Results 261 to 270 of about 20,214,169 (332)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

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Robust h-index

Scientometrics, 2021
The h-index is the most used measurement of impact for researchers. Sites such as Web of Science, Google Scholar, Microsoft Academic, and Scopus leverage it to show and compare the impact of authors. The h-index can be described in simple terms: it is the highest h for which an authors has h papers with the number of cites more or equal than h ...
Maurice Poirrier, Sebastián Moreno, Gonzalo Huerta-Cánepa   +2 more
openaire   +2 more sources

Why h-Index

2020
At present, one of the main ways to gauge the quality of a researcher is to use his or her h-index, which is defined as the largest integer n such that the researcher has at least n publications each of which has at least n citations. The fact that this quantity is widely used indicates that h-index indeed reasonably adequately describes the researcher’
Kreinovich, Vladik, Kosheleva, Olga, Phuong, Nguyen Hoang   +2 more
openaire   +2 more sources

A review on h-index and its alternative indices

Journal of information science, 2021
In recent years, several scientometrics and bibliometrics indicators were proposed to evaluate the scientific impact of individuals, institutions, colleges, universities and research teams.
Anand Bihari, Sudhakar Tripathi, A. Deepak   +2 more
semanticscholar   +1 more source

h-Index and Academic Rank by Gender Among Breast Surgery Fellowship Faculty

Journal of Women's Health, 2021
Background: Gender disparities in academic promotion and leadership are well documented. Scholarly impact is essential for promotion. The Hirsch-index (h-index) is a measure of impact using number of publications and citations.
D. Radford, S. Parangi, C. Tu, J. Silver
semanticscholar   +1 more source

EHC: Extended H-index Centrality measure for identification of users’ spreading influence in complex networks

Physica A: Statistical Mechanics and its Applications, 2019
In recent research, the importance of determining social network users’ spreading influence and ranking them has attracted plenty of attention. H-index is one of the methods that have been presented for this purpose, and determines the spreading ...
A. Zareie, Amir Sheikhahmadi
semanticscholar   +1 more source