Results 141 to 149 of about 5,620 (149)

A comprehensive multicenter analysis of clinical, molecular, and imaging characteristics and outcomes of H3 K27–altered diffuse midline glioma in adults

Journal of Neurosurgery
OBJECTIVE The objective was to comprehensively investigate the clinical, molecular, and imaging characteristics and outcomes of H3 K27–altered diffuse midline glioma (DMG) in adults. METHODS Retrospective chart and imaging reviews were performed in 111 adult patients with H3 K27–altered DMG from two tertiary institutions.
Yongsik, Sim, Andrew C, McClelland, Kaeum, Choi, Kyunghwa, Han, Yae Won, Park, Sung Soo, Ahn, Jong Hee, Chang, Se Hoon, Kim, Sharon, Gardner, Seung-Koo, Lee, Rajan, Jain   +10 more
openaire   +2 more sources

Identification of prognostic imaging biomarkers in H3 K27-altered diffuse midline gliomas in adults: impact of tumor oxygenation imaging biomarkers on survival

Neuroradiology
To investigate prognostic markers for H3 K27-altered diffuse midline gliomas (DMGs) in adults with clinical, qualitative and quantitative imaging phenotypes, including tumor oxygenation characteristics.Retrospective chart and imaging reviews were conducted on 32 adults with H3 K27-altered DMGs between 2017 and 2023.
Yongsik Sim, Kaeum Choi, Kyunghwa Han, Seo Hee Choi, Narae Lee, Yae Won Park, Na-Young Shin, Sung Soo Ahn, Jong Hee Chang, Se Hoon Kim, Seung-Koo Lee   +10 more
openaire   +2 more sources

CSIG-03. H3 K27-ALTERED GLIOMA STEM CELLS OVEREXPRESSING DKK1 ENHANCES BLOOD-TUMOR BARRIER PERMEABILITY AND XENOGRAFT MODEL SURVIVAL

Neuro-Oncology
Abstract The blood–tumor barrier (BTB) among malignant glioma selectively hinders therapy exposure and distribution. The Wnt/β-catenin signaling pathway ensures high BTB integrity and promotes glioma stemness. We hypothesize that transduction of H3 K27-altered glioma stem cells with overexpressing Wnt/β-catenin inhibitors will enhance
Sadhana Jackson, Sanghee Lim, Minhye Kwak, Kayen Tang   +3 more
openaire   +1 more source

Identification of Prognostic Imaging Biomarkers in H3 K27-Altered Diffuse Midline Gliomas in Adults: Impact of Tumor Oxygenation Biomarkers

ISMRM Annual Meeting
Motivation: The prognostic markers of H3 K27-altered diffuse midline gliomas (DMGs) in adults have yet to be studied. Goal(s): To investigate prognostic markers for H3 K27-altered DMGs in adults, including clinical, qualitative, quantitative imaging phenotypes, and tumor oxygenation characteristics.
Yongsik Sim, Yae Won Park, Sung Soo Ahn, Seung-Koo Lee   +3 more
openaire   +1 more source

EXTH-43. Ara-C suppresses H3 K27-altered spinal cord diffuse midline glioma growth and enhances immune checkpoint blockade sensitivity

Neuro-Oncology
Abstract H3 K27-altered spinal cord diffuse midline glioma (H3-SCDMG) represents a challenging malignancy with limited treatment options and experiment models. This study aimed to investigate novel therapeutic strategies for H3-SCDMG by leveraging the tumor’s biological characteristics and newly established experiment models ...
Ruichao Chai, Bo Pang, Yilin Wu, Tao Jiang, Yongzhi Wang   +4 more
openaire   +1 more source

Video of the segmented tumor in a 14-year-old girl with DMG, H3 K27-altered.

ASVIDE, 2022
Baolian Zhao, Ke Sun, Zhengwei Zhang, Tao Xu, Liang Zhao, Chen Liu, Yi Xiao   +6 more
openaire   +1 more source

Incidental Diffuse Midline Glioma, H3 K27-Altered of the Pons Without Significant Coalterations

JCO Precision Oncology
Kee Kiat Yeo, Phoebe Power, Hart Lidov, Tom Rosenberg, Katherine E. Warren, Edward R. Smith, Daphne Haas-Kogan, Pratiti Bandopadhayay   +7 more
openaire   +1 more source

Clinical and survival differences between thalamic glioblastoma and thalamic diffuse midline glioma, H3 K27-altered

Journal of Neuro-Oncology
Peigang Ji, Chen Li, Yuan Wang, Shaochun Guo, Yulong Zhai, Na Wang, Jinghui Liu, Liang Wang   +7 more
openaire   +1 more source

Histopathological grades as prognostic factors of H3 K27-altered diffuse midline glioma and their prediction using multiparametric MR imaging

Neuroradiology
Yujiao Deng, Xiaorui Su, Yuan Yang, Jing Gong, Ni Chen, Qiang Yue   +5 more
openaire   +1 more source