabah Al-Jadiri, Besmah M. Ali, Jawad K. Al-Diwan   +2 more
doaj   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Progression of intervention-focused research for Gulf War illness

Military Medical Research, 2019
The Persian Gulf War of 1990 to 1991 involved the deployment of nearly 700,000 American troops to the Middle East. Deployment-related exposures to toxic substances such as pesticides, nerve agents, pyridostigmine bromide (PB), smoke from burning oil ...
Jeremy E. Chester, Mazhgan Rowneki, William Van Doren, Drew A. Helmer   +3 more
doaj   +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source

Association of deployment characteristics and exposures with persistent ill health among 1990-1991 Gulf War veterans in the VA Million Veteran Program

Environmental Health
Background Veterans of the 1990–1991 Gulf War have experienced excess health problems, most prominently the multisymptom condition Gulf War illness (GWI).
Lea Steele, Rachel Quaden, Sarah T. Ahmed, Kelly M. Harrington, Linh M. Duong, John Ko, Elizabeth J. Gifford, Renato Polimanti, J. Michael Gaziano, Mihaela Aslan, Drew A. Helmer, Elizabeth R. Hauser, on behalf of the Department of Veterans Affairs Cooperative Studies Program #2006 and the VA Million Veteran Program   +12 more
doaj   +1 more source