Ascorbic Acid Prevents Loss of Dlk1-Dio3 Imprinting and Facilitates Generation of All-iPS Cell Mice from Terminally Differentiated B Cells [PDF]
, 2012 The generation of induced pluripotent stem cells (iPSCs) often results in aberrant epigenetic silencing of the imprinted Dlk1-Dio3 gene cluster, compromising the ability to generate entirely iPSC-derived adult mice ('all-iPSC mice').
Apostolou, Effie +11 more
core +1 more source
Epigenetic treatment of solid tumours. A review of clinical trials [PDF]
, 2015 Epigenetic treatment has been approved by regulatory agencies for haematological malignancies. The success observe in cutaneous lymphomas represents a proof of principle that similar results may be obtained in solid tumours. Several agents that interfere
CODACCI PISANELLI, Giovanni +2 more
core +2 more sources
Therapeutic targeting using tumor specific peptides inhibits long non-coding RNA HOTAIR activity in ovarian and breast cancer [PDF]
, 2017 Long non-coding RNAs (lncRNAs) play key roles in human diseases, including cancer. Functional studies of the lncRNA HOTAIR (HOX transcript antisense RNA) provide compelling evidence for therapeutic targeting of HOTAIR in cancer, but targeting lncRNAs in ...
Fang, Fang +5 more
core +1 more source
Childhood maltreatment and adult psychopathology: pathways to hypothalamic-pituitary-adrenal axis dysfunction [PDF]
, 2009 OBJECTIVE: The aim of this paper was to examine the relationship between childhood maltreatment and adult psychopathology, as reflected in hypothalamic-pituitary-adrenal axis dysfunction.
Carpenter, Linda L. +5 more
core +2 more sources
H3.1K27M-induced misregulation of the TONSOKU-H3.1 pathway causes genomic instability
Nature CommunicationsThe oncomutation lysine 27-to-methionine in histone H3 (H3K27M) is frequently identified in tumors of patients with diffuse midline glioma-H3K27 altered (DMG-H3K27a).
Wenxin Yuan +10 more
doaj +1 more source
Neuro-OncologyAbstract BACKGROUND Pediatric diffuse midline gliomas (DMGs), H3 K27-altered, represent the 5-10% of all pediatric brain tumors. The preferential location is the brainstem (diffuse intrinsic pontine glioma, DIPG). Median overall survival is 11 months.
Cacchione, A +11 more
openaire +2 more sources
DDEL-19. DRUG-TUMOR RESIDENCE TIME DRIVES EFFICACY OF CONVECTION-ENHANCED DELIVERY IN H3 K27-ALTERED DIFFUSE MIDLINE GLIOMA [PDF]
Neuro OncolAbstract Advancements in understanding H3 K27-altered diffuse midline glioma (DMG) biology have not yet translated into effective therapies for these tumors likely due to delivery challenges across the blood-brain barrier (BBB) and variable tumor genetics.
Julian S Rechberger +4 more
europepmc +2 more sources
Patient with Diffuse Midline Glioma, H3 K27-altered, Carrying an FGFR1 Mutation Who Experienced Thalamic Hemorrhage: A Case Report and Literature Review. [PDF]
NMC Case Rep J, 2023 Matsunaga K +4 more
europepmc +1 more source
Feasibility of probe washing after stereotactic needle biopsy as a novel technique for developing cell lines and xenografts of H3 K27-altered diffuse midline gliomas. [PDF]
J Neurosurg Pediatr, 2023 Rechberger JS +5 more
europepmc +1 more source