Results 71 to 80 of about 40,844 (184)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Operator inequalities associated with Hölder–McCarthy and Kantorovich inequalities

Journal of Inequalities and Applications, 1998
We discuss operator inequalities associated with Hölder–McCarthy and Kantorovich inequalities. We give a complementary inequality of Hölder–McCarthy one as an extension of [2] and also we give an application to the order preserving power inequality.
openaire   +1 more source

Regularity and geometric character of solution of a degenerate parabolic equation [PDF]

arXiv, 2015
This work studies the regularity and the geometric significance of solution of the Cauchy problem for a degenerate parabolic equation $u_{t}=\Delta{}u^{m}$. Our main objective is to improve the H$\ddot{o}$lder estimate obtained by pioneers and then, to show the geometric characteristic of free boundary of degenerate parabolic equation. To be exact, the
arxiv  

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Convex inequalities in Hilbert $C^*$-modules [PDF]

arXiv
The H$\ddot{{\rm o}}$lder-McCarty inequalities are originally derived in the Hilbert space case and have been generalized via a convex inequality. The main purpose of this paper is to extend this convex inequality to the Hilbert $C^*$-module case, and meanwhile to make some investigations on the H$\ddot{{\rm o}}$lder-McCarty inequalities in the Hilbert
arxiv  

The Second Order Estimate for Fully Nonlinear Uniformly Elliptic Equations without Concavity Assumption [PDF]

arXiv, 2005
Investigating for interior regularity of viscosity solutions to the fully nonlinear elliptic equation $$F(x,u,\triangledown u,\triangledown ^2 u)=0,$$ we establish the interior $C^{1+1}$ continuity under the assumptions that $F$ is uniformly elliptic, H$\ddot o$lder continuous and satisfies the natural structure conditions of fractional order, but ...
arxiv  

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

A Note on Hölder Type Inequality for the Fermionic p-Adic Invariant q-Integral

Journal of Inequalities and Applications, 2009
The purpose of this paper is to find Hölder type inequality for the fermionic p-adic invariant q-integral which was defined by Kim (2008).
openaire   +2 more sources

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source