Results 91 to 100 of about 176,746 (294)

The Tumor‐to‐Endothelial Transfer of FTO Promotes Vascular Remodeling and Metastasis in Nasopharyngeal Carcinoma

open access: yesAdvanced Science, EarlyView.
Integrated omics analysis of matched primary and liver metastatic NPC tumors reveals a unique NOTCH1+ CSC subpopulation exhibiting enhanced stemness properties and tumorigenic capacity. With in vitro and in vivo assays, exosomal transfer of tumor‐derived FTO from NOTCH1+ cells to the endothelium promotes vascular permeability and metastatic potential ...
Chun Wu   +23 more
wiley   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang   +15 more
wiley   +1 more source

Group visit: Blatant Violation of Patient Rights and a Stigma Attached to Health System Responsiveness

open access: yesHealth Technology Assessment in Action
Objective: Health is the basic and definite right of the human being so we aimed to outline a concern about patient rights of gynecologists. Results and conclusion: Considering the above mentioned facts, “stewardship” function of the health system ...
Javad GhoddoosiNejad   +1 more
doaj  

Endometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol‐Driven WNT7B Suppression

open access: yesAdvanced Science, EarlyView.
This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.
Xintong Li   +12 more
wiley   +1 more source

5‐Hydroxymethylcytosine Dynamics Reveals Coordinated Reprogramming of Parental Genomes and X Chromosome Dosage Balance in Mouse SCNT Embryos

open access: yesAdvanced Science, EarlyView.
Genome‐wide, high‐resolution profiling of hydroxymethylation in mouse SCNT embryos reveals a transient, allele‐symmetric 5hmC reprogramming pattern distinct from natural embryos, with X‐chromosomes and imprinting control regions resistant to proper remodeling.
Zeming Xiang   +9 more
wiley   +1 more source

Demographic, Sociocultural, and Behavioral Predictors of Modern Contraceptive Uptake Among Couples in Northern Ghana [Letter]

open access: yesOpen Access Journal of Contraception
Sabrina Shahid, Mahdi Sadeghi, Yusuf Alghabra Medical Education, King’s College London, London, UKCorrespondence: Mahdi Sadeghi, King’s College London, Guy’s Campus, Great Maze Pond, London, SE1 1UL, UK, Email Mahdi.Sadeghi@kcl.ac ...
Shahid S, Sadeghi M, Alghabra Y
doaj  

Immune Predictors of Radiotherapy Outcomes in Cervical Cancer

open access: yesAdvanced Science, EarlyView.
This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang   +8 more
wiley   +1 more source

Witnesses of Medical Sexism: Representations of Gender in Definitions of Gynaecology

open access: yesRedescriptions
This article presents a feminist critical analysis of institutional definitions of gynaecology in Quebec, Canada. By examining six official definitions, three problematic areas are uncovered: the essentialisation and vagueness of the subject ‘woman’; the
Alexandra Toupin, Roxanne Brousseau
doaj   +1 more source

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