Results 71 to 80 of about 39,905 (162)
Molecular Oncology, EarlyView.Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale +9 more
wiley +1 more source
Molecular Oncology, EarlyView.The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu +3 more
wiley +1 more source
Global Existence of Smooth Solutions and Convergence to Barenblatt Solutions for the Physical Vacuum Free Boundary Problem of Compressible Euler Equations with Damping [PDF]
arXiv, 2014 For the physical vacuum free boundary problem with the sound speed being $C^{{1}/{2}}$-H$\ddot{\rm o}$lder continuous near vacuum boundaries of the one-dimensional compressible Euler equations with damping, the global existence of the smooth solution is proved, which is shown to converge to the Barenblatt self-similar solution for the the porous media ...
arxiv
Molecular Oncology, EarlyView.The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld +7 more
wiley +1 more source
Global Solutions to the Gas-Vacuum Interface Problem of Isentropic Compressible Inviscid Flows with Damping in Spherically Symmetric Motions and Physical Vacuum [PDF]
arXiv, 2014 For the physical vacuum free boundary problem with the sound speed being $C^{{1}/{2}}$-H$\ddot{\rm o}$lder continuous near vacuum boundaries of the three-dimensional compressible Euler equations with damping, the global existence of spherically symmetric smooth solutions is proved, which are shown to converge to Barenblatt self-similar solutions of the
arxiv
Molecular Oncology, EarlyView.Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam +2 more
wiley +1 more source
On Nonlinear Asymptotic Stability of the Lane-Emden Solutions for the Viscous Gaseous Star Problem [PDF]
arXiv, 2015 This paper proves the nonlinear asymptotic stability of the Lane-Emden solutions for spherically symmetric motions of viscous gaseous stars if the adiabatic constant $\gamma$ lies in the stability range $(4/3, 2)$. It is shown that for small perturbations of a Lane-Emden solution with same mass, there exists a unique global (in time) strong solution to
arxiv
Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance
Molecular Oncology, EarlyView.In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou +13 more
wiley +1 more source
Molecular Oncology, EarlyView.This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang +10 more
wiley +1 more source