Results 141 to 150 of about 11,920,025 (242)
The Maintenance of Dysmyelinated Small‐Diameter Axons by 14‐3‐3s in the Central Nervous System
Glia, Volume 74, Issue 11, November 2026.Dysmyelinated small‐diameter axons are maintained in teneurin‐4 deficient mice at the age of 1 year, while axonal damage is observed. 14‐3‐3s are highly expressed and suppress the progression of the damage in these axons. ABSTRACT In the central nervous system, myelin formed around nerve axons by oligodendrocyte enables efficient conduction of action ...
Nanako Yamada +15 more
wiley +1 more source
Extracellular Vesicles for Space Biomedical Research
Journal of Extracellular Vesicles, Volume 15, Issue 11, November 2026.Microgravity reshapes EV biogenesis and cargo selection, which brings new opportunities for longitudinal liquid‐biopsy readouts of stress and aging‐like trajectories, as well as the regenerative products in spaceflight research. ABSTRACT Extracellular vesicles (EVs) are regulated, information‐rich nanovesicles that reflect aspects of parent‐cell state,
Samantha Ali +10 more
wiley +1 more source
MedComm, Volume 7, Issue 11, November 2026.This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin +6 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.DE‐CQ, an NAD(P)H‐activatable theranostic probe, enables the quantification of cancer aggressiveness via glucose‐stimulated fluorescence imaging and selectively induces apoptosis. Its multifaceted efficacy is demonstrated across 2D cells, 3D spheroids, and in vivo models.
Yujin Cha +11 more
wiley +2 more sources
Magnetic Resonance in Medicine, Volume 96, Issue 5, Page 2240-2252, November 2026.ABSTRACT Purpose To evaluate single‐ and dual‐band pulse modules for suppressing extra‐cardiac signal in cardiac MRI, and test their applicability for time‐efficient imaging with reduced FOV in myocardial T2 mapping at 3 T. Methods Outer Volume Suppression (OVS) was implemented using two regional saturation slabs, along the phase‐encoding direction ...
Ayda Arami +8 more
wiley +1 more source
Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries
British Journal of Pharmacology, Volume 183, Issue 22, Page 6607-6626, November 2026.Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 21, Page 6261-6290, November 2026.Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley +1 more source
Watermelon genotype‐independent transformation via direct organogenesis from the cotyledon base
Journal of Integrative Plant Biology, Volume 68, Issue 11, Page 3871-3873, November 2026.Inducing adventitious buds from the base of watermelon cotyledon through direct organogenesis resulted in a watermelon genetic transformation system that overcomes regeneration barriers and genotype limitations.
Jing Zhang +6 more
wiley +1 more source
AKT Phosphorylation of FOXK2 at Ser398 Impacts Breast Cancer Cell Growth and Viability
The FASEB Journal, Volume 40, Issue 20, 31 October 2026.Higher FOXK2 protein levels are associated with increased AKT phosphorylation and chemoresistance in breast cancer cells. AKT modulates FOXK2 protein levels, with no such regulation in FOXK2 mRNA levels. GSK3β, a known substrate of AKT (dotted arrow), does not regulate FOXK2 in our cellular model.
L. T. Carneiro +10 more
wiley +1 more source
ChemMedChem, Volume 21, Issue 19, 14 October 2026.Hit‐to‐lead optimization of morpholinephenylbenzamides reveals key structure–activity relationships against Trypanosoma cruzi and Leishmania infantum. Potency, selectivity, and ADME properties are differentially improved across the series, identifying compounds 20, 24, and 16 as complementary templates for the future design of dual antiparasitic leads.
Danilo Nascimento Farago +15 more
wiley +1 more source