Results 31 to 40 of about 5,620 (149)

Spotlights on adult patients with pediatric-type diffuse gliomas in accordance with the 2021 WHO classification of CNS tumors

Frontiers in Neuroscience, 2023
IntroductionThe fifth edition of the World Health Organization (WHO) classification of central nervous system (CNS) tumors released in 2021 formally defines pediatric-type diffuse gliomas.
Wenlin Chen, Shanmu Jin, Shanmu Jin, Qianshu Liu, Qianshu Liu, Hai Wang, Yu Xia, Yu Xia, Xiaopeng Guo, Xiaopeng Guo, Siying Guo, Siying Guo, Yaning Wang, Yixin Shi, Yixin Shi, Delin Liu, Delin Liu, Yilin Li, Yilin Li, Yuekun Wang, Hao Xing, Junlin Li, Junlin Li, Jiaming Wu, Jiaming Wu, Tingyu Liang, Tian Qu, Tian Qu, Huanzhang Li, Huanzhang Li, Tianrui Yang, Tianrui Yang, Kun Zhang, Kun Zhang, Yu Wang, Yu Wang, Wenbin Ma, Wenbin Ma   +37 more
doaj   +1 more source

Fulminant hemorrhagic course of a thalamic H3 K27-altered diffuse midline glioma in an adult patient: illustrative case. [PDF]

J Neurosurg Case Lessons
BACKGROUND H3 K27-altered diffuse midline gliomas (DMGs) are rare tumors, which are, regardless of their histological appearance, classified as World Health Organization grade 4 tumors. They are characterized by a diffuse growth pattern, midline anatomical location, and poor prognosis.
Poletti N, Marques LL, Deigendesch N, Soleman J, Mariani L, Guzman R, Rychen J.   +6 more
europepmc   +3 more sources

VRK3 depletion induces cell cycle arrest and metabolic reprogramming of pontine diffuse midline glioma - H3K27 altered cells

Frontiers in Oncology, 2023
We previously identified VRK3 as a specific vulnerability in DMG-H3K27M cells in a synthetic lethality screen targeting the whole kinome. The aim of the present study was to elucidate the mechanisms by which VRK3 depletion impact DMG-H3K27M cell fitness.
Virginie Menez, Thomas Kergrohen, Tal Shasha, Claudia Silva-Evangelista, Ludivine Le Dret, Lucie Auffret, Chloé Subecz, Manon Lancien, Yassine Ajlil, Irma Segoviano Vilchis, Kévin Beccaria, Kévin Beccaria, Thomas Blauwblomme, Estelle Oberlin, Jacques Grill, Jacques Grill, David Castel, Marie-Anne Debily, Marie-Anne Debily   +18 more
doaj   +1 more source

Genomic Profiling of Pediatric Solid Tumors With a Dual DNA/RNA Panel: JCCG-TOP2 Study. [PDF]

Cancer Sci
In the JCCG‐TOP2 nationwide pediatric cancer genomic profiling study, 204 patients' tumors and peripheral blood from 50 institutions across Japan were successfully analyzed using a dual DNA/RNA panel. A total of 147 (72%) had potentially actionable findings, including diagnostic, prognostic, and therapeutic findings in 111 (54%), 61 (30%), and 64 (31%),
Tao K, Yoshioka T, Kato M, Komatsu K, Tsujimoto S, Sakamoto K, Tanimura K, Sugiyama M, Sekiguchi M, Nakano Y, Otani Y, Yatabe Y, Yoshida A, Okita H, Hirato J, Kohashi K, Tanaka Y, Kohsaka S, Kubo T, Sunami K, Hirata M, Tsutsumi S, Aburatani H, Koh K, Hirayama M, Karakawa S, Terashita Y, Fujisaki H, Yagi T, Yoneda A, Mochizuki S, Shichino H, Suzuki T, Takimoto T, Ichimura K, Ogawa C, Matsumoto K, Ichikawa H, Kato M.   +38 more
europepmc   +2 more sources

Emerging roles of telomeric chromatin alterations in cancer [PDF]

, 2019
Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the ...
Biroccio, Annamaria, Cacchione, Stefano, Rizzo, Angela   +2 more
core   +1 more source

Local Effect of Enhancer of Zeste-Like Reveals Cooperation of Epigenetic and cis-Acting Determinants for Zygotic Genome Rearrangements [PDF]

, 2014
International audienceIn the ciliate Paramecium tetraurelia, differentiation of the somatic nucleus from the zygotic nucleus is characterized by massive and reproducible deletion of transposable elements and of 45,000 short, dispersed, single-copy ...
Denby Wilkes, Cyril, Duharcourt, Sandra, Frapporti, Andrea, Lhuillier-Akakpo, Maoussi, Matelot, Mélody, Sperling, Linda, Vervoort, Michel   +6 more
core   +11 more sources

ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing. [PDF]

, 2009
Constitutive heterochromatin in Arabidopsis thaliana is marked by repressive chromatin modifications, including DNA methylation, histone H3 dimethylation at Lys9 (H3K9me2) and monomethylation at Lys27 (H3K27me1).
Bernatavichute, Yana V, Cokus, Shawn, Feng, Suhua, Jacob, Yannick, Jacobsen, Steven E, Johnson, Lianna M, LeBlanc, Chantal A, Michaels, Scott D, Pellegrini, Matteo, Stroud, Hume   +9 more
core   +1 more source

The promise of metabolic imaging in diffuse midline glioma

Neoplasia: An International Journal for Oncology Research, 2023
Recent insights into histopathological and molecular subgroups of glioma have revolutionized the field of neuro-oncology by refining diagnostic categories. An emblematic example in pediatric neuro-oncology is the newly defined diffuse midline glioma (DMG)
Samantha Lovibond, Alexandra N. Gewirtz, Luca Pasquini, Simone Krebs, Maya S. Graham   +4 more
doaj   +1 more source

Biophysical characterization of histone H3.3 K27M point mutation [PDF]

, 2018
K
Boros-Oláh, Beáta, Hetey, Szabolcs, Karányi, Zsolt, Kuik-Rózsa, Tímea, Li, Qiuzhen, Roszik, Jason, Szabó, Zoltán, Szalóki, Nikoletta, Székvölgyi, Lóránt, Tóth, Katalin Ágnes, Vámosi, György   +10 more
core   +1 more source

Histone H3 methylation orchestrates transcriptional program in mouse spermatogenic cell line

The Journal of Reproduction and Development, 2020
Changes in histone modifications always correlate with altered transcriptional activities of genes. Recent studies have shown that the mutation of certain lysine residues to methionine in the histone variant H3.3 can act as a valuable tool to reduce ...
Xiao-fei WANG, Qing TIAN, Wei-bing QIN, Ying YIN, Ling ZENG, Yun-ge TANG, Ping SU, Li-quan ZHOU   +7 more
doaj   +1 more source