Results 111 to 120 of about 105,092 (319)

Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance

Interdisciplinary Medicine, EarlyView.
This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang, Tong Jiang, Yaling Lin, Wei Zhang, Hongjie Fan, Minjie Yang, Bingzhe Li, Yaozu Liu, Changyu Li, Xuran Jin, Wen Zhang, Zhiping Yan, Qianqian Zhao, Xuefeng Kan, Xudong Qu   +14 more
wiley   +1 more source

The effect of Helicobacter pylori infection on oxidative stress status in erosive reflux disease

Medical Journal of Dr. D.Y. Patil University, 2013
Background and Objectives: Helicobacter pylori (H. pylori) infection has been associated with increased production of reactive oxygen species, which leads to oxidative stress in the gastrointestinal mucosa. Nevertheless, the association of H.
Masoud Sadreddini, Yousef Rasmi, Zahra Shahsavari, Fariba Khosravifar, Mohammad Rahmati   +4 more
doaj   +1 more source

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li, Han Li, Bojie Chen, Ling Jiang, Keyu Long, Jiaqi Lang, Xingxiang Pu, Erhu Xiong   +7 more
wiley   +1 more source

Inhibitors of Helicobacter pylori protease HtrA found by "virtual ligand" screening combat bacterial invasion of epithelia [PDF]

, 2011
Background: The human pathogen Helicobacter pylori (H. pylori) is a main cause for gastric inflammation and cancer. Increasing bacterial resistance against antibiotics demands for innovative strategies for therapeutic intervention.
Löwer, Martin, Schneider, Gisbert, Petra Schneider, Hoy Benjamin, Löwer Martin, Martin Löwer, Tim Geppert, Geppert, Tim, Silja Wessler, Wessler Silja, Schneider, Petra, Geppert Tim, Gisbert Schneider, Benjamin Hoy, Hoy, Benjamin, Weßler, Silja, Schneider Petra, Schneider, Gisbert (Prof. Dr.), Schneider Gisbert   +18 more
core   +1 more source

A Comprehensive Study of Bidirectional Interactions Between the Human Microbiome and Blood Malignancies and Hematologic Conditions: Focus on Novel Therapeutic Strategies

Journal of Clinical Laboratory Analysis, EarlyView.
Microbiota‐targeted therapeutic strategies in hematological disorders. aHSCT: Transplanted immune cells from the donor may attack the recipient's tissues, especially when damage to the intestinal epithelium disrupts the gut microbiota, contributing to GVHD. Maintaining a balanced gut microbiota that supports immune regulation helps reduce GVHD risk and
Alireza Molajafari, Hadi Sedigh Ebrahim‐Saraie, Majid Taati Moghadam, Meysam Hasannejad‐Bibalan   +3 more
wiley   +1 more source

Short stature and Helicobacter pylori infection in Italian children: prospective multicentre hospital based case–control study. (I.F. 5.143) [PDF]

, 1998
Helicobacter pylori is mainly acquired in childhood,1 but the diseases associated with such infection remain unknown. Scottish and Italian schoolchildren infected with H pylori showed reduced growth in height,2,3 and H pylori gastritis was found in 55 ...
E. Chiorboli, G. Bona, DE ANGELIS, Gian Luigi, on behalf of the Italian Study Group on Short Stature end H. Pylori, C. Saieva, D. Palli, G. Oderda   +6 more
core  

High prevalence of ultra‐short celiac disease in children with low anti‐tissue transglutaminase immunoglobulin A levels: The risk of misdiagnosis without bulb biopsy

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Despite recent advances in diagnostics, celiac disease (CD) diagnosis remains challenging. Ultra‐short celiac disease (USCD) has been proposed as a distinct phenotype characterized by villous atrophy confined to the duodenal bulb, positive celiac serology, and clinical features consistent with CD.
Antonio Pizzol, Eleonora Saraceno, Anna Opramolla, Laura Giugliano, Cristina Chiadò, Tilde Manetta, Gabriella Canavese, Enrico Falco, Michele Pinon, Pier Luigi Calvo   +9 more
wiley   +1 more source

Eradication of gastric Helicobacter Pylori : are we getting there? [PDF]

, 1995
In 1984 a curved bacillus living in the stomach of patients with gastritis and peptic ulceration was discovered and isolated. This organism named as Helicobacter Pylori (HP), has been shown to play a major role in the causation of duodenal ulcers ...
Pullicino, Edgar
core  

Clinical characteristics of ulcerative colitis patients with different types of Helicobacter pylori infection

Microbiology Spectrum
There has been a suggestion of a potential protective effect of Helicobacter pylori (H. pylori) in the development of ulcerative colitis (UC). Virulence factor is an important factor in H. pylori, but little is known about the clinical characteristics of
Weidong Liu, Qi Jiang, Shenglong Xue, Wenjia Hui, Wenjie Kong, Mengxia Zhang, Feng Gao   +6 more
doaj   +1 more source

Foreign body ingestions in children and adolescents: A position paper of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) endoscopy special interest group

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Foreign body (FB) ingestion is a relatively frequent occurrence in the pediatric population with multiple potential sequelae. Appropriate intervention may range from urgent endoscopic retrieval to watchful waiting, with multiple variables influencing the decision.
Oren Ledder, Raoul Furlano, Alexandra Papadopoulou, Dominique Schluckebier, Andreia Nita, Christos Tzivinikos, Salvatore Oliva, Simona Faraci, Luigi Dall'oglio, Marco Deganello Saccomani, Priya Narula, Iva Hojsak, Jorge Amil Dias, Vasiliki Spyropoulou, Lorenzo Norsa, Gokhan Baysoy, Claudio Romano, Matjaž Homan, Mike Thomson   +18 more
wiley   +1 more source