Results 81 to 90 of about 252,478 (236)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

open access: yesFEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

open access: yesFEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court   +3 more
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

open access: yesFEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller   +3 more
wiley   +1 more source

Đánh giá độ ổn định của điểm đồng tâm cơ khí, góc quay của collimator, gantry và bàn điều trị trong máy gia tốc tuyến tính

open access: yes, 2023
5 tr.Collimator, gantry và bàn điều trị trong máy gia tốc tuyến tính là những bộ phận quan trọng dùng trong xạ trị. Sự ổn định về chuyển động cơ khí của ba thành phần nói trên là một trong các yếu tố quan trọng ảnh hưởng tới việc điều trị. Nghiên cứu này
Hoàng, Anh Tùng
core   +1 more source

GIẢI THUẬT ĐỊNH VỊ VỊ TRÍ TRONG KHÔNG GIAN 3-D CHO THẺ RFID DỰA VÀO CƯỜNG ĐỘ TÍN HIỆU (RSS)

open access: yesTạp chí Khoa học Đại học Cần Thơ, 2014
Những năm gần đây, công nghệ RFID đã phát triển vượt bậc và thu hút sự quan tâm đặc biệt trong việc xây dựng một giải thuật định vị phù hợp để ứng dụng thực tế hiệu quả [4].
Vũ Đức Lung   +2 more
doaj  

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

open access: yesFEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page   +4 more
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

open access: yesAging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi   +3 more
wiley   +1 more source

RỪNG NGẪU NHIÊN CẢI TIẾN CHO PHÂN LOẠI DỮ LIỆU GIEN

open access: yesTạp chí Khoa học Đại học Cần Thơ, 2012
Trong bài viết này, chúng tôi đề xuất giải thuật rừng ngẫu nhiên cải tiến cho phân lớp dữ liệu gien thường có rất ít các phần tử dữ liệu nhưng số chiều rất lớn và có nhiễu.
Huỳnh Phụng Toàn   +3 more
doaj  

Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons   +33 more
wiley   +1 more source

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