Results 201 to 210 of about 423,623 (239)

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

Disseminated Histoplasmosis and Aortic Valve Infective Endocarditis in a Patient With Recent Aortobifemoral Bypass. [PDF]

Am J Case Rep
Behjatnia H, Couto P, Castillo Y, Dominguez L, Carlan S, Guzman TH, Jentoft ME.   +6 more
europepmc   +1 more source

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

Brain Pathology, EarlyView.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla   +20 more
wiley   +1 more source

Researcher awareness and submission practices to ethics committees in Saudi Arabia: a cross-sectional study. [PDF]

BMC Med Ethics
Bogdadi RS, Qushmaq DNA, Al Hasheem ER, De Guzman DMM, Baeshen WA, Aljeaid SM.   +5 more
europepmc   +1 more source

Dissociating role of Bassoon in glutamatergic and dopaminergic neurons in alcohol‐related behaviour and affective state in mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Alcohol abuse and affective disorders are severe comorbid psychiatric diseases characterized by impaired brain synaptic transmission. The role of presynaptic scaffolding proteins coordinating presynaptic plasticity and neurotransmitter release, such as Bassoon (Bsn), in the pathogenesis of these disorders remains elusive.
Liubov S. Kalinichenko, Mona Krenbauer, Janosh Isert, Marlon Kamlah, Thorben Tanzer, Hannes Rödel, Tobias Müller, Anil Annamneedi, Enes Yağız Akdaş, Volker Eulenburg, Bernd Lenz, Eckart D. Gundelfinger, Johannes Kornhuber, Anna Fejtova, Christian P. Müller   +14 more
wiley   +1 more source

Manoeuvring Among Institutions and Pandemic Restrictions: When the Fantasy of Parenting After Divorce or Breakup and the Respective Emotions Matter

Child &Family Social Work, EarlyView.
ABSTRACT Understanding social factors that affected how people interpreted the meanings of COVID‐19 measures is important in postpandemic times. This study applies perspectives from research on emotions as one of the possible explanations and focuses on how institutions and their measures are perceived in the context of individual emotional situations.
Eva M. Hejzlarová
wiley   +1 more source

Dynamic radiographic angle changes in planovalgus foot correction among children with cerebral palsy. [PDF]

Arch Orthop Trauma Surg
Arenas-Díaz AL, Barajas-Monterrey A, Fuentes-Figueroa S, Barrón-Torres EA, Hernández-Gómez C, Guzmán-Martín CA.   +5 more
europepmc   +1 more source

Client‐Perpetrated Violence and Intent to Leave Among Child Welfare Workers: A Three‐Wave Cross‐Lagged Prospective Study of Causal Directions and the Role of Work‐Related Worrying

Child &Family Social Work, EarlyView.
ABSTRACT Client‐perpetrated violence and turnover intentions are widespread problems among child‐welfare workers and are associated with both personal and organizational consequences. To elucidate their longitudinal association, the current study built on the cognitive activation theory of stress (CATS) and investigated (H1) whether client‐perpetrated ...
Sana Parveen, Live Bakke Finne, Silje Endresen Reme, Morten Birkeland Nielsen   +3 more
wiley   +1 more source

Clinical, Histopathological, and Molecular Prognostic Factors Associated With Survival and Disease Progression in Adult Patients With Primary and Secondary Thyroid Lymphomas: Scoping Review Protocol.

JMIR Res Protoc
Lemos-Rodriguez AM, Lenis-Gonzalez JP, Arias-Valderrama O, Arrieta E, Guzman GE, Garcia AO.   +5 more
europepmc   +1 more source

Pemphigus herpetiformis: A case report of response to dupilumab after failure of multiple conventional therapies. [PDF]

JAAD Case Rep
Pabón-González F, Jiménez-Sacarello I, Cuesta-Camuñas J, Nevarez-Pomales O, García-Guzmán LG, Medina-Figueroa M.   +5 more
europepmc   +1 more source