High affinity binding of H3K14ac through collaboration of bromodomains 2, 4 and 5 is critical for the molecular and tumor suppressor functions of PBRM1. [PDF]
, 2018 Polybromo-1 (PBRM1) is an important tumor suppressor in kidney cancer. It contains six tandem bromodomains (BDs), which are specialized structures that recognize acetyl-lysine residues.
Alicea-Velázquez, Nilda L. +10 more
core +2 more sources
Quantitating the specificity and selectivity of Gcn5-mediated acetylation of histone H3. [PDF]
PLoS ONE, 2013 Lysine acetyltransferases (KATs) play a unique role in regulating gene transcription as well as maintaining the epigenetic state of the cell. KATs such as Gcn5 and p300/CBP can modify multiple residues on a single histone; however, order and specificity ...
Yin-Ming Kuo, Andrew J Andrews
doaj +1 more source
Chinese Journal of Contemporary Neurology and Neurosurgery, 2022 Objective Histological morphology, immunophenotype and molecular diagnosis of gliomas were reported and classified according to fifth edition of the 2021 World Health Organization (WHO) Classification of Tumors of the Central Nervous System (WHO CNS5 ...
JIA Xiao⁃kun +4 more
doaj +1 more source
cIMPACT-NOW update 11: Proposal on adaptation of diagnostic criteria for IDH- and H3-wildtype diffuse high-grade gliomas and for posterior fossa ependymal tumors. [PDF]
Brain PatholAbstract The Consortium to Inform Molecular and Practical Approaches to Central Nervous System Tumor Taxonomy (cIMPACT‐NOW) updates provide guidelines for the diagnosis of central nervous system (CNS) tumors and suggestions for future World Health Organization (WHO) classification.
Wesseling P +16 more
europepmc +2 more sources
Metabotropic glutamate 2/3 receptors and epigenetic modifications in psychotic disorders: a review [PDF]
, 2016 Schizophrenia and Bipolar Disorder are chronic psychiatric disorders, both considered as "major psychosis"; they are thought to share some pathogenetic factors involving a dysfunctional gene x environment interaction.
Grayson, Danis R +4 more
core +2 more sources
Neurogenic to Gliogenic Fate Transition Perturbed by Loss of HMGB2 [PDF]
, 2017 Mouse cortical development relies heavily on a delicate balance between neurogenesis and gliogenesis. The lateral ventricular zone produces different classes of excitatory pyramidal cells until just before birth, when the production of astroglia begins ...
Abraham, A. B. +3 more
core +1 more source
Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc. [PDF]
PLoS ONE, 2009 BACKGROUND:The Myc oncoprotein, a transcriptional regulator involved in the etiology of many different tumor types, has been demonstrated to play an important role in the functions of embryonic stem (ES) cells.
Chin-Hsing Lin +4 more
doaj +1 more source
Therapeutic Targeting of Histone Modifications in Adult and Pediatric High-Grade Glioma [PDF]
, 2017 Recent exciting work partly through The Cancer Genome Atlas has implicated epigenetic mechanisms including histone modifications in the development of both pediatric and adult high-grade glioma (HGG).
Kurian, Kathreena M +4 more
core +1 more source
PLoS Biology, 2020 Identification of target genes that mediate required functions downstream of transcription factors is hampered by the large number of genes whose expression changes when the factor is removed from a specific tissue and the numerous binding sites for the ...
Marie Berenguer +3 more
doaj +1 more source
ITIH5 mediates epigenetic reprogramming of breast cancer cells [PDF]
, 2017 Extracellular matrix (ECM) is known to maintain epithelial integrity. In carcinogenesis ECM degradation triggers metastasis by controlling migration and differentiation including cancer stem cell (CSC) characteristics.
Aljona Gaiko-Shcherbak +19 more
core +6 more sources