Results 51 to 60 of about 38,450 (324)

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner   +6 more
wiley   +1 more source

Transvaginal mesh in repair of pelvic organs prolapse as a minimally invasive surgical procedure [PDF]

open access: yesVojnosanitetski Pregled, 2011
Background/Aim. Prolapse of genital organs with or without urinary stress incontinention is the most often health problem in the elderly female population tending to increase with ageing.
Argirović Rajka   +5 more
doaj   +1 more source

Intraperitoneal chemotherapy for peritoneal metastases : an expert opinion

open access: yes, 2020
Introduction: The rationale for intraperitoneal (IP) drug delivery for patients with peritoneal metastases (PM) is based on the pharmacokinetic advantage resulting from the peritoneal-plasma barrier, and on the potential to adequately treat small, poorly
Braet, Helena   +4 more
core   +1 more source

Laparoscopy in gynecologic oncology: A review of literature [PDF]

open access: yes, 2013
nem
Golubović Andrija   +2 more
core   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

open access: yesFEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr   +5 more
wiley   +1 more source

Identifying Risk Factors for Complications in Gynecologic Laparoscopic Surgery: A Retrospective Study

open access: yesClinical and Experimental Obstetrics & Gynecology, 2023
Background: This study aimed to investigate the risk factors associated with complications following gynecologic laparoscopic surgery. Methods: A retrospective analysis was conducted on patients who underwent gynecologic laparoscopic surgery at Huazhong ...
Aiwen Le, Yahong Xu, Jinyuan Cui
doaj   +1 more source

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

open access: yesFEBS Open Bio, EarlyView.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson   +5 more
wiley   +1 more source

Perspectives of gynecologic oncology fellowship training and preparedness for practice

open access: yesGynecologic Oncology Reports
We aimed to examine the preparedness of recent gynecologic oncology fellowship graduates for independent practice.We conducted a web-based survey study using REDCap targeting Society of Gynecologic Oncology (SGO) members who graduated gynecologic ...
Nancy T. Nguyen   +5 more
doaj   +1 more source

A Risk-Adjusted Model for Ovarian Cancer Care and Disparities in Access to High-Performing Hospitals. [PDF]

open access: yes, 2020
ObjectiveTo validate the observed/expected ratio for adherence to ovarian cancer treatment guidelines as a risk-adjusted measure of hospital quality care, and to identify patient characteristics associated with disparities in access to high-performing ...
Bristow, Robert E   +4 more
core  

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

open access: yesFEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy