Results 191 to 200 of about 896,723 (386)

Covalent Organic Frameworks‐Delivered Reuterin Drives Trained Immunity in Tumor‐Associated Macrophages to Enhance Melanoma Immunotherapy via Glycerophospholipid Metabolism

Advanced Science, EarlyView.
Covalent organic framework (COF)‐reuterin induces trained immunity in tumor‐associated macrophages, promoting the generation of nitric oxide and reactive oxygen species, thereby enhancing the antitumor immune response. Additionally, COF‐Reuterin directly kills tumor cells while simultaneously eradicating pathogenic intratumoural bacteria.
Jian‐Gang Zhang, Xiao‐Mei Zhang, Xi Wu, Cheng‐Kai Zhou, Zhen‐Zhen Liu, Xue‐Yue Luo, Liang Zhang, Wei Chen, Yong‐Jun Yang   +8 more
wiley   +1 more source

Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinflammation in a food-borne polystyrene microplastic exposed mouse model

Journal of Neuroinflammation
The impact of polystyrene microplastics (PS-MPs) on the nervous system has been documented in the literature. Numerous studies have demonstrated that the activation of the epidermal growth factor receptor 4 (ErbB4) is crucial in neuronal injury and ...
Chong Liu, Yan Zhao, Wei Zhang, Ji-Ji Dao, Qian Li, Jia Huang, Zhen-Feng Li, Yu-Ke Ma, Chen-Meng Qiao, Chun Cui, Shuang-Xi Chen, Li Yu, Yan-Qin Shen, Wei-Jiang Zhao   +13 more
doaj   +1 more source

Aqueous extract of Saposhnikovia divaricata root alleviates rheumatoid arthritis by acting on TNF-α and RAGE signaling pathways

Biochemistry and Biophysics Reports
Saposhnikovia divaricata (Turcz.) Schisch (SADS) is classified as a special-grade traditional Chinese medicine in Shennong's Materia Medical due to its immune-protective effects, including dispelling cold, relieving edema and pain, and its potential in ...
Anjing Xu, Yuanyuan Wen, Bao Hou, Shijie Zhang, Tsedien Nhamdriel, Xiaoyue Ma, Liyuan Cui, Xuexue Zhu, Weiwei Cai, Liying Qiu, Haijian Sun   +10 more
doaj   +1 more source

Gut microbiota: a potential new territory for drug targeting [PDF]

, 2008
Wei Jia, Houkai Li, Liping Zhao, Jeremy K. Nicholson   +3 more
openalex   +1 more source

Commensal Viruses Promote Intestinal Stem Cell Regeneration Following Radiation Damage by Inhibiting Hyperactivation of RIG‐I and Notch Signals

Advanced Science, EarlyView.
Ionizing radiation disrupts gut virome and bacteriome. Gut commensal viruses protect against intestinal damage and promote stem cell regeneration by inhibiting hyperactivation of RIG‐I and Notch signaling in stem cells. Fecal virome transplantation (FVT) from healthy donors can serve as a potential therapeutic intervention by enriching phages targeting
Xiaotong Zhao, Yu Cai, Yujia Hou, Yanjin Wu, Tingting Wei, Lili Li, Zhaojun Duan, Xinran Lu, Jiahui Meng, Haitao Zhou, Qin Wang, Jinhan Wang, Chang Xu, Liqing Du, Saijun Fan, Feng Wang, Qiang Liu, Yang Liu   +17 more
wiley   +1 more source

Lactobacillus rhamnosus GG triggers intestinal epithelium injury in zebrafish revealing host dependent beneficial effects

iMeta
Lactobacillus rhamnosus GG (LGG), the well‐characterized human‐derived probiotic strain, possesses excellent properties in the maintenance of intestinal homeostasis, immunoregulation and defense against gastrointestinal pathogens in mammals.
Zhen Zhang, Hong‐Ling Zhang, Da‐Hai Yang, Qiang Hao, Hong‐Wei Yang, De‐Long Meng, Willem Meindert de Vos, Le‐Luo Guan, Shu‐Bin Liu, Tsegay Teame, Chen‐Chen Gao, Chao Ran, Ya‐Lin Yang, Yuan‐Yuan Yao, Qian‐Wen Ding, Zhi‐Gang Zhou   +15 more
doaj   +1 more source

Suppressed oncogenic molecules involved in the treatment of colorectal cancer by fecal microbiota transplantation

Frontiers in Microbiology
Dysbiosis of the intestinal microbiota is prevalent among patients with colorectal cancer (CRC). This study aims to explore the anticancer roles of the fecal microbiota in inhibiting the progression of colorectal cancer and possible mechanisms.
Xing Han, Xing Han, Xing Han, Bo-Wen Zhang, Bo-Wen Zhang, Bo-Wen Zhang, Wei Zeng, Meng-Lin Ma, Ke-Xin Wang, Bao-Juan Yuan, Bao-Juan Yuan, Bao-Juan Yuan, Dan-Qi Xu, Dan-Qi Xu, Dan-Qi Xu, Jia-Xin Geng, Jia-Xin Geng, Jia-Xin Geng, Chao-Yuan Fan, Chao-Yuan Fan, Chao-Yuan Fan, Zhan-Kui Gao, Zhan-Kui Gao, Zhan-Kui Gao, Muhammad Arshad, Muhammad Arshad, Muhammad Arshad, Shan Gao, Liangliang Zhao, Shu-Lin Liu, Shu-Lin Liu, Shu-Lin Liu, Shu-Lin Liu, Shu-Lin Liu, Xiao-Qin Mu, Xiao-Qin Mu, Xiao-Qin Mu, Xiao-Qin Mu   +37 more
doaj   +1 more source

Gut microbiota and pregnancy, a matter of inner life [PDF]

, 2008
Patrice D. Cani
openalex   +1 more source

Megasphaera Elesdenii Dysregulates Colon Epithelial Homeostasis, Aggravates Colitis‐Associated Tumorigenesis

Advanced Science, EarlyView.
A fecal microbial meta‐analysis reveals that Megasphaera is highly abundant in the Asian population with IBD and CRC. M. elsdenii reshapes colonic immunity by triggering DC cell‐mediated Th1 and Th17 inflammation. M. elsdenii and M. elsdenii‐enriched microbiota exacerbate colonic inflammation and tumorigenesis in AOM/DSS mice.
Xinxin Hou, Zhaozhou Zhang, Wanqing Chen, Jinming Li, Xiangxiang Zhu, Mingjie Li, Xiaoqi Guan, Haidong Guo, Yanlei Ma, Ling Zhao   +9 more
wiley   +1 more source

Akkermansia muciniphila‐Derived N‐Acetylspermidine Modulates the Localization of Intestinal α1,2‐Fucosylated Proteins to Maintain Gut Homeostasis

Advanced Science, EarlyView.
This study demonstrates that Akkermansia muciniphila alleviates colitis by enhancing intestinal α1,2‐fucosylation through its metabolite N‐acetylspermidine. Mechanistically, N‐acetylspermidine‐induced PIM1 inhibition promotes HDAC2‐mediated reduction of chromatin accessibility at TP73, thereby upregulating C1GALT1C1 to boost α1,2‐fucosylation.
Ye Yao, Zhangming Pei, Yuanyuan Dai, Yinghan Chen, Zepeng Chang, Hongchao Wang, Jianxin Zhao, Hao Zhang, Qixiao Zhai, Wenwei Lu, Wei Chen   +10 more
wiley   +1 more source