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Characteristics and outcomes of diffuse non-midline gliomas with H3F3A gene mutation in the Kansai Molecular Diagnosis Network for CNS Tumors (Kansai Network): multicenter retrospective cohort study. [PDF]

Acta Neuropathol Commun
Nakatogawa H, Fukai J, Kawaji H, Hayashi N, Yoshioka E, Kodama Y, Nakajo K, Uda T, Arakawa Y, Takada S, Kijima N, Ishibashi K, Okuda T, Sonoda Y, Ohue S, Arita H, Matsuda M, Fukami T, Tomita T, Inoue A, Achiha T, Kashiwagi H, Kanematsu D, Katsuma A, Sumida M, Shofuda T, Mano M, Kinoshita M, Mori K, Inenaga C, Kanemura Y.   +30 more
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H3 K27-altered diffuse midline glioma presenting as massive cerebellopontine hemorrhage

Child's Nervous System, 2023
We report the case of a 14-year-old boy who presented with extensive cerebellar and brainstem hemorrhage. Our presumptive diagnosis was a ruptured arteriovenous malformation (AVM), but two cerebral angiograms showed no significant vascular abnormalities.
Tej D, Azad, Anita L, Kalluri, Landon J, Hansen, Adam, Ammar, Alan R, Cohen   +4 more
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Adult diffuse midline gliomas H3 K27-altered: review of a redefined entity

Journal of Neuro-Oncology, 2022
Diffuse midline glioma (DMG) H3 K27-altered is a type of high-grade gliomas first recognized as a new entity in the 2016 World Health Organization Classification of Central Nervous System (CNS) Tumors as DMG H3 K27M-mutant, recently renamed in the new 2021 WHO classification.
Carlos Axel López-Pérez, Xochitl Franco-Mojica, Ricardo Villanueva-Gaona, Alexandra Díaz-Alba, Marco Antonio Rodríguez-Florido, Victor Garcia Navarro   +5 more
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Distinct MRI characteristics of spinal cord diffuse midline glioma, H3 K27-altered in comparison to spinal cord glioma without H3 K27-alteration and demyelination disorder

Acta Radiologica, 2023
Background An applicable magnetic resonance imaging (MRI) biomarker for diffuse midline glioma (DMG), H3 K27-altered of the spinal cord is important for non-invasive diagnosis. Purpose To evaluate the efficacy of conventional MRI (cMRI) in distinguishing between DMGs, H3 K27-altered, gliomas without H3 K27-alteration, and demyelinating lesions in the ...
Yinwei Ying, Xiujuan Liu, Xuanxuan Li, Nan Mei, Zhuoying Ruan, Yiping Lu, Bo Yin   +6 more
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Tumor progression of diffuse median glioma with H3 K27 alteration from pilocytic astrocytoma to glioblastoma

Arkhiv patologii, 2022
In the latest revisions of the WHO Classification of CNS Tumors, carried out in 2016 and 2021, the traditional histogenetic classification of gliomas is rebuilt on a new molecular genetic basis, according to which diffuse midline glioma with alteration of histone H3 K27 is distinguished as a specific pediatric oncosyndrome.
Yu.M. Zabrodskaya, V.S. Sidorin, M.S. Nikolaenko, K.A. Samochernikh   +3 more
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Abstract 2052: High-plex spatial multiomics of pediatric and adult diffuse midline glioma, H3 K27-altered

Cancer Research, 2023
Abstract Background: Diffuse midline glioma (DMG), H3 K27-altered are highly aggressive malignancies of the central nervous system that affect both pediatric and adult populations. The immune layout and genetic changes within the tumor microenvironment associated with these high-grade malignancies are thought to play an integral role in ...
Sudarshawn Damodharan, Alyssa Rosenbloom, Mahua Dey   +2 more
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Genetic alteration analysis of non-pediatric diffuse midline glioma, H3 K27-altered

Human Pathology
Diffuse midline gliomas with H3 K27-alteration (DMGH3) are lethal and inoperable brain tumors. Although DMGH3s mainly occur in pediatric patients, they have also occurred in adult patients. This study aimed to analyze the clinicopathological significance of targetable genetic alterations in non-pediatric DMGH3.
Hanbin Jang, Seyoung Moon, Hyun Jung Kwon, Sejoon Lee, Gheeyoung Choe, Kyu Sang Lee   +5 more
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266 Combination Drug Therapy in H3 K27-Altered Diffuse Midline Glioma Enhances Tumor Retention and Treatment Efficacy

Neurosurgery
INTRODUCTION: Diffuse midline gliomas (DMG) with H3 K27 alterations are uniformly lethal tumors for which no therapy has been found to be effective. One reason for our therapy failure is the blood-brain barrier (BBB), which severely restricts uptake and accumulation of systemically administered drugs in the brain.
Julian Rechberger, Jacob Anderson, Jizhi Ge, Liang Zhang, David J. Daniels   +4 more
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