Results 271 to 280 of about 838,521 (380)

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

open access: yesInternational Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner   +7 more
wiley   +1 more source

Genetically determined body mass index is associated with diffuse large B‐cell lymphoma in polygenic and Mendelian randomization analyses

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Obesity has been linked to the risk of non‐Hodgkin lymphoma (NHL), but the evidence remains inconclusive. Here, the authors investigate the possibility of shared genetic risk factors between obesity and four common NHL types. Drawing on data from 8 genome‐wide association studies, they found that a higher genetically determined BMI was ...
Amy Moore   +74 more
wiley   +1 more source

The Fibrosis‐4 score is associated with overall mortality and severe haematological toxicity in older patients with cancer: Analysis of two prospective cohort studies

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Liver function decreases with age, affecting the metabolism of many chemotherapy drugs. For older cancer patients, however, a standardized liver status screening method is lacking. Here, Fibrosis‐4 (FIB‐4) score was investigated for its utility as a non‐invasive method in predicting treatment toxicity and mortality in cancer patients age 70
Victoire de Salins   +14 more
wiley   +1 more source

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