Results 301 to 310 of about 283,327 (339)

Polygenic Risk for Pre‐Eclampsia and the Long‐Term Risk of Incident Hypertension and Cardiovascular Disease: A Population‐Based Cohort Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To investigate whether genetic predisposition to pre‐eclampsia (PE), measured by a polygenic risk score (PRS), is associated with incident hypertension and cardiovascular disease (CVD) after delivery in Asian women. Design Prospective population‐based cohort study.
Eun‐Saem Choi, Sang‐Hyuk Jung, Young Mi Jung, Chan‐Wook Park, Joong Shin Park, Jong Kwan Jun, Jaeyoung Kim, Beomsu Kim, Chamlee Cho, Injeong Shim, Dokyoon Kim, Hong‐Hee Won, Seung Mi Lee   +12 more
wiley   +1 more source

Genome Selection for Fleece Traits in Inner Mongolia Cashmere Goats Based on GWAS Prior Marker Information. [PDF]

Animals (Basel)
Yao H, Wang N, Li Y, He G, Ning J, Kang S, Liu Y, Li J, Lv Q, Wang R, Zhang Y, Su R, Wang Z.   +12 more
europepmc   +1 more source

Phosphodiesterase‐5 Inhibition and Alzheimer's Disease Risk: A Mendelian Randomisation Study

Aging Cell, EarlyView.
Preclinical studies suggest PDE5 inhibitors may improve cognition, but observational evidence on Alzheimer's disease (AD) risk is mixed. We performed a cis‐Mendelian randomisation analysis across four AD genome‐wide association studies (GWAS) datasets and a sex‐stratified analysis using UK Biobank data.
Marta Alcalde‐Herraiz, Benjamin Woolf, Junqing Xie, Emma Anderson, Dipender Gill, Ioanna Tzoulaki, Laura M. Winchester, James Yarmolinsky, Daniel Prieto‐Alhambra, Danielle Newby   +9 more
wiley   +1 more source

Unsupervised feature extraction using deep learning empowers discovery of genetic determinants of the electrocardiogram. [PDF]

Genome Med
Sieliwonczyk E, Sau A, Patlatzoglou K, McGurk KA, Pastika L, Thami PK, Mangino M, Zheng SL, Powell G, Curran L, Buchan RJ, Theotokis P, Peters NS, Loeys B, Kramer DB, Waks JW, Ng FS, Ware JS.   +17 more
europepmc   +1 more source

Association of Epigenetic Age Acceleration and Mitochondrial DNA‐Based Aging Metrics Provides Insights Into Mechanisms of Aging‐Related Diseases

Aging Cell, EarlyView.
Older participants exhibit lower mtDNA copy number (CN) and a higher rare heteroplasmy burden, while common heteroplasmy burden remains relatively stable. Higher epigenetic age acceleration is associated with lower mtDNA CN and higher rare heteroplasmy burden in 6316 participants.
Mengyao Wang, Yinan Zheng, Meng Lai, Emmanuel Saake, Xue Liu, Xiuqing Guo, Kent D. Taylor, Tianxiao Huan, Roby Joehanes, Drew R. Nannini, Kai Zhang, Nicole J. Lake, Christina A. Castellani, Stephen S. Rich, Jerome I. Rotter, Yongmei Liu, Laura M. Raffield, April P. Carson, Myriam Fornage, Jiantao Ma, Dan E. Arking, Lifang Hou, Daniel Levy, Chunyu Liu   +23 more
wiley   +1 more source

Relationship between childhood obesity and cardiovascular and cerebrovascular diseases: a study based on the combination of multiple databases. [PDF]

BMC Public Health
Chen C, Xie B, Tao F, Chen J, Ye L, Zhong L, Yan S, Cheng W.   +7 more
europepmc   +1 more source

The Roles of EDA2R in Ageing and Disease

Aging Cell, EarlyView.
Elevated expression of the ectodysplasin A2 receptor (EDA2R) has been linked to ageing and disease. We appraise the roles of EDA2R in these processes, exploring mechanisms of action, biomarker potential and therapeutic relevance of EDA2R in multiple contexts. ABSTRACT Ageing is a complex biological process driven, in part, by inflammaging.
Gemma Farrington, Lauren Tonge, Tracy Branagan, Sud Sudirman, Chao Fang, Louis Luk, Serkan Kir, Marco Bolis, Ildus I. Ahmetov, Kehinde Ross   +9 more
wiley   +1 more source

Selective sweeps for mutations increasing height impede identification of causative mutations for fertility and other correlated traits in cattle. [PDF]

Genet Sel Evol
Forutan M, Ross EM, Chamberlain AJ, Fordyce G, Engle BN, Nguyen LT, Hayes BJ.   +6 more
europepmc   +1 more source

PCBP2 Regulates p16INK4a‐Dependent Cellular Senescence in Response to Iron

Aging Cell, EarlyView.
PCBP2 induces cellular senescence by modulating the expression of p16INK4a and CD40 in response to iron. PCBP2 activates p16INK4a via the functional SNP rs1333046 on the atherosclerosis‐associated CDKN2A/B locus. ABSTRACT Recently, we have identified rs1333046 as one of the candidate functional single nucleotide polymorphisms (fSNPs) on the ...
Shaoyang Yan, Lili Lu, Yuwei Wu, Zewen Du, Ebin Johny, Partha Dutta, Gang Li   +6 more
wiley   +1 more source

Genome-wide association study identifies genetic variants associated with single-parity reproductive loss in three commercial pig breeds. [PDF]

BMC Genomics
Mekonnen KT, Lee DH, Beyenssa BC, Son AY, Cho YG, Seo KS.   +5 more
europepmc   +1 more source