Results 61 to 70 of about 751,444 (235)
Advanced Science, EarlyView.This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo +17 more
wiley +1 more source
Advanced Science, EarlyView.Programmable chaotic suspension electrolysis bridges laboratory synthesis and industrial manufacturing of high‐performance MnO2 cathodes. This scalable strategy enables tunable oxygen vacancies and a robust γ/β tunnel framework, delivering superior electrochemical performance and thermal stability.
Zhihao Wu +16 more
wiley +1 more source
Advanced Science, EarlyView.In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu +7 more
wiley +1 more source
Revealing the Giant Electromechanical Effects in Yttria‐Stabilized Zirconia Single Crystal
Advanced Science, EarlyView.Giant electromechanical responses are uncovered in yttria‐stabilized zirconia single crystal (SC‐YSZ), exhibiting pronounced orientation dependence. The giant electrostriction and piezoelectricity are directly correlated with the long‐range transport kinetics of oxygen vacancies.
Zhuwu Yi +8 more
wiley +1 more source
Video (sound only, no image) of a man remembering taking part in a play at Curve
, 2014 A video (duration 34 seconds) with the image blanked out , the audio is a man talking about his positive memories of taking part in the play "East" by Stephen Berkoff at Curve, directed by Paul Kerryson, and how the experience influenced his future.When ...
Anonymous;
core
Advanced Science, EarlyView.Condensates at synapses organize synaptic vesicles (SVs) and are crucial for efficient neurotransmitter release, yet how RNA contributes to this mesoscale architecture remains poorly understood. Here we uncover that RNA modulates synapsin–driven condensates.
Branislava Rankovic +21 more
wiley +1 more source
This paper provides evidence for the existence of a wage curve -- a micro-econometric association between the level of pay and the local unemployment rate -- in modern U.S. data. Consistent with recent evidence from more than 40 other countries, the wage
David G. Blanchflower, Andrew J. Oswald
core
Comparison between the RSA cryptosystem and elliptic curve cryptography [PDF]
, 2010 In the globalization era, cryptography becomes more popular and powerful; in fact it is very important in many areas (i.e. mathematics, computer science, networks, etc).
Abdullah, Kamilah
core
Advanced Science, EarlyView.Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang +4 more
wiley +1 more source