Results 91 to 100 of about 5,620 (149)

Three and Four Courses of Radiation for Children With Recurrent Diffuse Intrinsic Pontine Glioma

Pediatric Blood &Cancer, Volume 72, Issue 11, November 2025.
ABSTRACT Purpose Re‐irradiation (RT2) for children with diffuse intrinsic pontine glioma (DIPG) is increasingly used upon recurrence; however, limited data are available for evaluating additional courses of radiotherapy (RT) for DIPG. The purpose of this case series was to report our institutional experience in treating patients with recurrent DIPG ...
Nisha Shariff, Anthony Lausch, Eric Bouffet, Derek S. Tsang   +3 more
wiley   +1 more source

Multi-omics approaches reveal that diffuse midline gliomas present altered DNA replication and are susceptible to replication stress therapy

Genome Biology
Background The fatal diffuse midline gliomas (DMG) are characterized by an undruggable H3K27M mutation in H3.1 or H3.3. K27M impairs normal development by stalling differentiation.
Anastasia E. Hains, Kashish Chetal, Tsunetoshi Nakatani, Joana G. Marques, Andreas Ettinger, Carlos A. O. Biagi Junior, Adriana Gonzalez-Sandoval, Renjitha Pillai, Mariella G. Filbin, Maria-Elena Torres-Padilla, Ruslan I. Sadreyev, Capucine Van Rechem   +11 more
doaj   +1 more source

Role of histone methyltransferase “EZH2” in human cancer [PDF]

, 2011
Epigenetic alternations significantly contribute many disease progressions as the genetic changes do. However, there is a crucial difference between genetic and epigenetic alterations, which has important implications for development of cancer treatments.
Sahu, Rashmi Ranjan
core  

ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. [PDF]

, 2016
The androgen receptor (AR) is overexpressed and hyperactivated in human castration-resistant prostate cancer (CRPC). However, the determinants of AR overexpression in CRPC are poorly defined.
Borowsky, Alexander D, Cai, Demin, Chen, Hong-Wu, Duan, Zhijian, Evans, Christopher P, Evans, Ronald M, Gao, Allen C, Kung, Hsing-Jien, Lam, Kit S, Louie, Maggie C, Wang, Junjian, Xiang, Qiuping, Xu, Jianzhen, Xu, Yong, Xue, Xiaoqian, Yang, Joy C, Zhang, Yan, Zou, June X   +17 more
core   +2 more sources

Short‐chain acyl post‐translational modifications in cancers: Mechanisms, roles, and therapeutic implications

Cancer Communications, Volume 45, Issue 10, Page 1247-1284, October 2025.
Abstract Post‐translational modifications (PTMs) play a pivotal role in epigenetic regulation and are key pathways for modulating protein functionality. PTMs involve the covalent attachment of distinct chemical groups, such as succinyl, crotonyl, and lactyl, at specific protein sites, which alter protein structure, function, stability, and activity ...
Ting Wu, Yingqi Zhao, Xin Zhang, Yuanhe Wang, Qiuchen Chen, Mingrong Zhang, Huan Sheng, Yuying Zhang, Jinyu Guo, Jun Li, Yuxuan Fan, Ziqing Wang, Yalun Li, Haoran Wang, Minjie Wei, Xiaoyun Hu, Huizhe Wu   +16 more
wiley   +1 more source

Transcriptional repression of Hox genes by C. elegans HP1/HPL and H1/HIS-24.

, 2012
Elucidation of the biological role of linker histone (H1) and heterochromatin protein 1 (HP1) in mammals has been difficult owing to the existence of a least 11 distinct H1 and three HP1 subtypes in mice.
Jedrusik-Bode, M., Opitz, L., Salinas-Riester, G., Studencka, M., Wesolowski, R., Wisniewski, J.   +5 more
core   +1 more source

Epigenomes in Cardiovascular Disease. [PDF]

, 2018
If unifying principles could be revealed for how the same genome encodes different eukaryotic cells and for how genetic variability and environmental input are integrated to impact cardiovascular health, grand challenges in basic cell biology and ...
McKinsey TA, Morimoto T, Poller W, Turner BM, Wang Y   +4 more
core   +1 more source

Assessing Cytochrome P450 Drug Interaction Risk for Dordaviprone Using Physiologically Based Pharmacokinetic Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 10, Page 1695-1704, October 2025.
ABSTRACT A physiologically based pharmacokinetic (PBPK) model was developed and verified for dordaviprone, a small molecule with antitumor effects in glioma patients. The model was applied to assess the drug–drug interaction (DDI) potential of dordaviprone as a victim of CYP3A4 inhibitors and inducers, and as a perpetrator of CYP3A4, CYP2C8, CYP2D6 ...
Swati Jaiswal, Nikunjkumar K. Patel, Hannah M. Jones, Savannah McFeely, Shamia L. Faison, Tim Tippin, Odin Naderer   +6 more
wiley   +1 more source

Neuroradiological, genetic and clinical characteristics of histone H3 K27-mutant diffuse midline gliomas in the Kansai Molecular Diagnosis Network for CNS Tumors (Kansai Network): multicenter retrospective cohort

Acta Neuropathologica Communications
This study aims to elucidate the clinical and molecular characteristics, treatment outcomes and prognostic factors of patients with histone H3 K27-mutant diffuse midline glioma.
Nobuhide Hayashi, Junya Fukai, Hirokazu Nakatogawa, Hiroshi Kawaji, Ema Yoshioka, Yoshinori Kodama, Kosuke Nakajo, Takehiro Uda, Kentaro Naito, Noriyuki Kijima, Yoshiko Okita, Naoki Kagawa, Yoshinobu Takahashi, Naoya Hashimoto, Hideyuki Arita, Koji Takano, Daisuke Sakamoto, Tomoko Iida, Yoshiki Arakawa, Takeshi Kawauchi, Yukihiko Sonoda, Yuta Mitobe, Kenichi Ishibashi, Masahide Matsuda, Takamune Achiha, Takahiro Tomita, Masahiro Nonaka, Keijiro Hara, Noriyoshi Takebe, Takashi Tsuzuki, Yoshikazu Nakajima, Shiro Ohue, Nobuyuki Nakajima, Akira Watanabe, Akihiro Inoue, Masao Umegaki, Daisuke Kanematsu, Asako Katsuma, Miho Sumida, Tomoko Shofuda, Masayuki Mano, Manabu Kinoshita, Kanji Mori, Naoyuki Nakao, Yonehiro Kanemura   +44 more
doaj   +1 more source

Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes. [PDF]

, 2018
Epigenetics contributes to the pathogenesis of immune-mediated diseases like rheumatoid arthritis (RA). Here we show the first comprehensive epigenomic characterization of RA fibroblast-like synoviocytes (FLS), including histone modifications (H3K27ac ...
Ai, Rizi, Ainsworth, Richard I, Bachman, Kurtis E, Bai, Yuchen, Boyle, David L, Ding, Bo, Firestein, Gary S, Gulko, Percio S, Hammaker, Deepa, Krishna, Vinod, Laragione, Teresina, Maeshima, Keisuke, Nagpal, Sunil, Palescandolo, Emanuele, Pocalyko, David, Wang, Mengchi, Wang, Wei, Whitaker, John W, Wildberg, Andre   +18 more
core   +2 more sources