Results 1 to 10 of about 5,620 (149)

Imaging features associated with H3 K27-altered and H3 G34-mutant gliomas: a narrative systematic review [PDF]

Cancer Imaging, 2022
Background Advances in molecular diagnostics accomplished the discovery of two malignant glioma entities harboring alterations in the H3 histone: diffuse midline glioma, H3 K27-altered and diffuse hemispheric glioma, H3 G34-mutant. Radiogenomics research,
Arian Lasocki, Gehad Abdalla, Geoffrey Chow, Stefanie C. Thust   +3 more
doaj   +7 more sources

Transcriptomic and proteomic spatial profiling of pediatric and adult diffuse midline glioma H3 K27-Altered [PDF]

Scientific Reports
Diffuse midline glioma, H3 K27-altered (DMG) are highly aggressive malignancies of the central nervous system (CNS) that primarily affect the pediatric population.
Sudarshawn Damodharan, Jack M. Shireman, Elliot Xie, Emily Distler, Christina Kendziorski, Mahua Dey   +5 more
doaj   +7 more sources

MRI comparative study of diffuse midline glioma, H3 K27-altered and glioma in the midline without H3 K27-altered [PDF]

BMC Neurology, 2022
Purpose The MRI features of Diffuse midline glioma, H3 K27-altered and glioma in the midline without H3 K27-altered were compared and analyzed, and the changes in the apparent diffusion coefficient (ADC) of the two groups were quantitatively analyzed ...
Ji-ping Zhao, Xue-jun Liu, Hao-zhi Lin, Chun-xiao Cui, Ying-jie Yue, Song Gao, Hong-zhang Xu   +6 more
doaj   +8 more sources

Case Report: Rare intraventricular H3 K27-altered diffuse midline glioma in an adult [PDF]

Frontiers in Oncology
H3 K27-Altered Diffuse Midline Gliomas are commonly found in children and adolescents in midline locations such as the thalamus, brain stem, and spinal cord.
Merari Jasso, Jay-Jiguang Zhu, Meenakshi B. Bhattacharjee, Georgene W. Hergenroeder   +3 more
doaj   +4 more sources

Adult spinal cord diffuse midline glioma, H3 K27-altered mimics symptoms of central nervous system infection: a case report [PDF]

Frontiers in Neurology, 2023
Diffuse midline gliomas, H3 K27-altered are infiltrative growth gliomas with histone H3K27M mutations. This glioma is more common in the pediatric population, and the prognosis is usually poor.
Xue Chen, Yi Li, Hui Bu, YueLi Zou, JunYing He, Hu Liu   +5 more
doaj   +4 more sources

Extra-neural metastases in pediatric diffuse midline gliomas, H3 K27-altered: presentation of two cases and literature review [PDF]

Frontiers in Molecular Neuroscience, 2023
IntroductionPediatric diffuse midline gliomas (DMG), H3 K27- altered, are the most aggressive pediatric central nervous system (CNS) malignancies. Disease outcome is dismal with a median survival of less than one year.
Lucia De Martino, Stefania Picariello, Carmela Russo, Maria Elena Errico, Pietro Spennato, Maria Rosaria Papa, Nicola Normanno, Giuseppe Scimone, Giovanna Stefania Colafati, Antonella Cacchione, Angela Mastronuzzi, Maura Massimino, Giuseppe Cinalli, Lucia Quaglietta   +13 more
doaj   +4 more sources

Convergent evolution and multi-wave clonal invasion in H3 K27-altered diffuse midline gliomas treated with a PDGFR inhibitor [PDF]

Acta Neuropathologica Communications, 2022
The majority of diffuse midline gliomas, H3 K27-altered (DMG-H3 K27-a), are infiltrating pediatric brain tumors that arise in the pons with no effective treatment.
Sasi Arunachalam, Karol Szlachta, Samuel W. Brady, Xiaotu Ma, Bensheng Ju, Bridget Shaner, Heather L. Mulder, John Easton, Benjamin J. Raphael, Matthew Myers, Christopher Tinkle, Sariah J. Allen, Brent A. Orr, Cynthia J. Wetmore, Suzanne J. Baker, Jinghui Zhang   +15 more
doaj   +4 more sources

H3 K27-altered diffuse midline glioma in adults arising from atypical regions: Two case reports and literature review [PDF]

Radiology Case Reports
Diffuse midline glioma (DMG), H3 K27-altered, is a newly defined “pediatric-type,” diffuse, high-grade glioma under current WHO classifications (updated in 2021).
Narushi Sugii, MD, PhD, Yuki Ninomiya, MD, Yu Akimoto, MD, Takao Tsurubuchi, MD, PhD, Eiichi Ishikawa, MD, PhD   +4 more
doaj   +4 more sources

A rare case of adult H3 K27-altered diffuse midline glioma with multifocal cerebrospinal fluid disseminated disease [PDF]

Radiology Case Reports
H3 K27-altered diffuse midline gliomas are a group of highly aggressive glial brain tumors that occur predominantly in children and carry a poor prognosis with limited treatment options.
Jackie Chen, BMedSc, MD, Samuel Conyngham, MBBS, Angela Bayly, MBBS, Jacqueline McMaster, BSci, BMed, Jason Trang, MBBS   +4 more
doaj   +2 more sources

Clinico–Pathological Features of Diffuse Midline Glioma, H3 K27-Altered in Adults: A Comprehensive Review of the Literature with an Additional Single-Institution Case Series [PDF]

Diagnostics
Background: Diffuse midline glioma (DMG), H3 K27-altered, is a WHO grade 4 malignant glioma located at midline structures, including the thalamus, brainstem and spinal cord.
Giuseppe Broggi, Serena Salzano, Maria Failla, Giuseppe Maria Vincenzo Barbagallo, Francesco Certo, Magda Zanelli, Andrea Palicelli, Maurizio Zizzo, Nektarios Koufopoulos, Gaetano Magro, Rosario Caltabiano   +10 more
doaj   +2 more sources