Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Mediterranean lifestyle index and 24-h systolic blood pressure and heart rate in community-dwelling older adults [PDF]
Irene Talavera +8 more
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The role of histone modifications in transcription regulation upon DNA damage
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
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Using the H-index as a factor in the promotion of surgical faculty. [PDF]
Wang R +5 more
europepmc +1 more source
Rothe, H. (ed.). Die älteste ostslawische Kunstdichtung 1575-1647. Bausteine zur Geschichte der Literatur bei den Slawen, Band 7, 1-2 with Supplement. Wilhelm Schmitz Verlag, Giessen, 1976-7. xviii + vi + 533 + 48 pages. Indexes. Illustrations. [PDF]
Arnold McMillin
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Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
This study investigates a phenomenon in the educational world: using cell phones during teaching and learning in English classes. Cell phones here are referred to as inappropriate use, not as a supportive device in teaching and learning, reducing ...
Ridha Fadillah, Akhmad Adi Purnawarman
doaj +1 more source
Quantifying research interests in 7,521 mammalian species with h-index: a case study. [PDF]
Tam J, Lagisz M, Cornwell W, Nakagawa S.
europepmc +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source

