Results 141 to 150 of about 2,342,108 (381)

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

Thiamine Acquisition Strategies Impact Metabolism and Competition in the Gut Microbe Bacteroides thetaiotaomicron. [PDF]

open access: yes, 2017
Thiamine (vitamin B1) is an essential cofactor for all organisms. Humans primarily acquire thiamine through their diet, and thiamine deficiencies have adverse neurological effects.
Costliow, Zachary A, Degnan, Patrick H
core  

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

open access: yesFEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp   +13 more
wiley   +1 more source

Gauge Coupling Unification in Heterotic String Models with Gauge Mediated SUSY Breaking

open access: yes, 2011
We calculate the weak scale MSSM spectrum starting from a heterotic string theory compactified on an anisotropic orbifold. Supersymmetry breaking is mediated by vector-like exotics that arise naturally in heterotic string theories.
Anandakrishnan, Archana, Raby, Stuart
core   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

open access: yesFEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori   +8 more
wiley   +1 more source

Fregego krytyka dowodu ontologicznego (FREGE'S CRITICISM OF THE ONTOLOGICAL ARGUMENT) [PDF]

open access: yesAnaliza i Egzystencja, 2005
The paper reconstructs Frege's criticism of the ontological argument for the existence of God on the basis of various remarks scattered in his writings.
Arkadiusz Gut
doaj  

F-Theory GUT Vacua on Compact Calabi-Yau Fourfolds

open access: yes, 2009
We present compact three-generation F-theory GUT models meeting in particular the constraints of D3-tadpole cancellation and D-term supersymmetry. To this end we explicitly construct elliptically fibered Calabi-Yau fourfolds as complete intersections in ...
A Collinucci   +54 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Zagadnienie wolności osoby ludzkiej w ujęciu Leibniza (THE PROBLEM OF HUMAN FREEDOM ACCORDING TO LEIBNIZ) [PDF]

open access: yesAnaliza i Egzystencja, 2005
The article concerns the fundamental metaphysical problem of human freedom as it is discussed in Leibniz's philosophy. The essence of it can be expressed as follows: in what way the determinism developed by Leibniz goes along with his doctrine of human ...
Przemysław Gut
doaj  

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