Results 71 to 80 of about 13,122,822 (311)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Developing Scientific Writing of Lower Secondary Students through Inquiry and Science Writing Heuristic Learning

open access: yesJurnal Penelitian dan Pembelajaran IPA, 2020
This action research aims to develop scientific writing of lower secondary students through inquiry and science writing heuristic learning. Participants were 15 of grade 9 students from one school in Sisaket province, Thailand. Ten lesson plans including
Jirun Nuntasane   +2 more
doaj   +1 more source

New developments related to the Hirsch index [PDF]

open access: yes, 2006
It is shown that the h-index on the one hand, and the A- and g-indices on the other, measure different things. The A-index, however, seems overly sensitive to one extremely highly cited article.
Rousseau, Ronald
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Wastes Management Can Minimize CH4 and N2O Emissions from Wetlands in Indonesia

open access: yesJournal of Wetlands Environmental Management, 2015
Paddy (Oriza sativa L.) and Oil palm (Elaeis guineensis Jack) are two important crops and are potential to produce wastes which may lead to huge greenhouse gas emissions if they are not managed properly.
Abdul Hadi   +6 more
doaj  

Applying successive H indices in the institutional evaluation: a case study [PDF]

open access: yes, 2008
The present work shows the applying of successive H indices in the evaluation of a scientific institution, using the researcher-department-institution hierarchy as level of aggregation.
Barrios Almaguer, Ismaray   +7 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Religious and Cultural Existences Within the Communities of Upper Kapuas Riverside of West Kalimantan

open access: yesAl-Albab, 2017
The sudies on the issues related to communities in the interior of West Kalimantan begin to take place when Dutch and other European scholars in the colonial period came to the region. But they have been limitedly documented.
Zaenuddin Hudi Prasojo
doaj   +1 more source

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