Results 71 to 80 of about 402,905 (265)

NAD+ Metabolism Licenses Zygotic Genome Activation via PARP7‐Mediated ADP‐Ribosylation of UHRF1 in Mouse Early Embryos

Advanced Science, EarlyView.
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao, Ziqi Zhang, Anqi Chen, Yanbo Liu, Yuling Lin, Lina Yu, Ruixin Shi, Aolei Guo, Yan Mao, Ganggui Lou, Chaojun Li, Luhong Wen, Guijun Yan, Haixiang Sun   +13 more
wiley   +1 more source

Giovan Battista Codronchi’s De morbis Veneficis ac Veneficiis (1595). Medicine, Exorcism and Inquisition in Counter-Reformation Italy

Religions, 2019
The physician Giovan Battista Codronchi (1547−1628) is a key figure of sixteenth-century medicine. A study of his main work De morbis veneficis ac veneficiis (1595) and his letters sent to the Congregation of the Index in Rome (1597) can teach us ...
Fabiana Ambrosi
doaj   +1 more source

eEF1G Orchestrates Translation to Ensure Meiotic Progression in Transcriptionally Quiescent Spermatocytes

Advanced Science, EarlyView.
eEF1G supports translation elongation of meiotic mRNAs in transcriptionally quiescent leptotene and zygotene spermatocytes. Its depletion in germ cells causes meiotic arrest at the zygotene stage, with defective homologous synapsis and unstable recombination intermediates.
Jianze Xu, Yuwei Hu, Xukun Lu, Yuling Cai, Tongtong Li, Ming Gao, Jinlong Ma, Yuan Gao, Shangming Liu, Zi‐Jiang Chen, Jing Meng, Hongbin Liu, Xiaohua Jiang   +12 more
wiley   +1 more source

Application of concept of fast track surgery in perioperative nursing of patients with gynecologic laparoscopic surgery

Huli yanjiu, 2018
To probe into the application effect of the concept of in the perioperative nursing of patients with gynecologic laparoscopic surgery.Methods:A total of 198 cases of inpatients who underwent laparoscopic surgery in our hospital from May 2017 to August ...
许淑仙, 李霞, 张建华
doaj  

Ovarian Cancer Diagnosis and Chemoresistance Prediction Model Based on cfRNA Molecular Signature

Advanced Science, EarlyView.
A deep learning model analyzes cfRNA profiles extracted from the blood of OVCA patients. This innovative approach distinguishes OVCA from healthy controls with high accuracy. Crucially, it reliably predicts patient response to chemotherapy (sensitive versus resistant subgroups).
Qinhao Guo, Yangyang Zhang, Yongcheng Jin, Siwei Deng, Yongqi Chen, Zheng Feng, Hao Wen, Liu Wang, Yilin Li, Fanghong Ou, Yong Shen, Haiming Li, Tianyao Zhou, Xingzhu Ju, Xiaohua Wu   +14 more
wiley   +1 more source

Häufigkeit von sexuell übertragbaren Infektionen in deutschen Facharztpraxen

Monitor Versorgungsforschung
Ziel dieser Studie ist die Analyse der Häufigkeit von sexuell übertragbaren Krankheiten (STI) in dermatologischen, urologischen und gynäkologischen Praxen in Deutschland. Die Daten hierfür sind der bundesweiten IQVIA-Disease-Analyzer-Datenbank entnommen.
Prof. Dr. rer. med. habil. Karel Kostev MA, Prof. Dr. med. Matthias Kalder   +1 more
doaj   +1 more source

Real‐Time in Vivo Monitoring of Circulating Endometrial Cells: Uncovering Systemic Dissemination and Temporal Fluctuations in Endometriosis

Advanced Science, EarlyView.
A dual‐color pseudo‐menstrual mouse model enables real‐time tracing of circulating endometrial cells (CECs) from uterine and ectopic sources. The study reveals menstrual‐phase‐dependent, burst‐like CEC release, distinct postoperative behaviors of different CEC origins, and a potential association with prolactin fluctuations, providing an in vivo ...
Shang Wang, Chenyu Hou, Buyun Li, Hongyan Cheng, Xue Ye, Honglan Zhu, Yanmin Li, Rui Chen, Sihan Dong, Yi Li, Huiping Liu, Chen Zhang, Rui Zhang, Hongyi Hou, Xunbin Wei, Xiaohong Chang   +15 more
wiley   +1 more source

Education level is associated with the occurrence and timing of hysterectomy: A cohort study of Canadian women

Acta Obstetricia et Gynecologica Scandinavica
Introduction Hysterectomy is a common surgery with discernible practice variations that could be influenced by socioeconomic factors. We examined the association between level of educational attainment and the occurrence and timing of hysterectomy in ...
Erin A. Brennand, Natalie V. Scime, Beili Huang, Pauline McDonagh Hull   +3 more
doaj   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Next‐generation monitoring in obstetrics: Assessing the accuracy of non‐piezo portable ultrasound technology

Acta Obstetricia et Gynecologica Scandinavica
Introduction The emergence of handheld ultrasound devices capable of connecting to cell phones or tablets heralds a significant advancement in medical technology, particularly within the field of obstetrics.
Ruben Plöger, Charlotte Behning, Adeline Walter, Jorge Jimenez Cruz, Ulrich Gembruch, Brigitte Strizek, Florian Recker   +6 more
doaj   +1 more source