Gene regulation and epigenotype in Friedreich's ataxia [PDF]
, 2008 Friedreich??????s ataxia (FRDA) is known to be provoked by an abnormal GAA-repeat expansion located in the first intron of the FXN gene. As a result of the GAA expansion, patients exhibit low levels of FXN mRNA, leading to FRDA.
Rothe, Nadine, Rothe, Nadine
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Histone posttranslational modifications and cell fate determination: Lens induction requires the lysine acetyltransferases CBP and p300 [PDF]
, 2013 Lens induction is a classical embryologic model to study cell fate determination. It has been proposed earlier that specific changes in core histone modifications accompany the process of cell fate specification and determination.
Ashery-Padan, Ruth +14 more
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Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells [PDF]
, 2006 The POU domain transcription factor OCT4 is a key regulator of pluripotency in the early mammalian embryo and is highly expressed in the inner cell mass of the blastocyst. Consistent with its essential role in maintaining pluripotency, Oct4 expression is
Adjaye, J. +8 more
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The histone chaperone Vps75 forms multiple oligomeric assemblies capable of mediating exchange between histone H3–H4 tetramers and Asf1–H3–H4 complexes [PDF]
, 2016 Wellcome Trust [094090, 097945, 099149]; Medical Research Council [G1100021]. Funding for open access charge: Wellcome Trust.Vps75 is a histone chaperone that has been historically characterized as homodimer by X-ray crystallography.
Angus Lamond +11 more
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Advanced Science, EarlyView.Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen +8 more
wiley +1 more source
The H3 K27-altered, Extent of Resection and Survival in Pediatric High-grade Spinal Cord Gliomas
, 2022 Abstract Purpose Pediatric high-grade spinal cord gliomas (pHGSG) are classified into two prognostically meaningful subtypes. The purpose of our study is to describe clinical characteristics and management of two pHGSG subtypes, especially focus on the effect of surgical resection in these two subtypes.
Qi-Shuai Yu +3 more
openaire +1 more source
NCOG-35. IDENTIFYING PROGNOSTIC FACTORS IN PEDIATRIC DIFFUSE MIDLINE GLIOMAS, H3 K27-ALTERED [PDF]
Neuro OncolAbstract INTRODUCTION Diffuse midline gliomas, H3 K27-altered (DMG) are rare, grade 4 tumors localized to the diencephalon, brainstem, and cervical spine. DMGs, characterized by a K27M missense mutation in histone H3, often cannot be safely resected and predominantly present with poor outcomes in ...
Yufan Yang +6 more
europepmc +2 more sources
Chemical Ubiquitination for Decrypting a Cellular Code [PDF]
, 2016 The modification of proteins with ubiquitin (Ub) is an important regulator of eukaryotic biology and deleterious perturbation of this process is widely linked to the onset of various diseases. The regulatory capacity of the Ub signal is high and, in part,
Abeywardana +177 more
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Advanced Science, EarlyView.Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu +20 more
wiley +1 more source
Epigenetic regulators as promising therapeutic targets in acute myeloid leukemia. [PDF]
, 2015 Acute myeloid leukemia (AML), the most prevalent acute leukemia in adults, is an aggressive hematological malignancy arising in hematopoietic stem and progenitor cells.
Gallipoli, Paolo +2 more
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