Results 61 to 70 of about 40,844 (184)

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

H$\ddot{o}$lder continuity for stochastic fractional heat equation with colored noise [PDF]

arXiv, 2016
In this paper, we consider semilinear stochastic fractional heat equation $\frac{\partial}{\partial t}u_{\beta,t}(x)=\triangle^{\alpha/2}u_{\beta,t}(x)+\sigma(u_{\beta,t}(x))\eta_{\beta}$. The Gaussian noise $\eta_{\beta}$ is assumed to be colored in space with covariance of the form $E(\eta_{\beta}(t,x)\eta_{\beta}(s,y))=\delta(t-s)f_{\beta}(x-y ...
arxiv  

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Asymptotic Stability of the Lane-Emden Solutions for the Viscous Gaseous Star Problem with Degenerate Density Dependent Viscosities [PDF]

, 2015
The nonlinear asymptotic stability of Lane-Emden solutions is proved in this paper for spherically symmetric motions of viscous gaseous stars with the density dependent shear and bulk viscosities which vanish at the vacuum, when the adiabatic exponent $\gamma$ lies in the stability regime $(4/3, 2)$, by establishing the global-in-time regularity ...
arxiv   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

On Fourier multipliers in function spaces with partial Hölder condition and their application to the linearized Cahn-Hilliard equation with dynamic boundary conditions [PDF]

arXiv, 2014
We give relatively simple sufficient conditions on a Fourier multiplier, so that it maps functions with the H$\ddot{o}$lder property with respect to a part of the variables to functions with the H$o$lder property with respect to all variables. With the using of these sufficient conditions we prove the solvability in H$\ddot{o}$lder classes of the ...
arxiv  

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Hölder continuity of the integrated density of states for Extended Harper's Model with Liouville frequency [PDF]

arXiv, 2017
In this paper, we study the non-self-dual extended Harper's model with a Liouville frequency. Based on the work of \cite{SY}, we show that the integrated density of states (IDS for short) of the model is $\frac{1}{2}$-H$\ddot{\text{o}}$lder continuous. As an application, we also obtain the Carleson homogeneity of the spectrum.
arxiv  

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Higher-order Derivative Local Time for Fractional Ornstein-Uhlenbeck Processes [PDF]

arXiv, 2018
In this article, existence of the $k$-th order derivatives of local time $ \widehat{\alpha}^{(k)}(x,t)$ is considered for two d-dimensional fractional Ornstein-Uhlenbeck processes $X^{H_1}_t$ and $\widetilde{X}^{H_2}_s$ with Hurst parameters $H_1$ and $H_2$, respectively.
arxiv