Results 11 to 20 of about 7,383 (189)

Reuniting philosophy and science to advance cancer research. [PDF]

Biol Rev Camb Philos Soc, 2023
ABSTRACT Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework,
Pradeu T, Daignan-Fornier B, Ewald A, Germain PL, Okasha S, Plutynski A, Benzekry S, Bertolaso M, Bissell M, Brown JS, Chin-Yee B, Chin-Yee I, Clevers H, Cognet L, Darrason M, Farge E, Feunteun J, Galon J, Giroux E, Green S, Gross F, Jaulin F, Knight R, Laconi E, Larmonier N, Maley C, Mantovani A, Moreau V, Nassoy P, Rondeau E, Santamaria D, Sawai CM, Seluanov A, Sepich-Poore GD, Sisirak V, Solary E, Yvonnet S, Laplane L.   +37 more
europepmc   +2 more sources

Distribution reappraisal of peripheral T- and NK-cell lymphoma entities through the French Lymphopath network database. [PDF]

Hemasphere
HemaSphere, Volume 9, Issue 7, July 2025.
Grange T, Poullot E, Parrens M, Traverse-Glehen A, Syrykh C, Xerri L, Bruneau J, Fataccioli V, Amara N, Dubois R, Moreau A, Nicolae A, Drieux F, Lacheretz-Szablewski V, Llamas-Gutierrez F, Ledoux-Pilon A, Copin MC, Chassagne-Clément C, Lemonnier F, Brousset P, Gaulard P.   +20 more
europepmc   +2 more sources

Isatuximab in combination with cemiplimab in patients with relapsed/refractory multiple myeloma: A phase 1/2 study. [PDF]

Cancer Med, 2023
Preclinical data suggest that concurrent treatment of anti‐CD38 and anti‐PD‐1/PD‐L1 antibodies can substantially reduce primary tumor growth by reversing T‐cell exhaustion, and thus may synergize with anti‐PD‐1/PD‐L1 treatment. This Phase 1/2 trial was designed to determine whether cemiplimab (anti‐PD‐1) enhances the anti‐myeloma activity of isatuximab
Lesokhin A, LeBlanc R, Dimopoulos MA, Capra M, Carlo-Stella C, Karlin L, Castilloux JF, Forsberg P, Parmar G, Tosikyan A, Pour L, Ribrag V, Ribolla R, Abdallah AO, Le Roux N, Dong L, van de Velde H, Mayrargue L, Lépine L, Macé S, Moreau P.   +20 more
europepmc   +2 more sources

P1079: VERY LONG-TERM FOLLOW-UP OF RITUXIMAB MAINTENANCE IN YOUNG PATIENTS WITH MANTLE CELL LYMPHOMA INCLUDED IN THE LYMA TRIAL, A LYSA STUDY. [PDF]

Hemasphere, 2023
HemaSphere, Volume 7, Issue S3, August 2023.
Sarkozy C, Thieblemont C, Oberic L, Moreau A, Bouabdallah K, Laurent Damaj G, Gastinne T, Ribrag V, Olivier Casasnovas R, Haioun C, Houot R, Jardin F, Neste E, Cheminant M, Morschhauser F, Callanan M, Ghesquieres H, Gressin R, Hermine O, Le Gouill S.   +19 more
europepmc   +2 more sources

High plasma concentrations of acyl-coenzyme A binding protein (ACBP) predispose to cardiovascular disease: Evidence for a phylogenetically conserved proaging function of ACBP. [PDF]

Aging Cell, 2023
Montegut et al. provide evidence in favor of a proaging function of acyl CoA binding protein (ACBP) across multiple systems: yeast, mice and humans with cardiovascular disease. Abstract Autophagy defects accelerate aging, while stimulation of autophagy decelerates aging.
Montégut L, Joseph A, Chen H, Abdellatif M, Ruckenstuhl C, Motiño O, Lambertucci F, Anagnostopoulos G, Lachkar S, Dichtinger S, Maiuri MC, Goldwasser F, Blanchet B, Fumeron F, Martins I, Madeo F, Kroemer G.   +16 more
europepmc   +2 more sources

Phase I study of plitidepsin in combination with bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma. [PDF]

Cancer Med, 2023
This phase I trial evaluated antitumor activity for plitidepsin plus bortezomib (BTZ) and dexamethasone (DXM) in relapsed/refractory multiple mieloma patients (r/r MM). This triple combination of plitidepsin, BTZ, and DXM showed an acceptable safety profile and had moderate activity in adult patients with r/r MM that have failed to standard common ...
Mateos MV, Prosper F, Martin Sánchez J, Ocio EM, Oriol A, Motlló C, Michot JM, Jarque I, Iglesias R, Solé M, Martínez S, Kahatt C, Fudio S, Corral G, Zeaiter A, Montilla L, Ribrag V.   +16 more
europepmc   +2 more sources

Encountering Spiking Neural Networks

Visual Anthropology Review, Volume 39, Issue 2, Page 476-495, Fall 2023., 2023
Abstract Over the past two decades, the term “intelligent media” has surfaced to describe media that take on problematics of cognition, communication, and sensory perception loosely modeled after human intelligence. Taking the form of hardware‐software assemblages, these novel media demonstrate forms of autonomy that challenge human control and herald ...
Alexandre Saunier, David Howes
wiley   +1 more source

Deciphering the Whisper of Volcanoes: Monitoring Velocity Changes at Kamchatka's Klyuchevskoy Group With Fluctuating Noise Fields

Journal of Geophysical Research: Solid Earth, Volume 128, Issue 4, April 2023., 2023
Abstract Volcanic inflation and deflation often precede eruptions and can lead to seismic velocity changes () in the subsurface. Recently, interferometry on the coda of ambient noise‐cross‐correlation functions yielded encouraging results in detecting these changes at active volcanoes. Here, we analyze seismic data recorded at the Klyuchevskoy Volcanic
Peter Makus, Christoph Sens‐Schönfelder, Luc Illien, Thomas R. Walter, Alexander Yates, Frederik Tilmann   +5 more
wiley   +1 more source

Repeating Low Frequency Icequakes in the Mont‐Blanc Massif Triggered by Snowfalls

Journal of Geophysical Research: Earth Surface, Volume 127, Issue 12, December 2022., 2022
Abstract Deformation mechanisms of glaciers are highly sensitive to basal temperature; the motion of temperate glaciers is dominated by basal slip while cold‐based glaciers deform mainly by internal creep. While basal slip is usually aseismic, unstable slip sometimes occurs and can be detected by seismometers.
Agnès Helmstetter
wiley   +1 more source

Geophysical monitoring of a laboratory‐scale internal erosion experiment

Near Surface Geophysics, Volume 20, Issue 4, Page 365-383, August 2022., 2022
ABSTRACT Earth dams are structures used worldwide for water management. Their failure over time is notably due to water seepage generating internal erosion. There is a growing need to detect the processes at work as early as possible. This study presents a controlled laboratory experiment aimed at detecting and monitoring water seepage into a soil ...
Yara Maalouf, Grégory Bièvre, Christophe Voisin, Naji Khoury   +3 more
wiley   +1 more source