Results 31 to 40 of about 2,542 (110)

Stratification by a polygenic risk score of common variation aids in Alzheimer's disease rare variant discovery

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION We utilized an Alzheimer's disease (AD) polygenic risk score (PRS) to discover associations with novel rare variants (RVs). METHODS PRSs for European ancestry (EA) participants of the Alzheimer's Disease Sequencing Project were calculated using summary statistics from a large genome‐wide association study.
Oluwatosin Olayinka, John J. Farrell, Congcong Zhu, Zainab Khurshid, Alzheimer's Disease Sequencing Project, Eden R. Martin, William S. Bush, Margaret A. Pericak‐Vance, Li‐San Wang, Gerard D. Schellenberg, Jonathan L. Haines, Kathryn L. Lunetta, Xiaoling Zhang, Lindsay A. Farrer   +13 more
wiley   +1 more source

Acquired von Willebrand syndrome and lymphoproliferative disorders: A case report

Clinical Case Reports, 2020
Acquired von Willebrand syndrome is a rare bleeding disorder often secondary to an underlying lymphoproliferative disorder. We report a case in whom response of both the acquired von Willebrand syndrome and smoldering multiple myeloma persist 14 months ...
Christophe Nicol, Leela Raj, Gaëlle Guillerm, Francis Couturaud, Jean‐Richard Eveillard, Brigitte Pan‐Petesch   +5 more
doaj   +1 more source

Analysis of Human Thymopoiesis Reveals Rapid Postnatal Remodeling of Thymocytes Within the First 3 Months of Life

European Journal of Immunology, Volume 56, Issue 8, August 2026.
Human thymopoiesis undergoes a dynamic postnatal transition, revealing maximal intrathymic sjTREC production at birth, shifts in thymocyte phenotype and composition, and a transient wave of effector Vδ2+ γδ T cells during early infancy. ABSTRACT The thymus generates a diverse and self‐tolerant T‐cell repertoire.
Camille Kergaravat, Jean‐Marc Doisne, Clarisse Godard, Agata Cieslak, Mourad Amrane, David Vermijlen, Vahid Asnafi, Kamel Benlagha, James P. Di Santo, Emmanuel Clave, Antoine Toubert   +10 more
wiley   +1 more source

Paludisme chez les drépanocytaires de forme majeurs : aspects épidémiologiques, cliniques, thérapeutiques et évolutif au service d’hématologie de l’hôpital national Ignace Deen de Conakry

Revue Malienne d’Infectiologie et de Microbiologie, 2022
Objectif : Contribuer à l’amélioration de la prise en charge de la drépanocytose associée au paludisme dans le service d’hématologie du CHU de Conakry par la description des aspects épidémiologique, clinique, thérapeutique et évolutif.
Mamady DIAKITE , et. al
doaj   +2 more sources

Une polyradiculonévrite inflammatoire démyélinisante chronique paranéoplasique secondaire à un lymphome natural killer nasal

The Pan African Medical Journal, 2020
Nous rapportons un cas unique d´une polyradiculonévrite inflammatoire démyélinisante chronique paranéoplasique secondaire à un lymphome non hodgkinien T de type natural killer nasal.
Selim Jennane, Nawal Hasnaoui, Mahtat El Mehdi, Hicham El Maaroufi, Nezha Messaoudi, Mohamed Mikdame, Kamal Doghmi   +6 more
doaj   +1 more source

Outcomes of refractory and early‐relapsed large B‐cell lymphoma patients after first‐line treatment in the prospective Real‐world dAta in LYmphoma patients and Survival in Adults (REALYSA) cohort in the pre‐CAR T era

British Journal of Haematology, EarlyView.
Stéphanie Guidez, Aurélien Belot, Fanny Cherblanc, Bastien Lesné, Sylvain Carras, Catherine Thieblemont, Fontanet Bijou, Cédric Rossi, Luc Mathieu Fornecker, Jehan Dupuis, Krimo Bouabdallah, Ludovic Fouillet, Adrien Chauchet, Benoit Tessoulin, Loic Ysebaert, Alice Pauc, Pascale Cony‐Makhoul, Remy Gressin, Gaelle Laboure, Antoine Bonnet, Sandy Amorim, Christophe Fruchart, Roch Houot, Gian Matteo Pica, Carole Soussain, Sophie Dennetiere, Cécile Leyronnas, Pauline Lionne‐Huyghe, Hervé Ghesquières, Pierre Sesques   +29 more
wiley   +1 more source

Major Platelet Disease Revealing Chronic Myeloid Leukemia in Abidjan

Health Research in Africa
RÉSUMÉ L’hyperplaquettose est une circonstance de découverte rare de la leucémie myéloïde chronique, c’est une urgence diagnostique et thérapeutique du fait de son pronostic péjoratif en lien avec complications thromboemboliques.
Kouakou ANJI, Bognini SAA, Silue A, N’Ri C, Kouassi Y, Djeket RE, Silue A, Kouakou B, Kamara I, Kouehion P, Koffi G   +10 more
doaj   +1 more source

Engineering Soluble Recombinant BCMA for Ide‐Cel Labeling

European Journal of Immunology, Volume 56, Issue 7, July 2026.
This study describes the generation of a recombinant IFNα2‐BCMAext‐GFP probe, which enables sensitive detection of BCMA‐directed CAR‐T cells. The probe efficiently identifies idecabtagene vicleucel (ide‐cel) CAR‐T cells in patients with multiple myeloma and provides a simple alternative to current BCMA‐based detection reagents.
Ly Phuong Vy Nguyen, Christelle Oblet, Alice Barbarin, Louis Waeckel, Farah Kotaich, Clara Petit, Marine Mabily, Claire Carrion, André Herbelin, Jean Marc Gombert, Xavier Leleu, Emilie Chalayer, Murielle Roussel, Patrick Legembre   +13 more
wiley   +1 more source

Surveillance of CMV Terminase Gene Mutations in Allogeneic Hematopoietic Stem Cell Transplant Recipients Receiving Letermovir Prophylaxis

Journal of Medical Virology, Volume 98, Issue 7, July 2026.
ABSTRACT Letermovir (LMV), a CMV‐specific terminase inhibitor, is recommended for cytomegalovirus (CMV) prophylaxis in CMV‐seropositive allogeneic hematopoietic stem cell transplant (alloHSCT) recipients. The association between low‐level CMV DNAemia during prophylaxis and the emergence of mutations in CMV terminase complex genes remains unclear.
Amandine Caillault, Alienor Xhaard, Severine Mercier‐Delarue, Linda Feghoul, Julien Robert, Nathalie Schnepf, David Michonneau, Marie Robin, Flore Sicre de Fontbrune, Eleonore Kaphan, Mathilde Ruggiu‐Goiran, Pedro Henrique de Lima Prata, Florian Chevillon, Matthieu Jestin, Nathalie Dhedin, Gerard Socie, Régis Peffault de Latour, Maud Salmona, Jérôme LeGoff   +18 more
wiley   +1 more source

International multicentre evaluation of a new anti‐idiotypic anti‐daratumumab for resolving pre‐transfusion interferences

Vox Sanguinis, Volume 121, Issue 7, Page 1065-1075, July 2026.
Abstract Background and Objectives Daratumumab, a therapeutic human anti‐CD38 monoclonal antibody, improves multiple myeloma outcomes but interferes with pre‐transfusion testing by binding CD38 on reagent red blood cells (RBCs), potentially masking clinically significant alloantibodies.
Arnaud Reggiani, Sofia Lejon Crottet, Sophie Waldvogel, Charlotte Engström, Serelina Coluzzi, Antonella Matteocci, Janis R. Hamilton, Levent Tufan Kumas, Karen M. K. de Vooght, Jill R. Storry, Jennylyn Flores, Núria Nogués, Carlos Cotorruelo, Molly Rutherford, Eveline B. Nilsen, Monika Pelc‐Kłopotowska, Jolanta Korzeniowska, Alessandra Baffa, Inna Sareneva, Nor Hafizah Ahmad, Katarzyna Szczudlo, Athif Rahman, Laser Sanal, Lise Jørgensen, Karolina Majewska Rochowiak, Monika Salwierz, Elisaveta Grancharova, Bojana Zivkovic, Jessica Alvarez, Mareike Riedl, Achim Knappik   +30 more
wiley   +1 more source