Results 21 to 30 of about 5,620 (149)

Pediatric spinal cord diffuse midline glioma, H3 K27-altered with intracranial and spinal leptomeningeal spread: A case report. [PDF]

Neuroradiol J, 2022
Primary spinal cord high-grade gliomas, including those histologically identified as glioblastoma (GBM), are a rare entity in the pediatric population but should be considered in the differential diagnosis of intramedullary lesions. Pediatric spinal cord high-grade gliomas have an aggressive course with poor prognosis.
Serrallach BL, Tran BH, Bauer DF, Mohila CA, Adesina AM, McGovern SL, Lindsay HB, Huisman TA.   +7 more
europepmc   +3 more sources

Pathological Classification of the Intramedullary Spinal Cord Tumors According to 2021 World Health Organization Classification of Central Nervous System Tumors, a Single-Institute Experience [PDF]

Neurospine, 2022
According to the new 2021 World Health Organization (WHO) classification of tumors of the central nervous system (CNS) the classification of the primary intramedullary spinal cord tumors (IM-SCT) follows that of CNS tumors.
Sung-Hye Park, Jae Kyung Won, Chi Heon Kim, Ji Hoon Phi, Seung-Ki Kim, Seung Hong Choi, Chun Kee Chung   +6 more
doaj   +1 more source

INNV-13. INDOLENT H3 K27-ALTERED DIFFUSE MIDLINE GLIOMA [PDF]

Neuro Oncol, 2022
Abstract INTRODUCTION H3 K27-altered diffuse midline glioma (DMG) is an aggressive central nervous system tumor that is universally fatal with a median survival of 8-12 months after diagnosis. Here we present a patient who was incidentally found to have a lesion within the right thalamus on brain ...
Sudarshawn Damodharan, Jeffrey Helgager, Diane Puccetti   +2 more
europepmc   +2 more sources

Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes [PDF]

, 2020
Chromatin states must be maintained during cell proliferation to uphold cellular identity and genome integrity. Inheritance of histone modifications is central in this process. However, the histone modification landscape is challenged by incorporation of
Alabert, Allshire, Berry, Blackledge, Blasi, Coleman, Cooper, Ernst, Ferrari, Fröhlich, Hass, Healy, Hindmarsh, Hojfeldt, Huang, Højfeldt, Jani, Jasencakova, Jung, Justin, King, Langmead, Laprell, Laugesen, Lee, Loos, Loyola, Lu, MacLean, Maier, Margueron, Marks, McCabe, Mohammad, Noberini, Oksuz, Petryk, Poepsel, Reinberg, Reveron-Gomez, Sanulli, Scharf, Schmitges, Schuettengruber, Schwarz, Stafford, Stapor, Streubel, Tatton-Brown, van Mierlo, Voigt, Wasserman, Xu, Xu, Yu, Yu, Yuan, Zang, Zheng   +58 more
core   +3 more sources

Histone H3 K27 alterations in central nervous system tumours: Challenges and alternative diagnostic approaches

Molecular and Cellular Probes, 2022
Upon the discovery of frequent oncogenic histone alterations in paediatric diffuse high-grade gliomas, the epigenetic and transcriptional landscapes of tumours have become increasingly important aspects of diagnostic and prognostic analysis. The replacement of lysine 27 with methionine in H3 histone variants - H3 p.K28M (K27M) - was the first reported ...
Nour Kurdi, Attila Mokanszki, Gabor Mehes, Judit Bedekovics   +3 more
openaire   +2 more sources

Comprehensive profiling of stem-like features in pediatric glioma cell cultures and their relation to the subventricular zone

Acta Neuropathologica Communications, 2023
Pediatric high-grade gliomas (pHGG) are brain tumors occurring in children and adolescents associated with a dismal prognosis despite existing treatments. Therapeutic failure in both adult and pHGG has been partially imputed to glioma stem cells (GSC), a
Marc-Antoine Da-Veiga, Natacha Coppieters, Arnaud Lombard, Bernard Rogister, Virginie Neirinckx, Caroline Piette   +5 more
doaj   +1 more source

Imaging diagnosis and treatment selection for brain tumors in the era of molecular therapeutics

Cancer Imaging, 2022
Currently, most CNS tumors require tissue sampling to discern their molecular/genomic landscape. However, growing research has shown the powerful role imaging can play in non-invasively and accurately detecting the molecular signature of these tumors ...
Saivenkat Vagvala, Jeffrey P. Guenette, Camilo Jaimes, Raymond Y. Huang   +3 more
doaj   +1 more source

Automated Determination of the H3 K27-Altered Status in Spinal Cord Diffuse Midline Glioma by Radiomics Based on T2-Weighted MR Images. [PDF]

AJNR Am J Neuroradiol, 2023
Conventional MR imaging is not sufficient to discern the H3 K27-altered status of spinal cord diffuse midline glioma. This study aimed to develop a radiomics-based model based on preoperative T2WI to determine the H3 K27-altered status of spinal cord diffuse midline glioma.Ninety-seven patients with confirmed spinal cord diffuse midline gliomas were ...
Li J, Wang Y, Weng J, Qu L, Wu M, Guo M, Sun J, Hu G, Gong X, Liu X, Duan Y, Zhuo Z, Jia W, Liu Y.   +13 more
europepmc   +3 more sources

A rare presentation of primary lateral ventricle H3 K27-altered diffuse midline glioma in a 14-year-old girl: a case description. [PDF]

Quant Imaging Med Surg, 2022
Zhao B, Sun K, Zhang Z, Xu T, Zhao L, Liu C, Xiao Y.   +6 more
europepmc   +3 more sources

Molecular Characterization and Treatment Approaches for Pediatric H3 K27-Altered Diffuse Midline Glioma: Integrated Systematic Review of Individual Clinical Trial Participant Data. [PDF]

Cancers (Basel), 2023
Diffuse midline glioma (DMG), H3 K27-altered are highly aggressive, incurable central nervous system (CNS) tumors. The current standard palliative treatment is radiotherapy, with most children succumbing to the disease in less than one year from the time of diagnosis.
Damodharan S, Abbott A, Kellar K, Zhao Q, Dey M.   +4 more
europepmc   +3 more sources