Results 171 to 180 of about 260,831 (351)

Pan‐cancer analysis shapes the understanding of cancer biology and medicine

Cancer Communications, EarlyView.
Abstract Advances in multi‐omics datasets and analytical methods have revolutionized cancer research, offering a comprehensive, pan‐cancer perspective. Pan‐cancer studies identify shared mechanisms and unique traits across different cancer types, which are reshaping diagnostic and treatment strategies.
Xiaoping Cen, Yuanyuan Lan, Jiansheng Zou, Ruilin Chen, Can Hu, Yahan Tong, Chen Zhang, Jingyue Chen, Yuanmei Wang, Run Zhou, Weiwei He, Tianyu Lu, Fred Dubee, Dragomirka Jovic, Wei Dong, Qingqing Gao, Man Ma, Youyong Lu, Yu Xue, Xiangdong Cheng, Yixue Li, Huanming Yang   +21 more
wiley   +1 more source

A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation

Hepatology, EarlyView., 2022
In this study of the gut mucosal microbiota in primary sclerosing cholangitis (PSC), we found consistent microbiota features associated with PSC and recurrent PSC, PSC with inflammatory bowel disease and a persistent gut dysbiosis after liver transplantation Abstract Background and Aims Several characteristic features of the fecal microbiota have been ...
Mikal Jacob Hole, Kristin Kaasen Jørgensen, Kristian Holm, Peder R. Braadland, Malin Holm Meyer‐Myklestad, Asle Wilhelm Medhus, Dag Henrik Reikvam, Alexandra Götz, Krzysztof Grzyb, Kirsten Muri Boberg, Tom Hemming Karlsen, Martin Kummen, Johannes R. Hov   +12 more
wiley   +1 more source

The Macaque Gut Microbiome in Health, Lentiviral Infection, and Chronic Enterocolitis

, 2008
Philip M. McKenna, Christian Hoffmann, Nana Minkah, Pyone P. Aye, Andrew A. Lackner, Zongzhi Liu, Catherine Lozupone, Micah Hamady, Rob Knight, Frederic D. Bushman   +9 more
openalex   +2 more sources

The Role of Five‐Membered Aromatic Rings Containing N and O in Modulating Bile Acid Receptors: An Overview

ChemMedChem, Accepted Article.
Over the past decades extensive scientific research in the fields of chemistry and pharmaceutical chemistry has led to the synthesis and study of numerous chemical compounds with diverse therapeutic applications. Many of these compounds feature heterocyclic aromatic structures, including six‐, five‐, and four‐membered rings.
Claudia Finamore, Carmen Festa, Rosa Barbato, Stefano Fiorucci, Angela Zampella, Simona De Marino   +5 more
wiley   +1 more source

Microbiome‐Informed Dosing: Exploring Gut Microbial Communities Impact on Mycophenolate Enterohepatic Circulation and Therapeutic Target Achievement

Clinical Pharmacology &Therapeutics, EarlyView.
Pharmacomicrobiomics is an emerging field due to important microbiome effects on pharmacokinetics and clinical outcomes. However, the application of this knowledge remains limited. Mycophenolic acid (MPA) is the primary active metabolite of the immunosuppressant, mycophenolate mofetil (MMF).
Abdelrahman Saqr, Shen Cheng, Mahmoud Al‐Kofahi, Christopher Staley, Pamala A. Jacobson   +4 more
wiley   +1 more source

Antibiotic‐Induced Microbial Dysbiosis Worsened Outcomes in the Activity‐Based Anorexia Model

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a complex psychiatric disorder characterized by persistent dieting and reduced food intake, leading to significantly low body weight. Dysbiosis in the gut microbiome of patients with AN has been suggested to contribute to the pathogenesis.
Karlijn L. Kooij, Nadia Andrea Andreani, Lara Keller, Stefanie Trinh, Luna van der Gun, Jamie Hak, Keith Garner, Mieneke Luijendijk, Lisa Drost, Unna Danner, Annemarie van Elburg, Astrid Dempfle, Jochen Seitz, Beate Herpertz‐Dahlmann, John F. Baines, Roger A. H. Adan   +15 more
wiley   +1 more source

Collateral effects of antibiotics on mammalian gut microbiomes [PDF]

, 2012
Torey Looft, Heather K. Allen
openalex   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Succession of microbial consortia in the developing infant gut microbiome

, 2010
Jeremy E. Koenig, Aymé Spor, Nicholas B. Scalfone, Ashwana D. Fricker, Jesse Stombaugh, Rob Knight, Largus T. Angenent, Ruth E. Ley   +7 more
openalex   +1 more source

Stabilization of the murine gut microbiome following weaning [PDF]

, 2012
Patrick D. Schloss, Alyxandria M. Schubert, Joseph P. Zackular, Kathryn Iverson, Vincent B. Young, Joseph F. Petrosino   +5 more
openalex   +1 more source