Results 41 to 50 of about 40,844 (184)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

On some Opial-type inequalities

Journal of Inequalities and Applications, 2011
In the present paper we establish some new Opial-type inequalities involving higher-order partial derivatives. Our results in special cases yield some of the recent results on Opial's inequality and also provide new estimates on inequalities of this type.
Cheung Wing-Sum, Zhao Chang-Jian
doaj  

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

On Minkowski's inequality and its application

Journal of Inequalities and Applications, 2011
In the paper, we first give an improvement of Minkowski integral inequality. As an application, we get new Brunn-Minkowski-type inequalities for dual mixed volumes.
Cheung Wing-Sum, Zhao Chang-Jian
doaj  

Convergence Rate Analysis for Fixed-Point Iterations of Generalized Averaged Nonexpansive Operators [PDF]

arXiv, 2021
We estimate convergence rates for fixed-point iterations of a class of nonlinear operators which are partially motivated from solving convex optimization problems. We introduce the notion of the generalized averaged nonexpansive (GAN) operator with a positive exponent, and provide a convergence rate analysis of the fixed-point iteration of the GAN ...
arxiv  

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

On generalized Milne type inequalities for new conformable fractional integrals

Filomat
In this study, we first obtained a new identity for differentiable convex functions with the help of new conformable fractional integrals. Then, using this identity, we proved new Milne-type inequalities for new conformable fractional integrals.
Barış Çelik, H. Budak, E. Set
semanticscholar   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Unitarily invariant norms related to factors [PDF]

arXiv, 2007
Let $\M$ be a semi-finite factor and let $\J(\M)$ be the set of operators $T$ in $\M$ such that $T=ETE$ for some finite projection $E$. In this paper we obtain a representation theorem for unitarily invariant norms on $\J(\M)$ in terms of Ky Fan norms.
arxiv  

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source